Diagnosis and treatment of osteopenia

Karagüzel, Gülay; Holick, Michael F.

doi:10.1007/s11154-010-9154-0

Cited by 121 publications

(111 citation statements)

References 77 publications

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“…When implementing the World Health Organization's definitions for osteopenia and osteoporosis [24], bone scan results from baseline reveal that 41% of participants ( n = 7) and 24% ( n = 4) were osteopenic or osteoporotic at the spine, respectively. At the hip, 56% ( n = 10) were osteopenic while another 17% ( n = 3) met the criteria for diagnosis of osteoporosis.…”

Section: Resultsmentioning

confidence: 99%

Combined aerobic and resistance training improves bone health of female cancer survivors

et al. 2016

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IntroductionCancer pathogenesis and resulting treatment may lead to bone loss and poor skeletal health in survivorship. The purpose of this investigation was to evaluate the influence of 26 weeks of combined aerobic and resistance-training (CART) exercise on bone mineral density (BMD) in a multi-racial sample of female cancer survivors.MethodsTwenty-six female cancer survivors volunteered to undergo CART for 1 h/day, 3 days/week, for 26 weeks. The Improving Physical Activity After Cancer Treatment (IMPAACT) Program involves supervised group exercise sessions including 20 min of cardiorespiratory training, 25 min of circuit-style resistance-training, and 15 min of abdominal exercises and stretching. BMD at the spine, hip, and whole body was assessed using dual-energy X-ray absorptiometry (DXA) before and after the intervention. Serum markers of bone metabolism (procollagen-type I N-terminal propeptide, P1NP, and C-terminal telopeptides, CTX) were measured at baseline, 13 weeks, and at study completion.ResultsEighteen participants, with the average age of 63.0 ± 10.3 years, completed the program. Mean duration since completion of cancer treatment was 6.2 ± 10.6 years. Paired t-tests revealed significant improvements in BMD of the spine (0.971 ± 0.218 g/cm2 vs. 0.995 ± 0.218 g/cm2, p = 0.012), hip (0.860 ± 0.184 g/cm2 vs. 0.875 ± 0.191 g/cm2, p = 0.048), and whole body (1.002 ± 0.153 g/cm2 vs. 1.022 ± 0.159 g/cm2, p = 0.002). P1NP declined 22% at 13 weeks and 28% at 26 weeks in comparison to baseline (p < 0.01) while CTX showed a non-significant decrease of 8% and 18% respectively.ConclusionsWe report significant improvements in BMD at the spine, hip, and whole body for female cancer survivors who completed 26 weeks of CART. This investigation demonstrates the possible effectiveness of CART at improving bone health and reducing risk of osteoporosis for women who have completed cancer treatment. The IMPAACT Program appears to be a safe and feasible way for women to improve health after cancer treatment.

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Section: Resultsmentioning

confidence: 99%

Combined aerobic and resistance training improves bone health of female cancer survivors

et al. 2016

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“…The gradual reduction of bone mass with increasing age remains one of the most common features characterizing a range of degenerative skeletal disorders. Due to increased longevity, altered lifestyle and hormonal imbalance, we have witnessed a dramatic increase of osteopenicdriven skeletal diseases such as osteoporosis [1]. Osteoporosis is an extremely widespread disease, representing a major economic burden on health care systems worldwide, with direct costs in the US of $19 billion in 2005 [2] and indirect costs being far greater.…”

Section: Introductionmentioning

confidence: 99%

“…However, while such drugs may halt the progression of bone loss, they do not lead to net accrual of bone in the skeleton. For that reason, potent anabolic drugs, such as parathyroid hormone analogues and strontium salts, have proven to be more therapeutically effective, since they actually improve bone structure and increase bone size [1] and [4]. However, the cost of treatment imposes some limitations on their use, and the discontinuation of an anabolic therapy leads to rapid bone loss [4] and [5].…”

