DGCR5 induces osteogenic differentiation by up-regulating Runx2 through miR-30d-5p

Wu, Zhihao; Huang, Kai; Liu, Kang; Wang, Guantong; Sun, Qiang

doi:10.1016/j.bbrc.2018.09.033

Cited by 26 publications

(17 citation statements)

References 23 publications

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“…Thus, by targeting miR-498, GAS5 could promote bone formation (Feng et al, 2019). Similarly, the study by Wu et al reports the upregulation of lncRNA DiGeorge syndrome critical region gene 5 (DGCR5) in hMSCs derived from PMOP patients could promote hMSCs to differentiate to osteoblasts, increasing Runx2 expression though miR-30d-5p (Wu et al, 2018c).…”

Section: Lncrna Involved In Bmsc Regulation Through Mirnamentioning

confidence: 89%

Role of LncRNAs and CircRNAs in Bone Metabolism and Osteoporosis

et al. 2020

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Section: Lncrna Involved In Bmsc Regulation Through Mirnamentioning

confidence: 89%

Role of LncRNAs and CircRNAs in Bone Metabolism and Osteoporosis

et al. 2020

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“…Therefore, deeply knowledge of the mechanisms which govern BMSCs differentiation is of pivotal relevance. Currently, different lncRNA/miRNA axes have been found positive regulator of osteogenesis in BMSCs, such as lncH19/miR-675, lncH19/miR-22-miR-141, lncH19/miR-138, lncH19/miR-188, KCNQ1OT1/miR-214, KCNQ1OT1/miR-320a, LOC103691336/miR-138-5p, NEAT1/miR-29b-3p, MALA-T1/miR-143, lncRNA LINC00707/miR-370-3p, LINC0 0707/miR-145, FAM83H-AS1/miR-541-3p, Linc-ROR/miR-138-miR-145, HULC/miRNA-195, XIXT/miRNA-30a-5p, DGCR5/miR-30d-5p, TCONS_00041960/miR-204-5p, TCONS_ 00041960/miR-125a-3p (Huang et al, 2015;Liang et al, 2016;Wang et al, 2017Wang et al, , 2018Wang et al, , 2020Wei et al, 2017;Feng et al, 2018;Gao et al, 2018;Jiang et al, 2018;Shang et al, 2018;Wu J. et al, 2018;Wu Z.-H. et al, 2018;Jia et al, 2019a;Wang C.-G. et al, 2019;Zhang H.-L. et al, 2019;Cai et al, 2020;Wu et al, 2020). By contrast, HOTAIR/miR-17-5p and MEG3/miR-133a-3p have been found to be negative regulators of BMSCs osteogenesis (Wang et al, 2017;Wei et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…Irrespective of the osteogenic pathways, the lncRNAs XIXT and DGCR5 have been found to positively regulate BMSC osteogenic differentiation by directly acting on miRNAs targeting RUNX2, the master osteogenic transcription factor (Draper et al, 2016;Wu Z.-H. et al, 2018;Zhang H.-L. et al, 2019). XIXT and DGCR5 can trigger osteogenesis by sponging the miRNA-30a-5p and miR-30d-5p, respectively.…”

Section: Lncrnas/mirnas Crosstalk In Osteogenic Differentiation Of Bone Marrow Mesenchymal Stem Cellsmentioning

confidence: 99%

Long Non-coding RNAs and MicroRNAs Interplay in Osteogenic Differentiation of Mesenchymal Stem Cells

Lanzillotti

Mattei

Mazziotta

et al. 2021

Front. Cell Dev. Biol.

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Long non-coding RNAs (lncRNAs) have gained great attention as epigenetic regulators of gene expression in many tissues. Increasing evidence indicates that lncRNAs, together with microRNAs (miRNAs), play a pivotal role in osteogenesis. While miRNA action mechanism relies mainly on miRNA-mRNA interaction, resulting in suppressed expression, lncRNAs affect mRNA functionality through different activities, including interaction with miRNAs. Recent advances in RNA sequencing technology have improved knowledge into the molecular pathways regulated by the interaction of lncRNAs and miRNAs. This review reports on the recent knowledge of lncRNAs and miRNAs roles as key regulators of osteogenic differentiation. Specifically, we described herein the recent discoveries on lncRNA-miRNA crosstalk during the osteogenic differentiation of mesenchymal stem cells (MSCs) derived from bone marrow (BM), as well as from different other anatomical regions. The deep understanding of the connection between miRNAs and lncRNAs during the osteogenic differentiation will strongly improve knowledge into the molecular mechanisms of bone growth and development, ultimately leading to discover innovative diagnostic and therapeutic tools for osteogenic disorders and bone diseases.

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“…Furthermore, the high expression of miR-30d-5p weakened granuloma cell proliferation via targeting Smad2 (Yu and Liu, 2020). Wu et al, 2018 established that DGCR5 upregulated the level of Runx2 via miR-30d-5p and induced the osteoblast differentiation in human mesenchymal stem cells. In general, miR-30d-5p has been strongly connected with cell proliferation in various cancers.…”

Section: Cell Proliferationmentioning

confidence: 96%

“…Jiang et al, 2018 found that exosomes loaded with miR-30d-5p reversed ischemia-induced autophagy-mediated brain damage via facilitating M2 microglia polarization, which is a feasible direction towards mitigating brain injury. Moreover, a recent study reported that various miRNAs, especially miR-30d-5p, were downregulated in brain hypoxia-ischemia (HI) (Wu et al, 2018). miR-30d-5p targeted the 3′-UTR site of Beclin1 mRNA and participated in autophagy in a newborn rat HI brain via regulating Beclin1.…”

Section: Cell Autophagy and Apoptosismentioning

confidence: 99%

miR-30d-5p: A Non-Coding RNA With Potential Diagnostic, Prognostic and Therapeutic Applications

Zhao

Yuan

Zheng

et al. 2022

Front. Cell Dev. Biol.

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Cancer is a great challenge facing global public health. Scholars have made plentiful efforts in the research of cancer therapy, but the results are still not satisfactory. In relevant literature, the role of miRNA in cancer has been widely concerned. MicroRNAs (miRNAs) are a non-coding, endogenous, single-stranded RNAs that regulate a variety of biological functions. The abnormal level of miR-30d-5p, a type of miRNAs, has been associated with various human tumor types, including lung cancer, colorectal cancer, esophageal cancer, prostate cancer, liver cancer, cervical cancer, breast cancer and other types of human tumors. This reflects the vital function of miR-30d-5p in tumor prognosis. miR-30d-5p can be identified either as an inhibitor hindering the development of, or a promoter accelerating the occurrence of tumors. In addition, the role of miR-30d-5p in cell proliferation, motility, apoptosis, autophagy, tumorigenesis, and chemoresistance are also noteworthy. The multiple roles of miR-30d-5p in human cancer suggest that it has broad feasibility as a biomarker and therapeutic target. This review describes the connection between miR-30d-5p and the clinical indications of tumors, and summarizes the mechanisms by which miR-30d-5p mediates cancer progression.

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DGCR5 induces osteogenic differentiation by up-regulating Runx2 through miR-30d-5p

Cited by 26 publications

References 23 publications

Role of LncRNAs and CircRNAs in Bone Metabolism and Osteoporosis

Role of LncRNAs and CircRNAs in Bone Metabolism and Osteoporosis

Long Non-coding RNAs and MicroRNAs Interplay in Osteogenic Differentiation of Mesenchymal Stem Cells

miR-30d-5p: A Non-Coding RNA With Potential Diagnostic, Prognostic and Therapeutic Applications

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