Diagnosis and Management of Neuropathic Pain in Spine Diseases

Bielewicz, Joanna; Kamieniak, Maciej; Szymoniuk, Michał; Litak, Jakub; Czyżewski, Wojciech; Kamieniak, Piotr

doi:10.3390/jcm12041380

Cited by 10 publications

(9 citation statements)

References 241 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The incidence rate of post‐spinal surgery wound infection ranges from 0.2% to 16.1%, averaging 3.1% 28 . Postoperative infections can cause difficult‐to‐heal wounds, prolonged hospital stays, increased mortality and endanger patient safety 29 . These complications not only increase the difficulty of nursing but also may necessitate additional surgical treatment, increasing medical costs for both patients and healthcare providers.…”

Section: Discussionmentioning

confidence: 99%

“… 28 Postoperative infections can cause difficult‐to‐heal wounds, prolonged hospital stays, increased mortality and endanger patient safety. 29 These complications not only increase the difficulty of nursing but also may necessitate additional surgical treatment, increasing medical costs for both patients and healthcare providers. Therefore, timely and thorough debridement of orthopaedic surgery wounds with infection is essential, removing necrotic tissue and secretions to effectively control the infection and prevent deterioration, affecting wound healing.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of wound drainage on the wound infection and healing in patients undergoing spinal surgery: A meta‐analysis

Yang,

Bao,

et al. 2024

International Wound Journal

View full text Add to dashboard Cite

A meta‐analysis was conducted to comprehensively evaluate the impact of wound drainage on postoperative wound infection and healing in patients undergoing spinal surgery. Computer searches were performed, from database inception to October 2023, in EMBASE, Google Scholar, Cochrane Library, PubMed, Wanfang and China National Knowledge Infrastructure databases for studies related to the application of wound drainage in spinal surgery. Two researchers independently screened the literature, extracted data and conducted quality assessments. Stata 17.0 software was employed for data analysis. Overall, 11 articles involving 2102 spinal surgery patients were included. The analysis showed that, compared to other treatment methods, the use of wound drainage in spinal surgery patients significantly shortened the wound healing time (standardized mean difference [SMD]: −1.35, 95% confidence intervals [CI]: −1.91 to −0.79, p < 0.001). However, there was no statistical difference in the incidence of wound infection (odds ratio: 1.35, 95% CI: 0.83–2.19, p = 0.226). This study indicates that wound drainage in patients undergoing spinal surgery is effective, can accelerate wound healing and is worth promoting in clinical practice.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of wound drainage on the wound infection and healing in patients undergoing spinal surgery: A meta‐analysis

Yang,

Bao,

et al. 2024

International Wound Journal

View full text Add to dashboard Cite

show abstract

“…4 A tricyclic antidepressant (TCI) is also used for neuroleptic pain. 5 AMX is also used to reduce antibiotic resistance and inhibit mycobacterial infections. 6 AMX is an Ndesmethyl derivative of loxapine with noradrenaline reuptake inhibition, 5-HT receptor antagonism, and dopamine D2 receptor antagonism.…”

Section: ■ Introductionmentioning

confidence: 99%

“…A rapid-acting antidepressant, amoxapine (AMX), is popular over other cyclic antidepressants, as shown in Figure . A tricyclic antidepressant (TCI) is also used for neuroleptic pain . AMX is also used to reduce antibiotic resistance and inhibit mycobacterial infections .…”

Section: Introductionmentioning

confidence: 99%

Amoxapine-Loaded Solid Lipid Nanoparticles with Superior Preclinical Pharmacokinetics for Better Brain Delivery: LC-MS/MS and GC-MS Analysis

Pawar

Gawali

Kulhari

et al. 2023

ACS Chem. Neurosci.

