Diagnostic and prognostic predictive values of circulating sTREM-1 in sepsis: A meta-analysis

Qin, Qin; Liang, Li; Xia, Yiqin

doi:10.1016/j.meegid.2021.105074

Cited by 18 publications

(12 citation statements)

References 34 publications

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“…After the body is infected, TREM‐1 falls off as the expression increases on the surface of activated neutrophils or macrophages, 26 so sTREM‐1 can be detected in body fluids. During the infection process, sTREM‐1 can be released into body fluids and is closely related to the severity of the infection, especially in patients with sepsis and bronchial bubble lavage fluid of patients with pneumonia, sTREM‐1 is significantly increased 30 . In this study, we found that the serum sTREM‐1 level of neonatal sepsis was significantly higher than that of the control group.…”

Section: Discussionmentioning

confidence: 49%

“…[21][22][23] In this study, we found that the serum 25(OH)D level of patients with sepsis was significantly lower than that of the control group, and the VDR rs739837 G > T allelic variation was correlated with the increase of serum 25(OH)D. Küchler et al 24 with sepsis and bronchial bubble lavage fluid of patients with pneumonia, sTREM-1 is significantly increased. 30 In this study, we found that the serum sTREM-1 level of neonatal sepsis was significantly higher than that of the control group. TREM-1 rs2234246 locus C > T allelic variants were associated with increased serum sTREM-1 levels.…”

Section: Discussionmentioning

confidence: 49%

“…During the infection process, sTREM‐1 can be released into body fluids and is closely related to the severity of the infection, especially in patients with sepsis and bronchial bubble lavage fluid of patients with pneumonia, sTREM‐1 is significantly increased. 30 In this study, we found that the serum sTREM‐1 level of neonatal sepsis was significantly higher than that of the control group. TREM ‐ 1 rs2234246 locus C > T allelic variants were associated with increased serum sTREM‐1 levels.…”

Section: Discussionmentioning

confidence: 53%

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The relationship between vitamin D receptor gene and TREM‐1 gene polymorphisms and the susceptibility and prognosis of neonatal sepsis

Que

et al. 2022

Clinical Laboratory Analysis

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Neonatal sepsis is the main cause of death of newborns, especially premature infants. According to the statistics of epidemiology, the incidence rate of full-term infants is about 1%, the incidence rate of very low birth weight infants is as high as 20%, the mortality rate of early-onset sepsis is 13%, and the mortality rate of late-onset sepsis is 8.9%, which is extremely low, the mortality rate of very low birth weight infants can reach more than 20%. [1][2][3] In recent years, with the completion of the Human Genome Project and the development of

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Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 53%

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The relationship between vitamin D receptor gene and TREM‐1 gene polymorphisms and the susceptibility and prognosis of neonatal sepsis

Que

et al. 2022

Clinical Laboratory Analysis

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“…Described as a marker of inflammation in sepsis, sTREM-1 has been largely studied as a diagnostic marker of infection, in blood or bronchoalveolar lavage (28, 29, 36). In addition, its association with mortality was repeatedly investigated, and elevated sTREM-1 concentrations at ICU admission were associated with higher mortality in sepsis (30–33, 36, 37). We confirmed these results in the current study as we observed that nonsurvivors presented with higher sTREM-1 levels at D1/D2 than survivors.…”

Section: Discussionmentioning

confidence: 99%

Persistently Elevated Soluble Triggering Receptor Expressed on Myeloid Cells 1 and Decreased Monocyte Human Leucocyte Antigen DR Expression Are Associated With Nosocomial Infections in Septic Shock Patients

Venet

Bidar

Derive³

et al. 2023

Critical Care Explorations

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Sepsis-acquired immunosuppression may play a major role in patients' prognosis through increased risk of secondary infections. Triggering receptor expressed on myeloid cells 1 (TREM-1) is an innate immune receptor involved in cellular activation. Its soluble form (sTREM-1) has been described as a robust marker of mortality in sepsis. The objective of this study was to evaluate its association with the occurrence of nosocomial infections alone or in combination with human leucocyte antigen-DR on monocytes (mHLA-DR).DESIGN: Observational study. SETTING: University Hospital in France.PATIENTS: One hundred sixteen adult septic shock patients as a post hoc study from the IMMUNOSEPSIS cohort (NCT04067674). INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS:Plasma sTREM-1 and monocyte HLA-DR were measured at day 1 or 2 (D1/D2), D3/D4, and D6/D8 after admission. Associations with nosocomial infection were evaluated through multivariable analyses. At D6/D8, both markers were combined, and association with increased risk of nosocomial infection was evaluated in the subgroup of patients with most deregulated markers in a multivariable analysis with death as a competing risk. Significantly decreased mHLA-DR at D6/D8 and increased sTREM-1 concentrations were measured at all time points in nonsurvivors compared with survivors. Decreased mHLA-DR at D6/D8 was significantly associated with increased risk of secondary infections after adjustment for clinical parameters with a subdistribution hazard ratio of 3.61 (95% CI, 1.39-9.34; p = 0.008). At D6/D8, patients with persistently high sTREM-1 and decreased mHLA-DR presented with a significantly increased risk of infection (60%) compared with other patients (15.7%). This association remained significant in the multivariable model (subdistribution hazard ratio [95% CI], 4.65 [1.98-10.9]; p < 0.001). CONCLUSIONS:In addition to its prognostic interest on mortality, sTREM-1, when combined with mHLA-DR, may help to better identify immunosuppressed patients at risk of nosocomial infections.

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“…During bacterial and fungal infections, TREM-1 is upregulated, which causes release of sTREM-1. In a 2021 meta-analysis, sTREM-1 was described as having a sensitivity of 0.85 (95% CI 0.76–0.91) and a specificity of 0.79 (95% CI 0.70–0.86) for differentiating sepsis from SIRS among critically ill patients from various countries worldwide [ 27 ]. sTREM-1 was also able to predict 28-day mortality with a sensitivity of 0.80 (95% CI 0.66–0.89) and a specificity of 0.75 95% (CI 0.70–0.86) [ 27 ].…”

Section: Strem-1mentioning

confidence: 99%

Host Response Biomarkers for Sepsis in the Emergency Room

2023

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Diagnostic and prognostic predictive values of circulating sTREM-1 in sepsis: A meta-analysis

Cited by 18 publications

References 34 publications

The relationship between vitamin D receptor gene and TREM‐1 gene polymorphisms and the susceptibility and prognosis of neonatal sepsis

The relationship between vitamin D receptor gene and TREM‐1 gene polymorphisms and the susceptibility and prognosis of neonatal sepsis

Persistently Elevated Soluble Triggering Receptor Expressed on Myeloid Cells 1 and Decreased Monocyte Human Leucocyte Antigen DR Expression Are Associated With Nosocomial Infections in Septic Shock Patients

Host Response Biomarkers for Sepsis in the Emergency Room

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