Diagnostic Accuracy of PremaQuick versus Actim Partus in Prediction of Preterm Labor in Symptomatic Women within 14 Days

Abu-Faza, Mohannad; Abdelazim, Ibrahim A.; Svetlana, Shikanova; Farag, Rania H.; Nair, Sreelatha R.

doi:10.4236/ojog.2018.88078

Cited by 7 publications

(15 citation statements)

References 28 publications

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“…Premaquick performed well among women with threatened preterm labor, predicting delivery within 14 days of enrollment with high sensitivity, specificity, PPV, NPV, and accuracy. This finding corroborates a previous Nigerian study on Premaquick by Eleje et al., and is consistent with a study in Kuwait by Abu‐Faza et al., who noted high specificity and PPV with Premaquick but relatively low sensitivity (39.8%), NPV (62.2%), and accuracy (68.2%). The low sensitivity, NPV, and accuracy observed by Abu‐Faza et al .…”

Section: Discussionsupporting

confidence: 92%

“…This finding corroborates a previous Nigerian study on Premaquick by Eleje et al., and is consistent with a study in Kuwait by Abu‐Faza et al., who noted high specificity and PPV with Premaquick but relatively low sensitivity (39.8%), NPV (62.2%), and accuracy (68.2%). The low sensitivity, NPV, and accuracy observed by Abu‐Faza et al . might be due to the relatively small sample size of 110 women.…”

Section: Discussionsupporting

confidence: 92%

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Combined insulin‐like growth factor binding protein‐1/interleukin‐6 (Premaquick) versus fetal fibronectin for predicting preterm delivery among women with preterm contractions

Asiegbu

Eleje

Ibeneme

et al. 2020

Intl J Gynecology & Obste

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Objectives:To compare accuracy between Premaquick (combined test for native insulin-like growth factor binding protein-1 (IGFBP-1), total IGFBP-1, and interleukin-6) and fetal fibronectin (Ffn) in predicting preterm delivery. Methods:Prospective study among women at 28-36 +6 gestational weeks with threatened preterm labor attending Federal Medical Center, Owerri, Nigeria, from August 2017 to February 2019. Cervico-vaginal fluids were collected and tested by Premaquick and Ffn tests. The women were followed for 14 days. Sensitivity, specificity, and negative (NPV) and positive (PPV) predictive value for delivery were compared between the tests.Results: Among 213 women assessed for eligibility, 183 were enrolled and 175 completed the study. The sensitivity, specificity, PPV, NPV, and accuracy of the Premaquick versus Ffn tests were, respectively, 96.3% versus 51.9%, 97.6% versus 98.4%, 89.7% versus 87.5%, 99.2% versus 90.3% and 97.3% versus 90.0% for preterm delivery within 14 days. Ffn had higher specificity (98.5% vs 97.8%; P>0.99), but Premaquick had higher PPV (92.7% vs 90.9%; P>0.99). Conclusion:Both tests seem to have high utility in predicting preterm delivery, but Premaquick showed higher accuracy in terms of sensitivity and PPV. Premaquick might be a feasible alternative to Ffn for predicting preterm delivery among symptomatic women in a low-income setting.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Combined insulin‐like growth factor binding protein‐1/interleukin‐6 (Premaquick) versus fetal fibronectin for predicting preterm delivery among women with preterm contractions

Asiegbu

Eleje

Ibeneme

et al. 2020

Intl J Gynecology & Obste

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“…[ 3 ] The PTL was diagnosed by regular uterine contractions lasting at least 30 s and occurring at least four times per 30 min with significant cervical changes on digital examination (cervical dilatation <3 cm, cervical effacement ≤50%). [ 4 ]…”

