2023
DOI: 10.1039/d2fo03019e
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DHA-enriched phosphatidylserine alleviates high fat diet-induced jejunum injury in mice by modulating gut microbiota

Abstract: A long-term high-fat diet (HFD) is one of the high-risk factors for intestinal barrier damage. Docosahexaenoic acid-enriched phosphatidylserine (DHA-PS) has multiple biological activities, while its protective effect on HFD-caused jejunum...

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Cited by 26 publications
(12 citation statements)
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“…The liver tissue was immersed in a saturated lithium carbonate solution for 12 h before being washed with tap water as part of the bluing process. Eosin Y solution (HT110116, Sigma-Aldrich) was then used to stain the sample for 48 h [ 15 , 16 ]. The stained fixed sections (4 μm-thick) were observed under the light microscopy (Olympus).…”
Section: Methodsmentioning
confidence: 99%
“…The liver tissue was immersed in a saturated lithium carbonate solution for 12 h before being washed with tap water as part of the bluing process. Eosin Y solution (HT110116, Sigma-Aldrich) was then used to stain the sample for 48 h [ 15 , 16 ]. The stained fixed sections (4 μm-thick) were observed under the light microscopy (Olympus).…”
Section: Methodsmentioning
confidence: 99%
“…Thus, RAs changes of this microbiota could be due to the different stilbene contents in the peanut sprouts of different groups (dark and UV-C). Previous studies revealed that Lachnospiraceae NK4A136 demonstrated a positive correlation with antioxidant enzyme activity (SOD, GSH-Px), 43,47 and however, Parabacteroides was positively correlated with proinflammatory factors and MDA while negatively correlated with SOD activity. 48,49 Besides, Lactobacillus could decrease excessive ROS by decreasing the activity of ROS-producing…”
Section: Food and Function Papermentioning
confidence: 87%
“…Mouse adipose tissue was sliced using a microtome (7 μm), and then H&E staining was used to observe the size and flatness of adipose cells. 22…”
Section: Methodsmentioning
confidence: 99%
“…Mouse adipose tissue was sliced using a microtome (7 μm), and then H&E staining was used to observe the size and flatness of adipose cells. 22 2.9. Fecal microbiota 16S rRNA analysis Samples of mouse cecal contents stored at −80 °C were extracted for genomic DNA by the CTAB or SDS method, and then DNA purity and concentration were determined by agargel electrophoresis.…”
Section: Histopathological Analysismentioning
confidence: 99%