Diagnostic and predictive values of procalcitonin in bloodstream infections for nosocomial pneumonia

Shi, Yan; Sun, Li; Li, Rui; Tao, Yong; Zhang, Hong Bo; Zhang, Guoqiang

doi:10.1016/j.jcrc.2017.12.022

Cited by 11 publications

(2 citation statements)

References 35 publications

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“…Our data confirmed the previous observations about the role of PCT and CRP in predicting BC results in critically ill patients [ 4 , 5 ]. Of interest, CRP was not able to predict BC results, whereas PCT values correlated with GN bacteremia and, among them, specifically identified Enterobacteriaceae.…”

supporting

confidence: 92%

Comparison between procalcitonin and C-reactive protein to predict blood culture results in ICU patients

et al. 2018

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supporting

confidence: 92%

Comparison between procalcitonin and C-reactive protein to predict blood culture results in ICU patients

et al. 2018

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“…PCT is a widely accepted and useful biomarker for invasive bacterial infection in children. Its use has been extended to monitor sepsis [24,25], respiratory tract infections [26], bronchiolitis [27], hospital-acquired infections [28], and also patients after cardiac surgery [29]. A value over 2 ng/mL within the first 24 hours of cardiac surgery with cardiopulmonary bypass…”

Section: Discussionmentioning

confidence: 99%

Infection…what else? The usefulness of procalcitonin in children after cardiac surgery

et al. 2021

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Objectives Procalcitonin is a useful biomarker for predicting bacterial infection after cardiac surgery. However, sometimes procalcitonin rises following cardiac surgery without a confirmation of bacterial infection. The aim was to analyse procalcitonin levels in children without a bacterial infection after cardiac surgery. Study design This is a prospective, observational study of children <18 years old admitted to the pediatric intensive care unit after cardiac surgery. Results 1,042 children were included, 996 (95.6%) without a bacterial infection. From them, severe complications occurred in 132 patients (13.3%). Procalcitonin increased differentially depending on the type of complication. Patients who presented a poor outcome (n = 26, 2.6%) had higher procalcitonin values in the postoperative period than the rest of patients (<24 hours: 5.8 ng/mL vs. 0.6 ng/mL; 24–48 hours, 5.1 ng/mL vs. 0.8 ng/mL, and 48–72 hours, 5.3 ng/mL vs. 1.2 ng/mL), but these values remained stable over time (p = 0.732; p = 0.110). The AUC for procalcitonin for predicting poor outcome was 0.876 in the first 24 hours. The cut-off point to predict poor outcome was 2 ng/mL in the first 24 hours (sensitivity 86.9%, specificity 77.3%). Patients with bacterial infection (n = 46) presented higher values of procalcitonin initially, but they decreased in the 48–72 hours period (<24 hours: 4.9 ng/mL; 24–48 hours, 5.8 ng/mL, and 48–72 hours, 4.5 ng/mL). Conclusions A procalcitonin value<2 ng/mL may indicate the absence of infection and poor outcome after cardiac surgery. The evolution of the values of this biomarker might help to discern between infection (where procalcitonin will decrease) and poor outcome (where procalcitonin will not decrease).

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Clinical and microbiological characteristics of patients with bacteremia and normal procalcitonin

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et al. 2021

Diagnostic Microbiology and Infectious Disease

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Diagnostic and predictive values of procalcitonin in bloodstream infections for nosocomial pneumonia

Abstract: PCT could differentiate between GN and GP bloodstream infections in patients with NP. However, PCT levels were less predictive of mortality compared with the PSI.

Cited by 11 publications

References 35 publications

Comparison between procalcitonin and C-reactive protein to predict blood culture results in ICU patients

Comparison between procalcitonin and C-reactive protein to predict blood culture results in ICU patients

Infection…what else? The usefulness of procalcitonin in children after cardiac surgery

Clinical and microbiological characteristics of patients with bacteremia and normal procalcitonin

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