Section: Case Reportsmentioning

confidence: 99%

Cesarean section scar dehiscence during pregnancy: Case reports

Abdelazim¹,

Shikanova

Kanshaiym

et al. 2018

J Family Med Prim Care

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Background:The incidence of cesarean section increased worldwide with subsequent increase in the risk of cesarean section scar dehiscence (CSSD). The clinical significance and the management of the CSSD are still unclear.Case Reports:Here, we report two cases of CSSD. A 35-year-old woman, gravida 2, previous CS, due to preterm premature rupture of membranes (PPROM) and breech presentation at 30 weeks, was admitted for elective CS at 38+3d weeks’ gestation. During the second elective CS, it was seen that the site of the previous CS scar was very thin along its whole length and the anterior uterine wall was completely deficient, leaving visible bulging fetal membranes and moving baby underneath. A 32-year-old woman, previous three CSs, was admitted as unbooked case without any antenatal records at 29+4d weeks’ gestation, triplet pregnancy with preterm labor. She received betamethasone and magnesium sulfate (MgSO4) for fetal lung and fetal brain protection, respectively, followed by emergency CS. During the CS, the previous CSs scars were dehiscent over more than half of its length and the anterior uterine wall was missing leaving visible fetal membranes. The uterine incision of the studied women was repaired in two layers using vicryl 0 interrupted simple stitches for the first layer, followed by interrupted mattress stitches for the second layer. The studied women had uneventful postoperative recovery and were discharged from the hospital after counseling regarding intraoperative findings, uterine incisions repair, and future pregnancies.Conclusion:It is useful to assess the lower uterine segment of women with previous CS using the available ultrasound facilities. If the CSSD is diagnosed before the elective CS, the surgeon should prepare himself with the safest uterine incision with least possible complications and the best way of repair of the defective or dehiscent uterine wall.

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“…The IGFBP-1 released into the cervico-vaginal fluid (CVF) during the process of chorio-decidual disruption of PTL [13][14][15]. The IGFBP-1 is a good negative predictor of PTL [16].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of PremaQuick in detection of preterm labor in symptomatic women

Abdelazim

Karimova²,

Shikanova

2022

Ginekol Pol

Self Cite

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Objectives: Failure to identify women at risk of preterm labor (PTL) leads to failure to implement standard measures. This study designed to evaluate the accuracy of PremaQuick test in detection of PTL in women presented with threatened preterm labor (TPTL). Material and methods:One hundred and twenty-two (122) pregnant women, singleton pregnancy, < 37 weeks, admitted with TPTL included in this study, and were compared to 122 controls.After thorough evaluation, participants were examined using sterile vaginal speculum for cervico-vaginal fluid (CVF) sampling, and PremaQuick test. The CVF sampling was followed by trans-vaginal sonographic (TVS) assessment of cervical length (CL). Participants were managed according to hospitals policy thorough their admission, and after discharge in the ante-natal clinics till delivery. After delivery, the delivery data were compared by the recorded participants` data on admission. Results:The PremaQuick test had 95.1% sensitivity, 97.5% specificity, 97.5% positive predictive value, 95.2% negative predictive value, and 96.3% accuracy in detection of PTL.The PremaQuick had significantly higher true negative rate, specificity, positive predictive 2 value, and overall accuracy in detection of PTL compared to CL < 25 mm (p = 0.005, 0.005, 0.01, 0.002; respectively). Conclusions:The PremaQuick is an accurate bedside test in detection of PTL in women presented with TPTL. It had 95.1% sensitivity, 97.5% specificity, 97.5% positive predictive value, 95.2% negative predictive value, and 96.3% overall accuracy in detection of PTL. The PremaQuick had significantly higher true negative rate, specificity, positive predictive value, and overall accuracy in detection of PTL compared to CL < 25 mm.

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Diagnostic Accuracy of PremaQuick versus Actim Partus in Prediction of Preterm Labor in Symptomatic Women within 14 Days

Cited by 7 publications

References 28 publications

Combined insulin‐like growth factor binding protein‐1/interleukin‐6 (Premaquick) versus fetal fibronectin for predicting preterm delivery among women with preterm contractions

Combined insulin‐like growth factor binding protein‐1/interleukin‐6 (Premaquick) versus fetal fibronectin for predicting preterm delivery among women with preterm contractions

Cesarean section scar dehiscence during pregnancy: Case reports

Diagnostic accuracy of PremaQuick in detection of preterm labor in symptomatic women

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