Diagnostic and prognostic value of neutrophil gelatinase-associated lipocalin, matrix metalloproteinase-9, and tissue inhibitor of matrix metalloproteinases-1 for sepsis in the Emergency Department: an observational study

Wang, Miaomiao; Zhang, Qian; Zhao, Xin; Dong, Guijuan; Li, Chunsheng

doi:10.1186/s13054-014-0634-6

Cited by 68 publications

(79 citation statements)

References 34 publications

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“…Previous experimental (Maitra et al 2010;Teng et al 2012) and clinical studies also report higher levels of TIMP-1 in sepsis (Lauhio et al 2011;Muhl et al 2011;Yazdan-Ashoori et al 2011;Lorente et al 2014) and SA-AKI .…”

Section: Discussionmentioning

confidence: 80%

“…We also found that the septic patients without SA-AKI had higher levels of MMP-9 compared to the control group which indicates that sepsis not complicated by SA-AKI, causes the increase in MMP-9 activity. In sepsis, both higher (Lauhio et al 2011;Muhl et al 2011;YazdanAshoori et al 2011;Wang et al 2014) and lower ) levels of MMP-9 were found but none of these studies reported incidence of SA-AKI in the study population.…”

Section: Discussionmentioning

confidence: 88%

“…We also introduced a unique control group consisting of patients without sepsis or AKI who match the septic patients by age, gender, comorbidities and a type of surgery. The previous studies on MMP-9 and TIMP-1 levels in sepsis compared septic patients to either healthy individuals (Lauhio et al 2011;Muhl et al 2011;Yazdan-Ashoori et al 2011;Wang et al 2014) or other critically ill patients or they compared different subgroups of septic patients (Lorente et al 2014) not taking into account any possible effects of surgery-induced inflammation (Helmersson-Karlqvist et al 2012;Lindholm et al 2015) or comorbidities on MMP-9 and TIMP-1 levels. Comorbidities present in patients with sepsis could alter levels of MMP-9 and TIMP-1 (Vandooren et al 2013;Galliera et al 2015) and are also considered as independent risk factors for AKI in the perioperative period (Kheterpal et al 2009).…”

Section: Discussionmentioning

confidence: 99%

“…The activity of the MMP-9 is closely regulated on multiple levels including the inhibition by regulatory proteins, such as tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) (Galliera et al 2015). Surgery-induced inflammation (Helmersson-Karlqvist et al 2012;Lindholm et al 2015) and sepsis (Muhl et al 2011;Lauhio et al 2011;Yazdan-Ashoori et al 2011;Lorente et al 2014;Wang et al 2014) are associated with altered levels of MMP-9 and TIMP-1. Increased MMP-9 and TIMP-1 expression has also been reported in a variety of AKI animal model studies (Maitra et al 2010;Teng et al 2012) but only one clinical study evaluated MMP-9 as diagnostic biomarker of AKI and not SA-AKI per se (Han et al 2008).…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic Value of Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis-Associated Acute Kidney Injury

Bojić

Kotur‐Stevuljević

Kalezić

et al. 2015

Tohoku J. Exp. Med.

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Sepsis-associated acute kidney injury (SA-AKI) severely impacts morbidity and mortality in surgical patients with sepsis. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) have an important role in pathophysiology of sepsis but they have been unexplored in SA-AKI. We aimed to investigate the role of MMP-9 and TIMP-1 in septic surgical patients with SA-AKI and to evaluate them as diagnostic biomarkers of SA-AKI. This prospective observational study compared 53 major abdominal surgery patients with sepsis divided into SA-AKI (n = 37) and non-SA-AKI (n =16) group to 50 controls without sepsis matched by age, gender, comorbidities and type of surgery. Blood and urine samples from septic patients were collected on admission to ICU and 24, 48, 72 and 96 h later and once from the controls. The levels of MMP-9, TIMP-1, neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1, urea and creatinine were measured. MMP-9/TIMP-1 ratio and disease severity scores, such as Sequential Organ Failure Assessment (SOFA), were calculated. Septic patients with SA-AKI had higher serum TIMP-1 levels and lower serum MMP-9 levels and lower MMP-9/TIMP ratio, compared to septic patients without SA-AKI and controls. The levels of these biomarkers did not change significantly over time. MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio correlated with urea, creatinine, NGAL, and SOFA scores. Moreover, using the area under ROC curve, we showed that TIMP-1 and MMP-9/TIMP-1 ratio, but not MMP-9, were good diagnostic biomarkers of SA-AKI. We report for the first time the potential diagnostic value of TIMP-1 and MMP-9/TIMP-1 ratio in SA-AKI.Keywords: acute kidney injury; biomarker; matrix metalloproteinase-9; sepsis; tissue inhibitor of matrix metalloproteinase-1 Tohoku

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Diagnostic Value of Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis-Associated Acute Kidney Injury

Bojić

Kotur‐Stevuljević

Kalezić

et al. 2015

Tohoku J. Exp. Med.

