Dextroamphetamine with Morphine for the Treatment of Postoperative Pain

Forrest, William H.; Brown, Byron W.; Brown, Colin R.; Défalque, Ray J.; Gold, Martin I.; Gordon, H. Earl; James, Kenneth E.; Katz, Jordan; Mahler, D. Luke; Schroff, P.; Teutsch, Grete

doi:10.1097/00132586-198008000-00069

Cited by 14 publications

(17 citation statements)

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“…Previously, we have found that induction of diabetes in the rat was associated with an elevated brain 5HT level (Kolta et al 1986). The potentiating effect of sympathomimetic amines such as d-amphetamine on opioid antinociceptive activity has been observed in mice (Dewey et al 1970) and humans (Forrest et al 1977). More recently, the alpha adrenergic agonist clonidine and morphine were shown to potentiate each other in the mouse tail flick test (Spaulding et al 1979).…”

Section: Discussionmentioning

confidence: 97%

Hyperglycemic suppression of morphine withdrawal signs in the rat

Akunne

Soliman

1988

Psychopharmacology

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Male Sprague-Dawley rats maintained under controlled lighting and temperature conditions were used in this experiment. Morphine dependency was induced by giving increasing doses of morphine by intraperitoneal injection (IP group) or by the ingestion of morphine through drinking water (PO group). Animals were injected with 10, 20, 30 and 50 mg/kg morphine sulfate at days 1, 2, 3 and 4, respectively. Another group of animals received increasing concentrations of morphine through drinking water from 0.1, 0.2, 0.3 to 0.4 mg/ml at 48 h intervals. Morphine dependent animals were given naloxone by the intraperitoneal route to precipitate withdrawal. Glucose (3 g/kg or 10 g/kg) was given 10 min prior to the administration of naloxone to the respective groups. Another two groups of animals were made diabetic by the administration of streptozotocin. In one group, animals received increasing concentrations of 10, 20, 30 and 50 mg/kg morphine sulfate by the IP route at days 1, 2, 3 and 4, while the other group was not treated with morphine but was assessed for withdrawal signs to serve as the control. Withdrawal signs were assessed by observing the presence of diarrhea, tremor, piloerection, hunchbacked posture, teeth chattering, salivation, erection, restless activity, territorial exploring, irritability to handling, vocalization and jumping. Results obtained indicate that glucose administration at 10 g/kg abolished most of the withdrawal signs, and we were unable to induce the same degree of morphine dependency in diabetic animals as compared to the non-diabetic groups. It was concluded from this study that hyperglycemia could suppress morphine withdrawal signs.

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Section: Discussionmentioning

confidence: 97%

Hyperglycemic suppression of morphine withdrawal signs in the rat

Akunne

Soliman

1988

Psychopharmacology

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“…While it has not been demonstrated clinically that central nervous system stimulants alone have analgesic properties, d-amphetamine is known to increase the analgesic action of morphine 9 and caffeine has been shown to increase the analgesic action of aspirin.3 Both also increase performance on a wide variety of tests ll • 12. 20 in addition to their well-known pharmacologic effects on the cardiovascular system.…”

Section: Discussionmentioning

confidence: 99%

Effects of nefopam on visual tracking

Dorey

1979

Clin Pharma and Therapeutics

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“…Ils permettent notamment de potentialiser l'effet analgésique des opioïdes 19,20 et de contrer leur effet sédatif indésirable 21,22 , de traiter la fatigue [22][23][24] et la dépression 25,26 . En outre, des études rapportent qu'ils amélioreraient les fonctions cognitives des patients atteints d'une tumeur cérébrale 27,28 ou du syndrome associé au sida (AIDS-related complex) [29][30][31] , ce qui suggère que les psychostimulants pourraient s'avérer profitables pour améliorer les fonctions cognitives des patients en delirium hypoactif.…”

Section: Limitationsunclassified