DHA-enriched phospholipids from large yellow croaker roe regulate lipid metabolic disorders and gut microbiota imbalance in SD rats with a high-fat diet

Lu, Xiaodan; Zhong, Rongbin; Hu, Ling; Huang, Luyao; Chen, Lijiao; Cheng, Wenjian; Zheng, Baodong; Peng, Liang

doi:10.1039/d1fo00747e

Cited by 18 publications

(21 citation statements)

References 83 publications

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“…Lu et al. (2021) further showed that DHA‐enriched phospholipids (PL) from large yellow croaker roe could reduce the body weight of rats without affecting their daily food intake, and our results were consistent with these studies.…”

Section: Resultssupporting

confidence: 90%

“…Similarly, Gao et al (2021) showed that EPA/DHAphosphatidylcholine (PC) from squid roes could reduce the body weight of mice without affecting their daily food intake. Lu et al (2021) further showed that DHA-enriched phospholipids (PL) from large yellow croaker roe could reduce the body weight of rats without affecting their daily food intake, and our results were consistent with these studies.…”

Section: Effect Of Dha-ps On Body Weight Gain and Food Intake Of Micesupporting

confidence: 89%

“…Accumulating evidence suggests that excess lipid deposition and lipid toxicity play a vital role in the pathogenic mechanism of HFD‐induced kidney injury (Bulbul et al., 2018; De Vries et al., 2014). Accumulating evidence suggests that the dietary DHA‐PS ( Clupea harengus roe), EPA/DHA‐PC (squid roe), or DHA‐enriched phospholipids (large yellow croaker roe) have a positive effect on reducing serum TC, TG, or NEFA levels in the HFD‐induced mice or rats (Gao et al., 2021; Lu et al., 2021; Zhou, Tian, et al., 2021). Moreover, Zhang et al.…”

Section: Resultsmentioning

confidence: 99%

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DHA‐enriched phosphatidylserine ameliorates high‐fat diet‐induced kidney injury in mice possibly by regulating TLR4/NF‐κB and AMPK pathways

Zhou

Tian

Wang³

et al. 2022

Journal of Food Science

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The present study sought to investigate the amelioration effects of enzymatically synthesized docosahexaenoic acid-enriched phosphatidylserine (DHA-PS) on the high-fat diet (HFD)-induced kidney injury in mice. After 6 weeks of DHA-PS intervention, the mice's body weight in the 20 and 40 mg/kg DHA-PS groups decreased by 7.09% and 9.71%, respectively, compared to the HFD group. Especially, compared to the HFD group, 40 mg/kg DHA-PS treatment effectively reduced the levels of serum urea nitrogen by 68.48%, creatinine by 38.98%, kidney lipid accumulation (total cholesterol, triglycerides, and nonesterified fatty acids levels by 26.19%, 51.00%, and 26.11%), kidney or serum proinflammatory cytokines and enhanced the levels of kidney or serum oxidative stress parameters, except for malondialdehyde (MDA). Moreover, 40 mg/kg DHA-PS treatment decreased the expression levels of toll-like receptor 4 (TLR4)

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Section: Resultssupporting

confidence: 90%

Section: Effect Of Dha-ps On Body Weight Gain and Food Intake Of Micesupporting

confidence: 89%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

DHA‐enriched phosphatidylserine ameliorates high‐fat diet‐induced kidney injury in mice possibly by regulating TLR4/NF‐κB and AMPK pathways

Zhou

Tian

Wang³

et al. 2022

Journal of Food Science

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“…Moreover, several studies have also proved that marine phospholipids exert anti-obesity effects. For example, Lu et al reported that phospholipids from large yellow croaker roe could regulate lipid metabolism, and improve gut microbiota disorder in HFD-fed rats [ 29 ]. Phospholipids from krill oil were proved to lower body weight gain, mesenteric adipose tissue, and hepatic lipid content [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Obesity and Gut Microbiota Regulation Effects of Phospholipids from the Eggs of Crab, Portunus Trituberculatus, in High Fat Diet-Fed Mice

