Dexamethasone Sodium Phosphate Loaded Modified Cyclodextrin Based Nanoparticles: An Efficient Treatment for Rheumatoid Arthritis

Jadhav, Dhananjay; Vavia, Pradeep R.

doi:10.1016/j.xphs.2020.10.023

Cited by 20 publications

(9 citation statements)

References 54 publications

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“…Other Contributory factors include decreased food intake, hyperalgesia, allodynia, distress, decreased metabolism of lipids and proteins, muscle proteolysis and decreased intestinal absorption. The use of nanoparticles significantly restored the weight to normal owing to reduced inflammation as revealed in previous studies (Jadhav & Vavia 2020).…”

Section: Discussionsupporting

confidence: 71%

“…The arthritic score was significantly raised in experimental arthritic rats. After therapeutic use of nanoparticles, the arthritic score significantly decreased as the inflammatory signs showed a significant reduction due to decreased release of inflammatory mediators like TNFα as evidenced in the results of previous studies (Jadhav & Vavia 2020).…”

Section: Discussionsupporting

confidence: 55%

“…The therapeutic use of nanoparticles restored the paw measurement of arthritic rats owing to reduced inflammatory signs i.e. edematous swelling as evidenced from results of previous studies (Jadhav & Vavia 2020).…”

Section: Discussionmentioning

confidence: 58%

“…Blood was centrifuged for 10minutes at 10,000 rpm and serum was separated and stored in a refrigerator at 4°C. EDTA tubes were used to collect blood samples of rats for hematological analysis (Jadhav & Vavia 2020).…”

Section: Blood Samples Collectionmentioning

confidence: 99%

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2021

Pak. J. Pharm. Sci

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Rheumatoid arthritis is an inflammatory arthropathy, autoimmune in nature, leading to disability of joints involving structural destruction of articular bone and cartilage due to inflammation in synovium resulting in joint stiffness, swelling and pain. Nanomedicine has played a crucial role in improving the efficacy of treatment by controlling the release of pharmacologically active ingredients to increase bioavailability and achieve uniform and targeted delivery of drug. In this study, we prepared celecoxib, gingerol and oleanic acid loaded PLGA nanoparticles by solvent evaporation method and nanoparticles were characterized by particle size, zeta potential, polydispersity index, entrapement efficiency and FTIR. FCA is induced in right hand paw of rats for induction of arthritis. Celecoxib, gingerol and oleanic acid loaded PLGA nanoparticles coated with chitosan were given orally to rats for the evaluation of antiarthritic effect of this nanoformulation in rats. Animals were divided into six groups for 21 days trial. On 21 st day blood samples were collected for evaluation of hematological and lipid profile parameters. The data was subjected to statistical analysis by applying one way ANOVA and tukey test. At the end of study it was concluded that PLGA loaded celecoxib, gingerol and oleanic acid coated with chitosan have excellent effects in minimizing the side effects and increasing the therapeutic efficacy of drugs.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 58%

Section: Blood Samples Collectionmentioning

confidence: 99%

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2021

Pak. J. Pharm. Sci

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“…Besides classical liposomes and IOH-NPs, several other NP formulations have been designed ( Figure 4 ). Poly-δ-decalactone/methoxy-polyethylene glycol-based NPs loaded with triamcinolone were superior to the free drug in a model of RA [ 234 ], and the use of cyclodextrin-based NPs loaded with Dex turned out to be highly efficient in the AIA model combined with reduced side effects [ 235 ]. The use of cyclodextrin improved the stability and concurrent bioavailability [ 236 ], and caused enhanced extravasation at the site of inflammation via the EPR effect [ 235 ].…”

Section: Novel Therapeutic Approachesmentioning

confidence: 99%

The Role of Glucocorticoids in Inflammatory Diseases

Reichardt

Amouret

Muzzi

et al. 2021

Cells

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For more than 70 years, glucocorticoids (GCs) have been a powerful and affordable treatment option for inflammatory diseases. However, their benefits do not come without a cost, since GCs also cause side effects. Therefore, strong efforts are being made to improve their therapeutic index. In this review, we illustrate the mechanisms and target cells of GCs in the pathogenesis and treatment of some of the most frequent inflammatory disorders affecting the central nervous system, the gastrointestinal tract, the lung, and the joints, as well as graft-versus-host disease, which often develops after hematopoietic stem cell transplantation. In addition, an overview is provided of novel approaches aimed at improving GC therapy based on chemical modifications or GC delivery using nanoformulations. GCs remain a topic of highly active scientific research despite being one of the oldest class of drugs in medical use.

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Modulation of CD36‐mediated lipid accumulation and senescence by vitamin E analogs in monocytes and macrophages

et al. 2022

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The CD36/FAT scavenger receptor/fatty acids transporter regulates cellular lipid accumulation important for inflammation, atherosclerosis, lipotoxicity, and initiation of cellular senescence. Here we compared the regulatory effects of the vitamin E analogs alpha‐tocopherol (αT), alpha‐tocopheryl phosphate (αTP), and αTP/βCD (a nanocarrier complex between αTP and β‐cyclodextrin [βCD]) and investigated their regulatory effects on lipid accumulation, phagocytosis, and senescence in THP‐1 monocytes and macrophages. Both, αTP and αTP/βCD inhibited CD36 surface exposition stronger than αT leading to more pronounced CD36‐mediated events such as inhibition of DiI‐labeled oxLDL uptake, phagocytosis of fluorescent Staphylococcus aureus bioparticles, and cell proliferation. When compared to βCD, the complex of αTP/βCD extracted cholesterol from cellular membranes with higher efficiency and was associated with the delivery of αTP to the cells. Interestingly, both, αTP and more so αTP/βCD inhibited lysosomal senescence‐associated beta‐galactosidase (SA‐β‐gal) activity and increased lysosomal pH, suggesting CD36‐mediated uptake into the endo‐lysosomal phagocytic compartment. Accordingly, the observed pH increase was more pronounced with αTP/βCD in macrophages whereas no significant increase occurred with αT, alpha‐tocopheryl acetate (αTA) or βCD. In contrast to αT and αTA, the αTP molecule is di‐anionic at neutral pH, but upon moving into the acidic endo‐lysosomal compartment becomes protonated and thus is acting as a base. Moreover, it is expected to be retained in lysosomes since it still carries one negative charge, similar to lysosomotropic drugs. Thus, treatment with αTP or αTP/βCD and/or inhibition of conversion of αTP to αT as it occurs in aged cells may counteract CD36‐mediated overlapping inflammatory, senescent, and atherosclerotic events.

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Dexamethasone Sodium Phosphate Loaded Modified Cyclodextrin Based Nanoparticles: An Efficient Treatment for Rheumatoid Arthritis

Cited by 20 publications

References 54 publications

Untitled

Untitled

The Role of Glucocorticoids in Inflammatory Diseases

Modulation of CD36‐mediated lipid accumulation and senescence by vitamin E analogs in monocytes and macrophages

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