Dextran‐Based Antibacterial Hydrogel Dressings for Accelerating Infected Wound Healing by Reducing Inflammation Levels

Abstract

Infected wounds pose challenges such as exudate management, bacterial infections, and persistent inflammation, making them a significant challenge for modern dressings. To address these issues in infected wounds more effectively, we have developed aerogel‐hydrogel biphase gels (AHB‐gel) based on Dextran (Dex). The gel introduced in this study exhibits antibacterial and anti‐inflammatory properties in the process of wound therapy, contributing to accelerate wound healing. The aerogel phase exhibits exceptional water‐absorption capabilities, rapidly soaking up exudate from infected wound, thereby fostering a clean and hygienic wound healing microenvironment. Concurrently, the aerogel phase is enriched with hydrogen sulfide donors. Following water absorption and the formation of the hydrogel phase, it enables the sustained release of hydrogen sulfide around the wound sites. The experiments confirmed that hydrogen sulfide, by promoting M2 macrophage differentiation and reducing the levels of inflammatory factors IL‐6 and TNF‐α, effectively diminishes local inflammation levels at the wound site. Furthermore, the sodium copper chlorophyllin (SCC) component within the hydrogel phase demonstrates effective antibacterial properties through photodynamic antimicrobial therapy (PAT), providing a viable solution to wound infection challenges.This article is protected by copyright. All rights reserved