Diabetic neuropathy

Matuszewski, Wojciech; Bandurska-Stankiewicz, Elżbieta; Wiatr-Bykowska, Dorota; Myszka-Podgórska, Katarzyna; Kamińska, Urszula

doi:10.1016/j.poamed.2013.10.001

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…9 Diabetic polyneuropathy (DPN) is the most frequent microvessel complication in type 2 DM patients, developing in nearly 110 million people worldwide. 10 Its prevalence increases approximately 10% one year after DM is diagnosed and can be found in 50%, 25 years after the diagnosis of type 2 DM. 11 Several groups have described the mechanisms of peripheral nerve dysfunction, secondary to oxidative stress-induced damage in DM.…”

Section: Introductionmentioning

confidence: 99%

Effect of statins on oxidative DNA damage in diabetic polyneuropathy

Carrillo-Ibarra

Miranda-Díaz

Sifuentes-Franco

et al. 2018

Journal of Circulating Biomarkers

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Oxidative stress induces nerve damage in type 2 diabetes mellitus and leads to diabetic polyneuropathy (DPN) and can affect the DNA and antioxidant status. Statins have pleiotropic, protective effects on the peripheral nerves of patients with diabetes. The aim of this study was to determine the effects of ezetimibe/simvastatin and rosuvastatin on DNA damage in patients with DPN. This randomized, double-blind, placebo-controlled, clinical trial comprised outpatients from Guadalajara, Mexico. The inclusion criteria were either gender, age 35–80 years, type 2 diabetes, glycated hemoglobin ≤10%, diabetic polyneuropathy stage 1/2, and signed informed consent. Patients who were taking antioxidant therapy or statins, had hypersensitivity to drugs, experienced organ failure, were pregnant or breastfeeding, or had other types of neuropathy were excluded. We assigned patients to placebo, ezetimibe/simvastatin 10/20 mg, or rosuvastatin 20 mg, and the primary outcomes were 8-hydroxy-2′-deoxyguanosine (8-OHdG) for DNA damage, 8-oxoguanine-DNA-N-glycosilase (hOGG1) for DNA repair, and superoxide dismutase (SOD). Seventy-four patients were recruited. Nine patients were included as negative controls. There were no differences in 8-OHdG between the healthy subjects (4.68 [3.53–6.38] ng/mL) and the DPN patients (4.51 [1.22–9.84] ng/mL), whereas the hOGG1 level was 0.39 (0.37–0.42) ng/mL in the healthy subjects and 0.41 (0.38–0.54) ng/mL in patients with DPN at baseline (p = 0.01). SOD decreased significantly in patients with DPN (5.35 [0.01–17.90] U/mL) compared with the healthy subjects (9.81 [8.66–12.61] U/mL) at baseline (p < 0.001). No significant changes in DNA biomarkers were observed in any group between baseline and final levels. We noted a rise in hOGG1 in patients with DPN, without modifications after treatment. There was a slight, albeit insignificant, increase in SOD in patients who were on statins.

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Section: Introductionmentioning

confidence: 99%

Effect of statins on oxidative DNA damage in diabetic polyneuropathy

Carrillo-Ibarra

Miranda-Díaz

Sifuentes-Franco

et al. 2018

Journal of Circulating Biomarkers

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Single-fiber Electromyography in Patients with Diabetic Neuropathy

Kadhim,

Ajeena,

Al-Maamory

2022

Medical Journal of Babylon

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Diabetic peripheral neuropathy (DPN) is the most common microvascular complication of diabetes mellitus. Clinically, it affects the most distal extremities, first resulting in a stock and glove pattern of sensory loss. It affects both small fibers (myelinated and unmyelinated) and large myelinated nerve fibers. However, the earliest manifestations might be due to small fiber dysfunction. The diagnosis of DPN relies largely on typical history and physical examination and supported by the conventional nerve conduction study (NCS) and electromyography (EMG). However, a large number of cases might be missed from diagnosis due to small fiber involvement that manifests before large fibers. This necessitates the use of other diagnostic strategies such as single-fiber EMG, which is helpful in deciphering small fiber dysfunction and DPN earlier than NCS.

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Diabetic neuropathy

Cited by 2 publications

References 27 publications

Effect of statins on oxidative DNA damage in diabetic polyneuropathy

Effect of statins on oxidative DNA damage in diabetic polyneuropathy

Single-fiber Electromyography in Patients with Diabetic Neuropathy

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