Diabetes as a risk factor for herpes zoster in adults: A synthetic literature review

Saadatian‐Elahi, Mitra; Bauduceau, B.; Del-Signore, Corinne; Vanhems, Philippe

doi:10.1016/j.diabres.2019.107983

Cited by 24 publications

(19 citation statements)

References 60 publications

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“…Our work suggests that redox modification of STING is an important mechanism for regulating STING activity, which may explain how herpesviruses manipulate STING signaling and reduce interferon levels to support their replication. Notably, elevated ROS levels in the context of viral infection is of high clinical relevance, as ROS is increased in elderly people as well as in many diseases, including cardiovascular diseases, lung fibrosis, diabetes mellitus and cancer ( Kurundkar and Thannickal, 2016 ; Ma et al, 2013 ; Ma et al, 2013 ; Di Pietro et al, 2017 ; Saadatian-Elahi et al, 2020 ). This suggests that antiviral responses in these individuals could be repressed, leading to impaired control of chronic herpesvirus infections and poor clinical outcomes ( Stowe et al, 2007 ; Ye et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Reactive oxygen species oxidize STING and suppress interferon production

Tao

Lemoff

Zarek

et al. 2020

eLife

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Reactive oxygen species (ROS) are by-products of cellular respiration that can promote oxidative stress and damage cellular proteins and lipids. One canonical role of ROS is to defend the cell against invading bacterial and viral pathogens. Curiously, some viruses, including herpesviruses, thrive despite the induction of ROS, suggesting that ROS are beneficial for the virus. However, the underlying mechanisms remain unclear. Here, we found that ROS impaired interferon response during murine herpesvirus infection and that the inhibition occurred downstream of cytoplasmic DNA sensing. We further demonstrated that ROS suppressed the type I interferon response by oxidizing Cysteine 147 on murine stimulator of interferon genes (STING), an ER-associated protein that mediates interferon response after cytoplasmic DNA sensing. This inhibited STING polymerization and activation of downstream signaling events. These data indicate that redox regulation of Cysteine 147 of mouse STING, which is equivalent to Cysteine 148 of human STING, controls interferon production. Together, our findings reveal that ROS orchestrates anti-viral immune responses, which can be exploited by viruses to evade cellular defenses.

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Section: Discussionmentioning

confidence: 99%

Reactive oxygen species oxidize STING and suppress interferon production

Tao

Lemoff

Zarek

et al. 2020

eLife

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“…The serious and highly painful phase of this infection is referred to as shingles. A common feature of shingles and other viral infections is that they are often most severe in immunocompromised patients (40,41), a condition that may be rectified by melatonin (42).…”

Section: Melatonin/virus Interactionsmentioning

confidence: 99%

Treatment of ebola and other infectious diseases: melatonin “goes viral”

Reíter

Sharma

2020

Melatonin Res.

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This review summarizes published reports on the utility of melatonin as a treatment for virus-mediated diseases. Of special note are the data related to the role of melatonin in influencing Ebola virus disease. This infection and deadly condition has no effective treatment and the published works documenting the ability of melatonin to attenuate the severity of viral infections generally and Ebola infection specifically are considered. The capacity of melatonin to prevent one of the major complications of an Ebola infection, i.e., the hemorrhagic shock syndrome, which often contributes to the high mortality rate, is noteworthy. Considering the high safety profile of melatonin, the fact that it is easily produced, inexpensive and can be self-administered makes it an attractive potential treatment for Ebola virus pathology.

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“…Immunosuppression caused by malignancy, HIV infection, and immunosuppressive therapy such as steroids increases the risk for herpes zoster infection [11]. Also, aging and diabetes mellitus were reported to increase the risk of herpes zoster infection [12]. In this case, hypercortisolism caused by SCD made it difficult to maintain normal blood glucose level.…”

Section: Discussionmentioning

confidence: 83%

Severe infection including disseminated herpes zoster triggered by subclinical Cushing’s disease: a case report

et al. 2021

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Background Subclinical Cushing’s disease (SCD) is defined by corticotroph adenoma-induced mild hypercortisolism without typical physical features of Cushing’s disease. Infection is an important complication associated with mortality in Cushing’s disease, while no reports on infection in SCD are available. To make clinicians aware of the risk of infection in SCD, we report a case of SCD with disseminated herpes zoster (DHZ) with the mortal outcome. Case presentation An 83-year-old Japanese woman was diagnosed with SCD, treated with cabergoline in the outpatient. She was hospitalized for acute pyelonephritis, and her fever gradually resolved with antibiotics. However, herpes zoster appeared on her chest, and the eruptions rapidly spread over the body. She suddenly went into cardiopulmonary arrest and died. Autopsy demonstrated adrenocorticotropic hormone-positive pituitary adenoma, renal abscess, and DHZ. Conclusions As immunosuppression caused by SCD may be one of the triggers of severe infection, the patients with SCD should be assessed not only for the metabolic but also for the immunodeficient status.

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Diabetes as a risk factor for herpes zoster in adults: A synthetic literature review

Cited by 24 publications

References 60 publications

Reactive oxygen species oxidize STING and suppress interferon production

Reactive oxygen species oxidize STING and suppress interferon production

Treatment of ebola and other infectious diseases: melatonin “goes viral”

Severe infection including disseminated herpes zoster triggered by subclinical Cushing’s disease: a case report

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