Diagnosis of Protein-Losing Enteropathy by Gastrointestinal Clearance of Alpha1-Antitrypsin

Bernier, J J; Desmazures, C; Florent, C.; Aymes, C; L'Hirondel, Ch.

doi:10.1016/s0140-6736(78)92650-8

Cited by 109 publications

(53 citation statements)

References 2 publications

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“…Studies using radiolabelled proteins have demonstrated that there is faecal protein loss in patients with active Crohn's disease and it may therefore be a useful marker of disease activity. Other studies have shown faecal α1 antitrypsin clearance to be a useful indicator of protein losing enteropathy [35] and that in patients with inflammatory bowel disease, 72 hour faecal clearance of α1 antitrypsin is a useful method for quantitating intestinal protein loss [36,37] . Faecal clearance of α1 antitrypsin correlates with that of 51 Cr-albumin, and moderate rectal bleeding does not affect the α1 antitrypsin determination [36] .…”

Section: Faecal Markersmentioning

confidence: 99%

Non-invasive investigation of inflammatory bowel disease

Tibble

Bjarnason

2001

WJG

139

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Section: Faecal Markersmentioning

confidence: 99%

Non-invasive investigation of inflammatory bowel disease

Tibble

Bjarnason

2001

WJG

139

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“…A simpler, but possibly less reliable approach is to measure the clearance of faecal alpha l-antitrypsin, a protein which is not degraded by proteolytic enzymes within the gut. 30 Burns may produce substantial albumin loss from the skin exudate. In addition, shifts in distribution due to fluid loss and changes in vascular permeability and acute phase suppression of synthesis may result from accompanying infection and inflammation.…”

Section: Serum Albumin Concentration As a Means Of Assessing Exogenoumentioning

confidence: 99%

When is Serum Albumin Worth Measuring?

Whicher

Spence

1987

Ann Clin Biochem

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This paper critically examines the usefulness of serum albumin measurement in the light of current laboratory practice and knowledge of the pathophysiology of albumin metabolism. The main conclusions and recommendations are as follows: Albumin measurement forms a limited, but useful part of the investigation of liver disease; a normal serum albumin concentration makes the diagnosis of cirrhosis unlikely, while a low level in viral hepatitis suggests either severe hepatocellular damage or other complications. Albumin measurement is essential in selecting patients for, and in determining the amount and frequency of, albumin replacement. Serum albumin concentration provides a useful indication of prognosis in myeloma. In the long-term management of patients undergoing enteral or parenteral nutrition, serum albumin concentration is one of several parameters which, together, are useful in predicting the outcome of treatment. (v) The serum albumin concentration may provide a clue to the aetiology of unexplained oedema. Serum albumin measurement is useful in indicating the level of ionised calcium and of unbound unconjugated bilirubin.

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“…The intestinal clearance of oti-antiproteinase ("ocrantitrypsin") has been suggested as a marker of intestinal protein loss during inflammatory bowel diseases such as Crohrfs disease and ulcerative colitis (1,2). However, the use of this quantity in the assessment of inflammatory bowel disease activity remains controversial (3,4).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Intestinal Clearance and Faecal Excretion of α1-Antiproteinase and Immunoglobulins During Crohn’s Disease and Ulcerative Colitis

Kapel¹,

Meillet²,

Favennec³

et al. 1992

Clinical Chemistry and Laboratory Medicine

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Summary:The intestinal clearance of oc r antiproteinase, monomeric IgA and IgG, and the daily fecal output of polymeric IgA and IgM were investigated in patients with inflammatory bowel diseases (inactive and active Crohn's disease, ulcerative colitis) and in a control group. The intestinal clearance of a r antiproteinase was significantly increased in all patients with inflammatory bowel diseases (p < 0.01), irrespective of the grade of the disease. In contrast, increases in intestinal clearances of monomeric IgA and IgG were more closely related to the severity of the intestinal lesions. The associate determination of these three quantities should therefore be of interest for monitoring the degree of intestinal bowel inflammation. Faecal output of polymeric IgA was significantly increased in active intestinal disease (p < 0.01), whereas faecal IgM levels were not. The determination of the faecal output of polymeric IgA should contribute to the assessment of the activity of inflammatory bowel diseases, and may provide insight into the activation of the mucosal immune system.

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Diagnosis of Protein-Losing Enteropathy by Gastrointestinal Clearance of Alpha1-Antitrypsin

Cited by 109 publications

References 2 publications

Non-invasive investigation of inflammatory bowel disease

Non-invasive investigation of inflammatory bowel disease

When is Serum Albumin Worth Measuring?

Evaluation of Intestinal Clearance and Faecal Excretion of α1-Antiproteinase and Immunoglobulins During Crohn’s Disease and Ulcerative Colitis

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