View full text Add to dashboard Cite

The tricyclic antidepressant amoxapine (AMX) has been reported for a rapid onset of action compared to other cyclic antidepressants. It has very low solubility and bioavailability due to first-pass metabolism. Therefore, we planned to develop solid lipid nanoparticles (SLNs) of AMX using a single emulsification method to increase its solubility and bioavailability. HPLC and LC-MS/MS methods were developed further to quantify AMX in the formulation, plasma, and brain tissue samples. The formulation was studied for entrapment efficiency, loading, and in vitro drug release. Particle size and ζ potential analyses, AFM, SEM, TEM, DSC, and XRD were used for further characterization. In vivo oral pharmacokinetic and brain pharmacokinetic studies were performed using Wistar rats. The entrapment and loading efficiencies of AMX in SLNs were 85.8 ± 3.42 and 4.5 ± 0.45%, respectively. The developed formulation had a mean particle size of 151.5 ± 7.02 nm and a polydispersity index of 0.40 ± 0.11. DSC and XRD results indicated that AMX was incorporated into the nanocarrier system in an amorphous form. SEM, TEM, and AFM studies of AMX-SLNs confirmed the particles’ spherical shape and nanoscale size. AMX solubility increased by approx. 2.67 times compared to the pure drug. The developed LC-MS/MS method was successfully applied to the oral and brain pharmacokinetic study of AMX-loaded SLNs in rats. Oral bioavailability was enhanced 1.6 times compared to the pure drug. The peak plasma concentrations of pure AMX and AMX-SLNs were 617.4 ± 137.4 and 1043.5 ± 150.2 (ng/mL), respectively. AMX-SLNs showed more than 5.8 times brain concentration compared to the pure drug. Based on the findings, it appears that utilizing a solid lipid nanoparticle carrier to transport AMX can be a highly effective delivery method with improved pharmacokinetic properties in the brain. This approach may prove valuable for future antidepressant treatment.

show abstract

“…Epidemiological research shows that NPP impacts approximately 7–8% of the global population ( Murnion, 2018 ), but its prevalence varies from region to region, with a high prevalence in China (17.7%) ( Han et al, 2020 ) with a high prevalence in the United States (10–20%) ( Van Hecke et al, 2014 ; Boehnke et al, 2016 ), and an average prevalence in Europe (6.9–8.2%) ( Bouhassira et al, 2008 ). Due to its high incidence, painful nature, long duration, social and economic burden, and ability to damage to the patient’s physical and mental health, NP has attracted significant research interest in the past few decades ( Bielewicz et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Resting-state functional magnetic resonance imaging reveals brain remodeling after Tuina therapy in neuropathic pain model

Guo

Zhang

et al. 2023

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Tuina, a method of traditional Chinese manual manipulation, is an effective alternative therapy for neuropathic pain (NP), but its analgesic mechanism remains unclear. In this study, we used resting-state functional magnetic resonance imaging (R-fMRI) to explore the analgesic mechanism of Tuina in an NP rat model. After undergoing surgery to induce chronic compression of the dorsal root ganglion (CCD), one group of rats underwent Tuina at the ipsilateral BL40 acupoint once a day for 10 min during the 25 days following surgery while another group did not. Behavioral tests were performed at baseline, on the third day following surgery, and once a week for the next 4 weeks. R-fMRI was performed at baseline and 7 days and 28 days following surgery. Behavioral testing revealed that the Tuina group presented a significant response improvement to mechanical and thermal nociception stimuli compared to the untreated group 2 weeks following CCD surgery. Interestingly, rats submitted to Tuina presented higher measures of spontaneous neuronal activity in basal forebrain region, primary somatosensory cortex barrel field, dentate gyrus, secondary somatosensory cortex, striatum, descending corticofugal pathways, and globus pallidum of the left hemisphere 4 weeks after the CCD surgery compared to rats having undergone CCD only. In addition, on the 28th day, the ALFF signals of the left dentate gyrus, left secondary somatosensory cortex, left striatum, and bilateral primary cingulate cortex were significantly increased while those in the right dentate gyrus and bilateral periaqueductal gray were significantly decreased compared to those on the 7th day. Correlation analysis showed that the ALFF values of the left descending corticofugal pathways and globus pallidum had a positive correlation with mechanical withdrawal threshold and paw withdrawal thermal latency tests. Altogether, these results indicate that NPP induced by CCD surgery affects the plasticity of the cerebral cortex, and that Tuina alleviate pain behavior by promoting cortical remodeling.

show abstract

Diagnosis and Management of Neuropathic Pain in Spine Diseases

Cited by 10 publications

References 241 publications

Effect of wound drainage on the wound infection and healing in patients undergoing spinal surgery: A meta‐analysis

Effect of wound drainage on the wound infection and healing in patients undergoing spinal surgery: A meta‐analysis

Amoxapine-Loaded Solid Lipid Nanoparticles with Superior Preclinical Pharmacokinetics for Better Brain Delivery: LC-MS/MS and GC-MS Analysis

Resting-state functional magnetic resonance imaging reveals brain remodeling after Tuina therapy in neuropathic pain model

Contact Info

Product

Resources

About