Diabetes and HIV

Noubissi, Emile Camille; Katte, Jean-Claude; Sobngwi, Eugène

doi:10.1007/s11892-018-1076-3

Cited by 84 publications

(65 citation statements)

References 47 publications

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“…16 Lactic acidosis, a rare but serious adverse effect, must be taken into consideration when metformin is coadministered with dolutegravir, an integrase inhibitor, due to the significant increase in metformin concentration levels. 5 It is also associated with moderate gastrointestinal effects, vitamin B 12 deficiency with long-term use, 6 and is contraindicated if the estimated glomerular filtration rate is < 30 mL/min/1.73 m 2 . 19 Some other contraindications for metformin that would predispose an individual to lactic acidosis include hypoxia or hypoperfusion, active or progressive liver disease, unstable or acute congestive heart failure, active alcohol abuse, and history of lactic acidosis.…”

Section: Managing T2dm In the Presence Of Artmentioning

confidence: 99%

“…There is a disease-related link and ART-related link between HIV infection and dyslipidemia. 4,5,11 Dyslipidemia and T2DM contribute to serious cardiovascular risk considerations, because PLWH are 2 times more likely to be at risk for acute myocardial infarction compared with the general population. 4 In addition to traditional risk factors of atherosclerotic cardiovascular disease (ASCVD), HIV infection is associated with elevated ASCVD risk.…”

Section: Managing Dyslipidemiamentioning

confidence: 99%

“…4 There are established links among HIV, ART, metabolic dysfunction, insulin resistance, T2DM, dyslipidemia, and cardiovascular disease. 4,5 The pathogenesis of HIV-associated metabolic dysfunction has been described as complex and multifactorial. 4 A variety of interacting factors have been identified, including HIV infection, adverse effects of ART, immune dysfunction, inflammation, and traditional age-related risk factors.…”

mentioning

confidence: 99%

“…4 ART is associated with increased risk of prediabetes and T2DM, 6 and the weight gain associated with some ART regimens can compound metabolic dysfunction. 5 Whether treated or untreated, the presence of HIV results in a higher prevalence of diabetes compared with those without HIV. 5 HIV is an independent risk factor for cardiovascular disease due to mechanisms associated with ART, dyslipidemia, immune dysfunction, and systemic inflammation.…”

mentioning

confidence: 99%

“…5 Whether treated or untreated, the presence of HIV results in a higher prevalence of diabetes compared with those without HIV. 5 HIV is an independent risk factor for cardiovascular disease due to mechanisms associated with ART, dyslipidemia, immune dysfunction, and systemic inflammation. 7 Inflammation has a number of potential root causes.…”

mentioning

confidence: 99%

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Pharmacologic Management of Human Immunodeficiency Virus and Common Chronic Conditions

Pitts¹,

Anthamatten²

2020

The Journal for Nurse Practitioners

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There has been an evolution in the care and survival of people living with human immunodeficiency virus (PLWH) and AIDS. Increased survival of PLWH is attributed to antiretroviral therapy. However, adverse effects of antiretroviral therapy increase the likelihood that PLWH may also be diagnosed with chronic conditions such as diabetes mellitus, hypertension, and dyslipidemia. Drug-drug interactions are common when coadministering human immunodeficiency virus drugs and therapies for common chronic conditions managed in primary care. To prevent adverse events, nurse practitioners should know about these interactions before prescribing new regimens or modifying a regimen.

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Section: Managing T2dm In the Presence Of Artmentioning

confidence: 99%

Section: Managing Dyslipidemiamentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Pharmacologic Management of Human Immunodeficiency Virus and Common Chronic Conditions

Pitts¹,

Anthamatten²

2020

The Journal for Nurse Practitioners

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Metabolic Syndrome and Cardiovascular Disease Impacts on the Pathophysiology and Phenotype of HIV-Associated Neurocognitive Disorders

Moulignier¹,

Costagliola²

2020

Current Topics in Behavioral Neurosciences

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Evidence from epidemiological studies on the general population suggests that midlife cardiovascular disease (CVD) and/or metabolic syndrome (MetS) are associated with an increased risk of cognitive impairment and dementia later in life. In the modern combined antiretroviral therapy (cART) era, as in the general population, CVD and MetS were strongly and independently associated with poorer cognitive performances of sustained immunovirologically controlled persons living with human immunodeficiency viruses (PLHIVs). Those findings suggest that CV/metabolic comorbidities could be implicated in the pathogenesis of HIV-associated neurocognitive disorders (HAND) and might be more important

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Diabetes and infection: review of the epidemiology, mechanisms and principles of treatment

Holt,

Cockram,

et al. 2024

Diabetologia

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An association between diabetes and infection has been recognised for many years, with infection being an important cause of death and morbidity in people with diabetes. The COVID-19 pandemic has re-kindled an interest in the complex relationship between diabetes and infection. Some infections occur almost exclusively in people with diabetes, often with high mortality rates without early diagnosis and treatment. However, more commonly, diabetes is a complicating factor in many infections. A reciprocal relationship occurs whereby certain infections and their treatments may also increase the risk of diabetes. People with diabetes have a 1.5- to 4-fold increased risk of infection. The risks are the most pronounced for kidney infection, osteomyelitis and foot infection, but are also increased for pneumonia, influenza, tuberculosis, skin infection and general sepsis. Outcomes from infection are worse in people with diabetes, with the most notable example being a twofold higher rate of death from COVID-19. Hyperglycaemia has deleterious effects on the immune response. Vascular insufficiency and neuropathy, together with altered skin, mucosal and gut microbial colonisation, contribute to the increased risk of infection. Vaccination is important in people with diabetes although the efficacy of certain immunisations may be compromised, particularly in the presence of hyperglycaemia. The principles of treatment largely follow those of the general population with certain notable exceptions. Graphical Abstract

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Diabetes and HIV

Cited by 84 publications

References 47 publications

Pharmacologic Management of Human Immunodeficiency Virus and Common Chronic Conditions

Pharmacologic Management of Human Immunodeficiency Virus and Common Chronic Conditions

Metabolic Syndrome and Cardiovascular Disease Impacts on the Pathophysiology and Phenotype of HIV-Associated Neurocognitive Disorders

Diabetes and infection: review of the epidemiology, mechanisms and principles of treatment

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