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“…This review examines the current knowledge about the physiological function of NGAL in glycolipid metabolism and inflammation, which highlights the current understanding of the possible mechanisms underlying the association between glycolipid NGAL also known as 24p3, lipocalin 2 (LCN2), is a 25-kDa secretory glycoprotein that belongs to the lipocalin superfamily, which was initially purified from neutrophil granules. 5,6 Homologous proteins have been identified in mouse (24p3/uterocalin) and rat (alpha 2-microglobulinrelated protein/neu-related lipocalin). Like the other members of the lipocalin superfamily, structural data have confirmed that it shares a barrel shaped tertiary structure with an eight-stranded beta-barrel, which can bind to and transport small lipophilic substances and other hydrophobic molecules, such as prostaglandins, retinoids, hormones and fatty acids.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil gelatinase-associated lipocalin as a potential therapeutic integrator of glycolipid metabolic and inflammatory signaling

Gong¹,

Zhu²,

Gong³

et al. 2017

Int Surg J

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Metabolic syndrome constitutes a group of metabolic conditions that increase the risk of developing diseases, including cardiovascular disease (CVD), non-alcoholic fatty liver disease (NAFLD), obesity and type 2 diabetes mellitus (T2DM) etc. Subclinical inflammation is a candidate etiological factor in the pathogenesis of metabolic syndrome and in the progression of related diseases. Although studies have revealed that subclinical inflammation was activated by intermediary products of basic metabolic processes, the cellular and molecular mechanisms in this association remain largely uncharacterized. Recently, increasing evidence suggests that neutrophil gelatinase-associated lipocalin (NGAL) not only plays a significant role in the glycolipid metabolism, but also modulates immune and inflammatory responses in macrophages. Taking together the ability of NGAL in metabolic and inflammatory signaling, these data suggest that NGAL may be a potential therapeutic target for metabolic and inflammatory signaling for intervention in human glycolipid metabolic disease. This review focuses on current knowledge of the integrators role of NGAL in both glucose and lipid metabolism and inflammatory signaling and discusses the potential therapeutic target in the treatment of glycolipid metabolic-related disease.

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Endothelial dysfunction is an early indicator of sepsis and neutrophil degranulation of septic shock in surgical patients

et al. 2020

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Background: Stratification of the severity of infection is currently based on the Sequential Organ Failure Assessment (SOFA) score, which is difficult to calculate outside the ICU. Biomarkers could help to stratify the severity of infection in surgical patients.Methods: Levels of ten biomarkers indicating endothelial dysfunction, 22 indicating emergency granulopoiesis, and six denoting neutrophil degranulation were compared in three groups of patients in the first 12 h after diagnosis at three Spanish hospitals.Results: There were 100 patients with infection, 95 with sepsis and 57 with septic shock. Seven biomarkers indicating endothelial dysfunction (mid-regional proadrenomedullin (MR-ProADM), syndecan 1, thrombomodulin, angiopoietin 2, endothelial cell-specific molecule 1, vascular cell adhesion molecule 1 and E-selectin) had stronger associations with sepsis than infection alone. MR-ProADM had the highest odds ratio (OR) in multivariable analysis (OR 11⋅53, 95 per cent c.i. 4⋅15 to 32⋅08; P = 0⋅006) and the best area under the curve (AUC) for detecting sepsis (0⋅86, 95 per cent c.i. 0⋅80 to 0⋅91; P < 0⋅001). In a comparison of sepsis with septic shock, two biomarkers of neutrophil degranulation, proteinase 3 (OR 8⋅09, 1⋅34 to 48⋅91; P = 0⋅028) and lipocalin 2 (OR 6⋅62, 2⋅47 to 17⋅77; P = 0⋅002), had the strongest association with septic shock, but lipocalin 2 exhibited the highest AUC (0⋅81, 0⋅73 to 0⋅90; P < 0⋅001). Conclusion: MR-ProADM and lipocalin 2 could be alternatives to the SOFA score in the detection of sepsis and septic shock respectively in surgical patients with infection. Healthy control Infection Sepsis Septic shockBiomarkers of a,b emergency granulopoiesis and c acute-phase response. Levels of C-reactive protein (CRP) are in mg/l, those of procalcitonin (PCT) are in ng/ml, and those of the remaining biomarkers are copies of cDNA per ng mRNA. MMP, matrix metalloproteinase; LTF, lactoferrin; PRTN, proteinase; LCN, lipocalin, OLFM, olfactomedin; ELANE, elastase, neutrophil expressed; MPO, myeloperoxidase; CTSG, cathepsin G; AZU, azurocidin; BPI, bactericidal/permeability-increasing protein; DEFA, defensin α; CEACAM, carcinoembryonic antigen-related cell adhesion molecule; CD, cluster of differentiation; TCN, transcobalamin; STOM, stomatin; IL1R2, interleukin-1 receptor type 2; CHIT, chitinase. *P ≤ 0⋅050 versus healthy control;†P ≤ 0⋅050 (Kruskal-Wallis test).

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Diagnostic and prognostic value of neutrophil gelatinase-associated lipocalin, matrix metalloproteinase-9, and tissue inhibitor of matrix metalloproteinases-1 for sepsis in the Emergency Department: an observational study

Cited by 68 publications

References 34 publications

Diagnostic Value of Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis-Associated Acute Kidney Injury

Diagnostic Value of Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis-Associated Acute Kidney Injury

Neutrophil gelatinase-associated lipocalin as a potential therapeutic integrator of glycolipid metabolic and inflammatory signaling

Endothelial dysfunction is an early indicator of sepsis and neutrophil degranulation of septic shock in surgical patients

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