Dextran-protamine polycation: An efficient nonviral and haemocompatible gene delivery system

Thomas, Jane Joy; Rekha, M.R.; Sharma, Chandra P.

doi:10.1016/j.colsurfb.2010.07.015

Cited by 42 publications

(21 citation statements)

References 41 publications

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“…Up to now, some cationic dextran derivatives have been synthesized and investigated for gene delivery. For example, Li et al (2013) prepared dextrangraft-poly((2-dimethyl amino)ethyl methacrylate) as an efficient delivery system for tumor gene therapy; Thomas, Rekha, and Sharma (2010) prepared cationic dextran-protamine conjugate as a haemocompatible and nonviral gene vector; Yeo et al (2014) conjugated spermine onto dextran for delivering gene to the lung of mouse via intranasal route. However, the efficiency of gene delivery by these cationic dextran derivatives is still relatively low when compared to commonly used polyethylenimine (PEI) or cationic lipids.…”

Section: Introductionmentioning

confidence: 99%

Water soluble cationic dextran derivatives containing poly(amidoamine) dendrons for efficient gene delivery

Mai

Zhang

Liang

et al. 2015

Carbohydrate Polymers

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Section: Introductionmentioning

confidence: 99%

Water soluble cationic dextran derivatives containing poly(amidoamine) dendrons for efficient gene delivery

Mai

Zhang

Liang

et al. 2015

Carbohydrate Polymers

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“…Entry of the plasmid into the nucleus was also increased. 14 Recently, superoxide dismutase 1 (SOD1) was conjugated with LMWP and the effect of LMWP-SOD1 conjugates on hydrogen peroxide-induced cellular senescence and osteoblastic differentiation was investigated. 15 LMWP-SOD1 signifi cantly increased senescence-associated β -galactosidase activity with enlargement and fl attening of human dental pulp stem cell (DPSC) morphology.…”

Section: Protamine Nanoparticles For Gene Deliverymentioning

confidence: 99%

Protamine nanoparticles

Nimesh¹

2013

Gene Therapy

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“…Cationic polymers represent an interesting class of vectors in plasmid DNA delivery formulations. Various cationic polymers including synthetic amino acid polymers such as poly(1-lysine) and polyethyleneimine (PEI), natural DNAbinding proteins such as histones, carbohydrate-based polymers such as chitosan and various dextran derivatives have been reported (Thomas, 2010b).…”

Section: Nanoplex For Gene Deliverymentioning

confidence: 99%

A review of nanotechnology with an emphasis on Nanoplex

Kadam

Shendge

Pande

2015

Braz. J. Pharm. Sci.

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The use of nanotechnology based on the development and fabrication of nanostructures is one approach that has been employed to overcome the challenges involved with conventional drug delivery systems. Formulating Nanoplex is the new trend in nanotechnology. A nanoplex is a complex formed by a drug nanoparticle with an oppositely charged polyelectrolyte. Both cationic and anionic drugs form complexes with oppositely charged polyelectrolytes. Compared with other nanostructures, the yield of Nanoplex is greater and the complexation efficiency is better. Nanoplex are also easier to prepare. Nanoplex formulation is characterized through the production yield, complexation efficiency, drug loading, particle size and zeta potential using scanning electron microscopy, differential scanning calorimetry, X-ray diffraction and dialysis studies. Nanoplex have wide-ranging applications in different fields such as cancer therapy, gene drug delivery, drug delivery to the brain and protein and peptide drug delivery.Uniterms: Nanotechnology. Nanoplex/formulation. Nanoplex/characterization. Nanoplex/applications O uso da nanotecnologia baseada no desenvolvimento e na fabricação de nanoestruturas é uma abordagem que tem sido empregada para superar os desafios envolvidos nos sistemas de liberação de fármacos convencionais. A formulação de nanoplexos é a nova tendência na nanotecnologia. Um nanoplexo é um complexo formado pela nanopartícula do fármaco com poplieletrólito de carga oposta. Tanto fármacos catiônicos quanto aniônicos formam complexos com polieletrólitos opostamente carregados. Comparado com outras nanoestruturas, o rendimento dos nanoplexos é maior e a eficiência de complexação é melhor. Nanoplexos são, também. De mais fácil preparação. A formulação de nanoplexo é caracterizada pelo rendimento de produção, eficiência de complexação, carga do fármaco, tamanho de partícula e potencial zeta, utilizando microscopia eletrônica de varredura, calorimetria exploratória diferencial, difração de raios X e estudos de diálise. Os nanoplexos têm aplicações amplas em diferentes campos, como terapia antineoplásica, liberação em terapia gênica, liberação cerebral de fármaco, liberação de fármacos protéicos e peptídicos.Unitermos: Nanotecnologia. Nanoplexos/formulação. Nanoplexos/caracterização. Nanoplexos/ aplicações.

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Dextran-protamine polycation: An efficient nonviral and haemocompatible gene delivery system

Cited by 42 publications

References 41 publications

Water soluble cationic dextran derivatives containing poly(amidoamine) dendrons for efficient gene delivery

Water soluble cationic dextran derivatives containing poly(amidoamine) dendrons for efficient gene delivery

Protamine nanoparticles

A review of nanotechnology with an emphasis on Nanoplex

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