Diacidene, a Polyene Dicarboxylic Acid from a Micromonospora Isolate from the German Wadden Sea

Abstract

Micromonospora sp. strain DB620 was isolated from a Wadden Sea sediment sample collected near Büsum (Germany) and is closely related (99% 16S-rRNA gene sequence similarity) to Micromonospora coxensis strain MTCC8093. It produced a new polyene dicarboxylic acid named diacidene (1) and in addition a derivative of chorismic acid, the known 3-[(1-carboxyvinyl)oxy]benzoic acid. The structure elucidation of 1 was achieved by applying different 1D and 2D NMR techniques as well as mass spectrometry and UV spectroscopy.

An Unusual Type II Polyketide Synthase System Involved in Cinnamoyl Lipid Biosynthesis

“…Cinnamoyl lipid (CL) containing compounds, featuring with an ortho ‐substituted cinnamoyl group, constitute a small family of natural products. Up to now, only a handful of CL containing compounds have been reported, such as youssoufenes ( 1 – 5 ), [1] serpentene ( 6 ), [2] diacidene, [3] lahorenoic acids, [4] and cinnamoyl‐containing nonribosomal peptides (CCNPs) (kitacinnamycins, [5] skyllamycins, [6] et al.) (Figures 1 A, S1).…”