Diagnosis of kidney damage using novel acute kidney injury biomarkers: assessment of kidney function alone is insufficient

Abstract

Acute kidney injury (AKI) is a syndrome that is associated with a major burden of morbidity and mortality in a variety of high risk patient populations, many of them cared for by intensivists. Following renal transplantation, delayed graft function (DGF) caused by severe acute tubular necrosis (ATN), defined by a requirement for dialysis during the initial post-transplant week, complicates postoperative management, and if prolonged (>14 days), adversely affects allograft survival. Neutrophil gelatinase-associated lipocalin (NGAL) and other novel biomarkers can detect AKI earlier than serum creatinine, and can predict AKI severity in high risk patient populations, including kidney transplant recipients. Hollmen and colleagues now demonstrate that elevated urine NGAL in deceased kidney donors is a significant risk factor for prolonged post-transplant DGF in recipients. These findings have clear implications with regard to potentially improved assessment of deceased donor suitability for potential renal allograft donation. These findings are also consistent with the growing evidence that severe ATN diagnosed by markedly elevated levels of AKI biomarkers is a useful predictor of the requirement for acute renal replacement therapy in AKI patients.

Medición del NGAL urinario en el donante para detectar función retardada del injerto renal en el receptor

“…Una de las moléculas más estudiada es el NGAL, proteína de 25 kd que se produce en los neutrófilos y en las células tubulares renales luego de la lesión de isquemia reperfusión (14,28,29). Estudios previos han sugerido que el NGALu se produce específicamente en los riñones por lo cual valores altos son sugestivos de lesión renal aguda (3,30-32).…”