Diagnostic accuracy, reproducibility and robustness of fibrosis blood tests in chronic hepatitis C: A meta-analysis with individual data

Comparison of nine blood tests and transient elastography for liver fibrosis in chronic hepatitis C: The ANRS HCEP-23 study

“…The AUROCs of each test were comparable to those reported in the original publications [6][7][8][9][10][11][12][13][14][15]18,20] when expressed using observed-AUROCs according to the prevalence of stages defining advanced and non-advanced fibrosis. We observed similar AUROCs to those reported in meta-analyses [34][35][36] for the most validated biomarkers, Fibrotest Ò , Fibrometer Ò , and Apri and without major differences with interpretable Fibroscan™, Hepascore Ò , and ELFG. In diagnosing cirrhosis, the ''Fibrostic'' study [37] showed a significantly better performance of Fibroscan™ compared to serum markers while in contrast, our study shows that all the tests performed equivalently.…”

Comparison of liver fibrosis blood tests developed for HCV with new specific tests in HIV/HCV co-infection

“…-the comparison of this specific test to previous blood tests, called here HCV fibrosis tests, either simple or sophisticated as distinguished in the previous large comparative study [14]; -the best overall diagnostic performance by calculating the diagnostic cut-off values of HCV fibrosis tests adapted for the diagnosis of significant liver fibrosis in this HIV/HCV population [10,19]; -the single performance of blood tests for each fibrosis stage [22], which allows for the circumvention of prevalence bias, by calculating the rates of correct classification of the blood tests (especially worthwhile in patients with no fibrosis or with cirrhosis); -the individual performance (the most useful for the clinician) by calculating:…”

“…The overall test reproducibility was evaluated through the change in classification rate between the derivation and validation populations [19]. FibroMeter provided the most reproducible diagnostic performance, followed by FibroMeter HICV.…”

“…Automation and assay techniques varied between the centers (details not provided), with the exceptions of apolipoprotein A1 and a-2-macroglobulin (Dade Behring) and hyaluronic acid (Corgenix). Original blood tests were calculated according to the most recent published formulas [5,[17][18][19] or patent for Fibrotest (WO 02/16949). The list of variables included in each test is detailed in the Appendix.…”

Developing a ‘traffic light’ test with potential for rational early diagnosis of liver fibrosis and cirrhosis in the community

“…5 Alongside this project, a number of competing and perhaps equally effective non-invasive diagnostic methodologies have been published. [6][7][8][9][10] This traffic light system is probably no more accurate than the better ones, but it was developed specifically for use in primary care, with the aim of being intuitively easy for patients to understand.…”