Dextran-based hydrogel containing chitosan microparticles loaded with growth factors to be used in wound healing

Ribeiro, Maximiano P.; Morgado, Patrícia I.; Miguel, Sónia P.; Coutinho, Paula; Correia, Ilídio J.

doi:10.1016/j.msec.2013.03.025

Cited by 154 publications

(88 citation statements)

References 40 publications

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“…In order to evaluate the cytotoxic profile of the scaffolds, an MTS assay was performed, using a method previously developed at our lab [40]. Briefly, all scaffolds were placed in a 96-well plate (n = 5) and irradiated with ultraviolet (UV) light for 30 min.…”

Section: Evaluation Of Cell Viability In the Presence Of The Scaffoldsmentioning

confidence: 99%

Production and characterization of chitosan/gelatin/β-TCP scaffolds for improved bone tissue regeneration

Serra

Fradique

Vallejo

et al. 2015

Materials Science and Engineering: C

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138

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Section: Evaluation Of Cell Viability In the Presence Of The Scaffoldsmentioning

confidence: 99%

Production and characterization of chitosan/gelatin/β-TCP scaffolds for improved bone tissue regeneration

Serra

Fradique

Vallejo

et al. 2015

Materials Science and Engineering: C

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138

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“…The treatment group treated with oxidized dextran loaded with microparticles containing EGF+VEGF wound closure was observed earlier. They concluded that no specific inflammation or reactive granulomas were found because of the presence of oxidized dextran CS and growth factors in all groups and both growth factors were contributed in wound healing [128]. The slow wound healing was observed in growth factors absent groups, single growth factor added groups compared with two growth factors added groups that improve the establishment of the regenerative cascade in order to produce new extracellular matrix and promote angiogenesis that are fundamental for skin regeneration [129].…”

Section: Wound Dressings With Chitosan and Growth Factorsmentioning

confidence: 99%

Chitosan: A Potential Therapeutic Dressing Material for Wound Healing

Archana

Dutta

2015

Springer Series on Polymer and Composite Materials

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A wide variety of polymers have been used over decades for the preparation of dressing materials for wound healing applications. But the dressing materials based on polysaccharides such as chitosan (CS) have received tremendous attention of the worldwide researchers as a consequence of its important properties like anti-infectional activity, biocompatibility, biodegradability, nontoxicity to mention a few. CS helps in every phase of wound healing such as acting as barrier against microbes, absorbing exudates, accelerates the infiltration of inflammatory cells like neutrophils and helps in healing without scar formation. A reason behind the popularity of CS is that not only it can easily be processed as gels, films, fibers, and scaffolds but also can be blended with natural as well as synthetic polymers to reduce price and improve properties like mechanical, wettability, gas permeability, and handling. Apart from natural and synthetic polymers, CS is also blended with nanoparticles and growth factors to which it shows better antibacterial activity and reduce time span for wound healing. The present chapter aims to focus on feasibility of combining natural polymers, synthetic polymers, nanoparticles, and growth factors with CS for the preparation of wound dressings as basic healthcare materials for regenerative medicine.

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“…Moreover, it is a biorenewable, biodegradable and non-toxic, environmentally friendly product, which can be used as a preventive substance in food system (Rosca et al 2005). It was also successfully used as component of preparation in wound healing (Dai et al 2011;Ribeiro et al 2013). Chitosan is dissolved in most organic acids such as formic acid, acetic acid, lactic acid, and oxalic acids.…”

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confidence: 99%

The use of chitosan, lysozyme, and the nano-silver as antimicrobial ingredients of edible protective hydrosols applied into the surface of meat

Zimoch-Korzycka

Jarmoluk

2014

J Food Sci Technol

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The aim of this study was to design and produce biologically active edible hydrosols, which, when applied to the surface of food products, will protect them from oxidative changes, spoilage and growth of microorganisms. Verification of testing hypothesis and the degree of aim realization were performed by assessing a DPPH radical scavenging activity and microbial reduction of experimental hydrosols on the basis of hydroxypropylmethylcellulose (HPMC), chitosan (CH), lysozyme (L) and nanocolloidal silver (NAg). Antimicrobial activity of different concentrations of CH, L and NAg hydrosols against Gram (+) bacteria: Bacilllus cereus and Micrococcus flavus and Gram (−) bacteria: Escherichia coli and Pseudomonas fluorescens, which exist more often in food, were analyzed using serial dilution test. Total number of microorganisms was determined on meat sample covered by tested sols. Hydrosols containing chitosan and other bioactive substances caused death of each tested microorganism. Lack of chitosan in hydrosols is reflected in a slight inhibition of M. flavus, E. coli and P. fluorescens. Simultaneous influence of CH, L and NAg addition and storage time on total number of bacteria in meat samples with hydrosols was showed. The addition of lysozyme to sols composition significantly increases antioxidant activity.

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Dextran-based hydrogel containing chitosan microparticles loaded with growth factors to be used in wound healing

Cited by 154 publications

References 40 publications

Production and characterization of chitosan/gelatin/β-TCP scaffolds for improved bone tissue regeneration

Production and characterization of chitosan/gelatin/β-TCP scaffolds for improved bone tissue regeneration

Chitosan: A Potential Therapeutic Dressing Material for Wound Healing

The use of chitosan, lysozyme, and the nano-silver as antimicrobial ingredients of edible protective hydrosols applied into the surface of meat

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