Zhu

Chen

et al. 2022

Marine Drugs

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There are resourceful phospholipids in the eggs of the crab, Portunus trituberculatus (Pt-PL). However, their components and bioactivities regarding obesity were unclear. Here, we investigated the composition of Pt-PL and their fatty acids. Moreover, its effects on obesity and gut microbiota were also evaluated in high fat diet (HFD)-fed mice. The results showed that Pt-PL contained 12 kinds of phospholipids, mainly including phosphatidylcholine (PC, 32.28%), phosphatidylserine (PS, 26.51%), phosphatidic acid (PA, 19.61%), phosphatidylethanolamine (PE, 8.81%), and phosphatidylinositol (PI, 7.96%). Polyunsaturated fatty acids (PUFAs) predominated in the fatty acids components of Pt-PL, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Animal experiments demonstrated that Pt-PL significantly alleviated body weight gain, adipose gain, hepatic gain, fasting blood glucose, serum insulin, lipid levels in serum and the liver, and systematic inflammation in HFD-fed mice. Furthermore, Pt-PL regulated gut microbiota, especially in a dramatic reduction in the ratio of Firmicutes to Bacteroidetes at phylum level, as well as significant amelioration in their subordinate categories. Pt-PL reduced fecal lipopolysaccharide and total bile acids, and elevated fecal short chain fatty acid (SCFA) concentrations, particularly acetate and butyrate. These findings suggest that Pt-PL possesses anti-obesity effects and can alter gut microbiota owing to the abundance of PUFAs. Therefore, Pt-PL may be developed as an effective food supplement for anti-obesity and regulation of human gut health.

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“…Mammalian studies have suggested that appropriate levels of DHA could improve the gut microbiota disorder caused by high-fat diet (HFD) or chronic stress ( 17 – 20 ). The health-promoting effects of DHA, such as alleviating hyperglycemia, insulin resistance, and lipid metabolism abnormalities, are partly mediated by the modulation of gut microbiome and bacterial metabolites ( 21 – 23 ).…”

Section: Introductionmentioning

confidence: 99%

Excess DHA Induces Liver Injury via Lipid Peroxidation and Gut Microbiota-Derived Lipopolysaccharide in Zebrafish

et al. 2022

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Being highly unsaturated, n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) are prone to lipid peroxidation. In this study, zebrafish were fed with low-fat diet (LFD), high-fat diet (HFD), or 2% DHA-supplemented HFD (HFDHA2.0). To study the possible negative effects of the high level of dietary DHA, growth rates, blood chemistry, liver histology, hepatic oxidative stress, apoptosis, and inflammatory processes were assessed. The cell studies were used to quantify the effects of DHA and antioxidant on cellular lipid peroxidation and viability. The possible interaction between gut microbiota and zebrafish host was evaluated in vitro. HFDHA2.0 had no effect on hepatic lipid level but induced liver injury, oxidative stress, and hepatocellular apoptosis, including intrinsic and death receptor-induced apoptosis. Besides, the inclusion of 2% DHA in HFD increased the abundance of Proteobacteria in gut microbiota and serum endotoxin level. In the zebrafish liver cell model, DHA activated intrinsic apoptosis while the antioxidant 4-hydroxy-Tempo (tempo) inhibited the pro-apoptotic negative effects of DHA. The apoptosis induced by lipopolysaccharide (LPS) was unaffected by the addition of tempo. In conclusion, the excess DHA supplementation generates hepatocellular apoptosis-related injury to the liver. The processes might propagate along at least two routes, involving lipid peroxidation and gut microbiota-generated LPS.

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DHA-enriched phospholipids from large yellow croaker roe regulate lipid metabolic disorders and gut microbiota imbalance in SD rats with a high-fat diet

Abstract: Large yellow croaker roe phospholipids (LYCRPLs) has great nutritional value because of containing rich docosahexaenoic acid (DHA), which is a kind of n-3 polyunsaturated fatty acids (n-3 PUFAs). In...

Cited by 18 publications

References 83 publications

DHA‐enriched phosphatidylserine ameliorates high‐fat diet‐induced kidney injury in mice possibly by regulating TLR4/NF‐κB and AMPK pathways

DHA‐enriched phosphatidylserine ameliorates high‐fat diet‐induced kidney injury in mice possibly by regulating TLR4/NF‐κB and AMPK pathways

Anti-Obesity and Gut Microbiota Regulation Effects of Phospholipids from the Eggs of Crab, Portunus Trituberculatus, in High Fat Diet-Fed Mice

Excess DHA Induces Liver Injury via Lipid Peroxidation and Gut Microbiota-Derived Lipopolysaccharide in Zebrafish

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