Dexmedetomidine nebulisation attenuates post-operative sore throat in patients undergoing thyroidectomy: A randomised, double-blind, comparative study with nebulised ketamine

Derlin, Thomas; Chacko, Lini; Raphael, Paul O.

doi:10.4103/ija.ija_406_20

Cited by 16 publications

(20 citation statements)

References 24 publications

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“…However, information about its utility in thyroidectomy is scarce. We found three RCTs [24][25][26] evaluating anesthetic instillation before intubation in patients who underwent thyroidectomy (Table 1). Most of them confirm the advantages of topical administration of medicaments before the intubation to decrease the rate of postoperative sore throat.…”

Section: Intubation Maneuvers To Prevent Sore Throatmentioning

confidence: 99%

Locoregional strategies to decrease postoperative pain and neck discomfort after open thyroidectomy: A scoping review

et al. 2023

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Adequate pain control enhances patients' quality of life and allows a quick return to normal activities. Current pain management practices may contribute to the crisis of opioid addiction. We summarize the evidence that evaluates locoregional interventions to decrease pain and neck discomfort after thyroidectomy. We designed a scoping review. The search strategy was made in the Pubmed/MEDLINE and EMBASE database. We included only systematic reviews and RCTs that compared two or more strategies. Forty‐nine publications including 5045 patients fulfilled criteria. Sore throat frequency is higher for endotracheal intubation and topical administration of anesthetic before intubation decreases this. Pre‐incisional infiltration of the surgical wound decreases postoperative pain. Bilateral superficial plexus nerve block decreases analgesic requirements during and after thyroidectomy. Wound massage and neck exercises decrease postoperative discomfort. Locoregional interventions significantly impact postoperative pain and may reduce opioid use and improve patient outcomes.

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Section: Intubation Maneuvers To Prevent Sore Throatmentioning

confidence: 99%

Locoregional strategies to decrease postoperative pain and neck discomfort after open thyroidectomy: A scoping review

et al. 2023

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“…However, nasal irritation may precipitate bouts of cough or sneezing. [ 33 ] Sneezing may also reduce the absorption of the drug. Droplet sizes produced by the nebulising device influence the absorption of the nebulised drug.…”

Section: Paediatric Premedication - Routes Of Administration Of Drugsmentioning

confidence: 99%

Search for the ideal route of premedication in children.. far from over?

Sengupta¹,

Bhattacharya

Nag

et al. 2022

Indian Journal of Anaesthesia

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“… 108 Several other studies have indicated the ability of dexmedetomidine to prevent or reduce the incidence and severity intubation-related sore throat, 109 including intraoperative infusion, 110 and preoperative nebulization. 111 …”

Section: Clinical Effectsmentioning

confidence: 99%

Recent Advances in the Clinical Value and Potential of Dexmedetomidine

Liu¹,

Li²,

Kang³

et al. 2021

JIR

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Dexmedetomidine, a highly selective α2-adrenoceptor agonist, has sedative, anxiolytic, analgesic, sympatholytic, and opioid-sparing properties and induces a unique sedative response which shows an easy transition from sleep to wakefulness, thus allowing a patient to be cooperative and communicative when stimulated. Recent studies indicate several emerging clinical applications via different routes. We review recent data on dexmedetomidine studies, particularly exploring the varying routes of administration, experimental implications, clinical effects, and comparative advantages over other drugs. A search was conducted on the PubMed and Web of Science libraries for recent studies using different combinations of the words “dexmedetomidine”, “route of administration”, and pharmacological effect. The current routes, pharmacological effects, and application categories of dexmedetomidine are presented. It functions by stimulating pre- and post-synaptic α2-adrenoreceptors within the central nervous system, leading to hyperpolarization of noradrenergic neurons, induction of an inhibitory feedback loop, and reduction of norepinephrine secretion, causing a sympatholytic effect, in addition to its anti-inflammation, sleep induction, bowel recovery, and sore throat reduction effects. Compared with similar α2-adrenoceptor agonists, dexmedetomidine has both pharmacodynamics advantage of a significantly greater α2:α1-adrenoceptor affinity ratio and a pharmacokinetic advantage of having a significantly shorter elimination half-life. In its clinical application, dexmedetomidine has been reported to present a significant number of benefits including safe sedation for various surgical interventions, improvement of intraoperative and postoperative analgesia, sedation for compromised airways without respiratory depression, nephroprotection and stability of hypotensive hemodynamics, reduction of postoperative nausea and vomiting and postoperative shivering incidence, and decrease of intraoperative blood loss. Although the clinical application of dexmedetomidine is promising, it is still limited and further research is required to enhance understanding of its pharmacological properties, patient selection, dosage, and adverse effects.

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Dexmedetomidine nebulisation attenuates post-operative sore throat in patients undergoing thyroidectomy: A randomised, double-blind, comparative study with nebulised ketamine

Cited by 16 publications

References 24 publications

Locoregional strategies to decrease postoperative pain and neck discomfort after open thyroidectomy: A scoping review

Locoregional strategies to decrease postoperative pain and neck discomfort after open thyroidectomy: A scoping review

Search for the ideal route of premedication in children.. far from over?

Recent Advances in the Clinical Value and Potential of Dexmedetomidine

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