Section: Introductionmentioning

confidence: 99%

Neuropeptide Y Y1 receptor antagonism increases bone mass in mice

Sousa

Baldock

Enriquez

et al. 2012

Bone

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The neuropeptide Y system has emerged as one of the major neural signalling pathways regulating bone homeostasis. Absence of Y1 receptor signalling from bone forming osteoblasts is responsible for an enhancement on bone mass in mice, suggesting that pharmacological blockade of Y1 receptors may offer a novel anabolic treatment option for improving bone mass. Here we show that oral administration of the selective Y1 receptor antagonist BIBO3304 for 8 weeks dose-dependently increases bone mass in mice. Histomorphometric analysis revealed a significant 1.5-fold increase in cancellous bone volume in the femora of mice treated with BIBO3304. Furthermore, bone microarchitecture was improved, with greater trabecular number and trabecular thickness. This increase in bone mass was associated with a significant increase in bone anabolic activity of osteoblasts and, interestingly, was evident despite a coincident increase in bone resorption, as evidenced by an increase in the number of the osteolytic osteoclasts. Changes were also evident in cortical bone, with a significant increase in periosteal mineral apposition rate. Importantly, no adverse extra-skeletal side effects were observed through Y1 receptor antagonism over the 8-week treatment period, with no effects of even the higher BIBO3304 dose on body weight, adiposity, energy metabolism or circulating corticosterone levels. Taken together, this work describes the first NPY-based anabolic treatment for improving bone mass, and highlights the therapeutic potential of blocking Y1 receptor signalling for the prevention of, or recovery from, degenerative skeletal diseases.

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“…Já na osteoporose ocorre redução da massa óssea e deterioração da microarquitetura, a nível de osso cortical e trabecular, o que é ocasionado pelo desequilíbrio apresentado entre reabsorção e aposição. Predomina a atividade osteoclástica sobre a osteoblástica, desencadeando maior reabsorção do que formação e consequentemente perda óssea (KANIS, 1994;KANIS et al, 1994;KARSDAL et al, 2006;KARAGUZEL;HOOLICK, 2010).…”

Section: Osteoporoseunclassified

A Osteoporose na Infância e na Adolescência

Spezzia

2018

Ens Cien C Biol Agra Saúde

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A osteoporose é uma doença osteometabólica caracterizada por perda de massa óssea e deterioração da microarquitetura do tecido ósseo com consequente fragilidade óssea e maior suscetibilidade à fraturas. O acometimento por osteopenia e osteoporose com algumas peculiaridades ocorre também em crianças e em adolescentes. O objetivo deste artigo foi averiguar aspectos clínicos de relevância acerca da osteoporose na infância e na adolescência encontrados na literatura. Foi realizada revisão bibliográfica com levantamento através de expressões de busca nas bases de dados: PubMED, Lilacs. Foram incluídos na pesquisa, trabalhos publicados em periódicos nacionais e internacionais de 2005 a 2015, nos idiomas inglês e português, que tratavam dos aspectos principais que envolvem acometimento de crianças e de adolescentes por osteoporose. Também foram considerados apontamentos de livros, monografias, dissertações e teses que possuíam esse mesmo conteúdo. A densidade mineral óssea nessas faixas etárias está intimamente relacionada com o pico de massa óssea que foi determinado até o final da segunda década de vida. Toda população infantil e de adolescentes, bem como seus pais e/ou responsáveis poderia ser alertada através da conscientização acerca dos problemas que podem ser gerados com essa enfermidade para que assim pudessem prevenir essa doença, uma vez que a mesma é incurável e causa enormes transtornos na vida adulta. Concluiu-se que é imprescindível que se empreendam condutas preventivas com realização de diagnóstico e prognóstico precoces nos acometidos pela osteoporose, visando minimizar danos ou sequelas futuras, podendo dessa forma propiciar melhores condições e qualidade de vida a esses pacientes. Palavras

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Diagnosis and treatment of osteopenia

Cited by 121 publications

References 77 publications

Combined aerobic and resistance training improves bone health of female cancer survivors

Combined aerobic and resistance training improves bone health of female cancer survivors

Neuropeptide Y Y1 receptor antagonism increases bone mass in mice

A Osteoporose na Infância e na Adolescência

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