Diagnosing Colitis: a Prospective Study on Essential Parameters for Reaching a Diagnosis

Dejaco, Clemens; Oesterreicher, C.; Angelberger, S.; Püspök, Andreas; Birner, Peter; Poetzi, R.; Gangl, Alfred; Oberhuber, Georg

doi:10.1055/s-2003-44593

Cited by 95 publications

(65 citation statements)

References 12 publications

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“…A study by Dejaco et al showed that the accuracy of diagnosing colitis increases from 66% to 92% when segmental biopsies are taken rather than two biopsies throughout the colon. 4 Rectal biopsies are necessary to either conirm or reject rectal involvement and may be additionally helpful in differentiating IBD from other inlammatory lesions.…”

Section: Discussionmentioning

confidence: 99%

Histopathological evaluation of ulcerative colitis in colonoscopic biopsies

Dhakhwa

Hg²,

Acharya³

2016

J Pathol Nep

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Background: Histopathologic evaluation of colonoscopic mucosal biopsy remains one of the earliest modalities of investigation in patients clinically suspected of ulcerative colitis. Pathologists should be aware of classical histomorphological features to avoid misdiagnosis. The aim of the present study was to evaluate histopathologic features as well as to determine possible atypical presentation.Materials and Methods: Forty newly diagnosed cases of ulcerative colitis were included in the study. Colonoscopic biopsies taken from rectum as well as various areas of colon and ileum depending upon clinical extent of involvement were submitted for histopathological evaluation. Diagnosis of ulcerative colitis was made by correlating clinical, endoscopic and histopathologic findings.Results: Out of 47 cases suspected of ulcerative colitis, histopathologic features were consistent with Ulcerative colitis in 40 cases. Almost all cases (97.5%) showed diffuse active colitis. Cryptitis (100%), crypt abscesses (75%) and basal plasmacytosis (85%) along with crypt architectural abnormalities (75%) and goblet cell depletion (70%) were classical histological changes associated with ulcerative colitis in active phase. Atypical presentations noticed were focal active colitis (2.5%), backwash ileitis (2.5%), rectal sparing (2.5%) and skip areas (5%).Conclusion: Accurate diagnosis of ulcerative colitis requires elaborate knowledge of histopathologic features along with awareness of possible atypical presentation.

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Section: Discussionmentioning

confidence: 99%

Histopathological evaluation of ulcerative colitis in colonoscopic biopsies

Dhakhwa

Hg²,

Acharya³

2016

J Pathol Nep

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“…Zurzeit werden keine Spezialverfahren (Immunhistochemie, andere Techniken) für die Routine verwendet [191,192]. Der Nutzen multipler Biopsien aus verschiedenen Regionen des unteren GI-Traktes zur Diagnosesicherung eines M. Crohn ist in der Literatur belegt [168,170,193,194].…”

Section: Postoperative Diagnostikunclassified

Aktualisierte S3-Leitlinie – „Diagnostik und Therapie des Morbus Crohn“ 2014

et al. 2014

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“…This has been demonstrated for inflammatory diseases such as chronic idiopathic inflammatory bowel diseases (IBD) and for neoplastic diseases. [9] Therefore different guidelines for endoscopic sampling in various diseases have been developed. [10][11][12] ECCO guidelines propose to obtain "multiple" biopsies from five sites around the colon (including the rectum) and the ileum for a reliable diagnosis of Crohn's disease.…”

Section: Number Of Samplesmentioning

confidence: 99%

“…A diagnosis of Crohn's disease on endoscopic samples of the colon relies particularly on the analysis of multiple biopsies from different segments of the colon including the ileum. [68] Analysis of multiple biopsies yields a positive diagnosis of Crohn's disease in 64% of the cases compared to 24% for one single rectal biopsy. [64,69] Biopsies of the terminal ileum are mainly useful in patients with inflammatory diarrhoea.…”

Section: Inflammatory Conditionsmentioning

confidence: 99%