Diagnosis of asymptomatic metastatic lobular carcinoma of breast on conventional and liquid‐based cervical cytology samples from the same patient

Abstract

Fujiwara M. Cutaneous sclerosing perineurioma of the digit. Int J Dermatol 2006;45:1086-8. 5. Housini I, Dabbs DJ. Fine needle aspiration cytology of perineurioma: report of a case with histologic, immunohistochemical and ultrastructural studies. Acta Cytol 1990;34:420-4. 6. Akerman M, Domanski HA. The cytological features of soft tissue tumors in fine needle aspiration smears classified according to histotype.

Metastatic breast carcinoma presenting in the uterine cervix: Lessons learned from liquid‐based Pap test

“…Among these features, single cell filing was mentioned in almost all reports, 3,4,9,10,16,18 but “cell‐in‐cell” arrangement was not described in any of the reported cases. Many cytology reports described distinctive signet ring cell or intracytoplasmic mucin vacuole, which was not seen in our case 3,4,6,7,9,10,16,18 …”

“…There are many case reports of metastatic breast cancer identified in the uterine cervix, 1‐18 but only a few focus on its cytologic features in liquid‐based Pap tests 6,9 . Most cytology reports are older and on conventional Pap smears 1,3,4,7,10,13,16,18 .…”

“…In the last decade, liquid‐based Pap test has largely replaced the conventional Pap smear. While liquid‐based Pap test offers several advantages over conventional smears such as clean background and improved cytomorphology due to monolayer preparation, 6 it may also make recognition of rare findings more challenging as a newer technique. It is important to recognize and distinguish metastatic breast carcinoma from primary cervical malignancies.…”

Liquid-Based Cytology in Fine-Needle Aspiration of Breast Lesions: A Review

“…Biscotti et al [14] illustrated a TP sample of a lobular carcinoma showing dyshesive cells with eccentric nuclei and well-preserved nuclear detail in a clean background. More recently, Crossley et al [25] reported the case of a patient with a lobular carcinoma of the breast metastatic to the cervix. After treatment with chemotherapy for her breast tumor, a cervical sample was obtained and was prepared by the SP method, displaying cells with high nuclear-cytoplasmic ratio, hyperchromasia and intracytoplasmic lumina that were consistent with a diagnosis of metastatic lobular carcinoma.…”