Diagnostic Consistency and Relation Between Optical Coherence Tomography and Standard Automated Perimetry in Primary Open-Angle Glaucoma

Toprak, İ̇brahim; Yaylalı, Volkan; Yıldırım, Cem

doi:10.3109/08820538.2015.1046557

Cited by 4 publications

(5 citation statements)

References 22 publications

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“…8, Aug.18, 2022 www.ijo.cn Tel: 8629-82245172 8629-82210956 Email: ijopress@163.com Evaluation of the peripapillary retinal nerve fiber layer (pRNFL) thickness enables clinicians to assess the degree and the pattern of the damage to the RGC axons coursing toward the ONH. Multiple quantitative retinal imaging techniques comprising scanning laser polarimetry, Heidelberg retinal tomography, as well as optical coherence tomography (OCT) [8][9][10][11][12][13] , have been utilized to measure RNFL thickness. Among them, spectral-domain optical coherence tomography (SD-OCT), which is the latest generation of OCT, provides a high-resolution and enhance-depth visualization of the retina and the ONH [14][15][16] .…”

Section: Oct Differentiates Naion and Poagmentioning

confidence: 99%

Optical coherence tomography evaluation of retinal nerve fiber layer thickness in non-arteritic anterior ischemic optic neuropathy and primary open angle glaucoma: a systematic review and Meta-analysis

Tong¹,

He²,

Chen³

et al. 2022

Int J Ophthalmol

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AIM: To assess the differences in average and sectoral peripapillary retinal nerve fiber layer (pRNFL) thickness using spectral domain optical coherence tomography (SD-OCT) in patients with non-arteritic anterior ischemic neuropathy (NAION) compared with those with primary open angle glaucoma (POAG). METHODS: A comprehensive literature search of the PubMed, Cochrane Library, and Embase databases were performed prior to October, 2021. Studies that compared the pRNFL thickness in NAION eyes with that in POAG eyes with matched mean deviation of the visual fields were included. The weighted mean difference (WMD) with 95% confidence interval (CI) was used to pool continuous outcomes. RESULTS: Ten cross-sectional studies (11 datasets) comprising a total of 625 eyes (278 NAION eyes, 347 POAG eyes) were included in the qualitative and quantitative analyses. The pooled results demonstrated that the superior pRNFL was significantly thinner in NAION eyes than in POAG eyes (WMD=-6.40, 95%CI: -12.22 to -0.58, P=0.031), whereas the inferior pRNFL was significant thinner in POAG eyes than in NAION eyes (WMD=11.10, 95%CI: 7.06 to 15.14, P≤0.001). No difference was noted concerning the average, nasal, and temporal pRNFL thickness (average: WMD=1.45, 95%CI: -0.75 to 3.66, P=0.196; nasal: WMD= -2.12, 95%CI: -4.43 to 0.19, P=0.072; temporal: WMD= -1.24, 95%CI: -3.96 to 1.47, P=0.370). CONCLUSION: SD-OCT based evaluation of inferior and superior pRNFL thickness can be potentially utilized to differentiate NAION from POAG, and help to understand the different pathophysiological mechanisms between these two diseases. Further longitudinal studies and studies using eight-quadrant or clock-hour classification method are required to validate the obtained findings.

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Section: Oct Differentiates Naion and Poagmentioning

confidence: 99%

Optical coherence tomography evaluation of retinal nerve fiber layer thickness in non-arteritic anterior ischemic optic neuropathy and primary open angle glaucoma: a systematic review and Meta-analysis

Tong¹,

He²,

Chen³

et al. 2022

Int J Ophthalmol

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“…Optical coherence tomography (OCT), as a non‐invasive laser technology, allows quantitative assessment of optic nerve head morphology and peripapillary retinal nerve fibre layer thickness, which has a critical importance in glaucoma diagnosis and follow‐up …”

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confidence: 99%

“…5,[15][16][17] Optical coherence tomography (OCT), as a non-invasive laser technology, allows quantitative assessment of optic nerve head morphology and peripapillary retinal nerve fibre layer thickness, which has a critical importance in glaucoma diagnosis and follow-up. 18 Previous literature comprises conflicting results from a number of studies investigating haemorrheological characteristics of patients with glaucoma based on different patient selection criteria (sample size, exclusion criteria, guidelines for the diagnosis of glaucoma, different stages of glaucoma and presence of hypertension) and methods used for determination of RBC deformability and aggregation. 2,5,[15][16][17][19][20][21] Furthermore, the relationship between haemorrheological parameters and optic nerve head morphology in patients with primary open angle glaucoma (POAG) is unclear.…”

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confidence: 99%

Increased erythrocyte aggregation in patients with primary open angle glaucoma

Kilic‐Toprak

Toprak

Kilic-Erkek

et al. 2016

Clinical and Experimental Optometry

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In patients with POAG, erythrocyte aggregation appears to be higher. It can be speculated that higher erythrocyte aggregation and deformability may be involved in the pathogenesis of glaucoma by affecting microperfusion of the optic nerve head and retina. Modification of rheological parameters in patients with glaucoma may be considered as an adjuvant future therapy in glaucoma management, whereas further studies in larger groups are needed.

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“…GCIPL and RNFL measurements by using OCT has been suggested as one means of early diagnosing glaucoma patients [ 14 – 19 ]. In our study we assessed diagnostic performances of GCIPL and RNFL parameters individually or in combination among cases of early glaucoma, glaucoma suspects and healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic performance of optical coherence tomography macular ganglion cell inner plexiform layer and retinal nerve fiber layer thickness in glaucoma suspect and early glaucoma patients at St. Paul’s hospital millennium medical college, Addis Ababa, Ethiopia

Abera

Gessesse

2023

PLoS ONE

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Purpose To evaluate glaucoma diagnostic performance of ganglion cell inner plexiform layer and retinal nerve fiber layer parameters measured with cirrus HD optical coherence tomography (OCT). Method Total of 188 eyes were included in our study. 49 eyes of healthy controls, 70 glaucoma suspect eyes and 69 early glaucomatous eyes. Complete ophthalmic examination was done including visual field test (with Humphrey field analyzer) and OCT scanning of ganglion cell inner plexiform layer (GCIPL) and retinal nerve fiber layer (RNFL) in different quadrants. Sensitivity, specificity and area under the receiver operating characteristic curve (AUROC) of each parameter was calculated to provide diagnostic ability between normal controls, glaucoma suspects or early glaucoma. Result GCIPL and RNFL parameters had strong power in discriminating early glaucoma from healthy controls with all having AUROC of above 0.76. Of all the GCIPL and RNFL parameters, the only variable that could discriminate between glaucoma suspect and healthy controls was the combined parameter by OR-logic approach. Of all the parameters, the average and nasal RNFL parameters had the strongest power in discriminating between the two with AUROC of 0.81. All parameters had an overall good diagnostic performance with excellent sensitivity but the specificity was relatively poor. The combined parameter had the best specificity (62.2%) with excellent sensitivity (93.5%). Conclusion Nasal RNFL parameters had the strongest power in discriminating between glaucoma suspect and healthy controls and the OR-logic combination of RNFL and GCIPL provides better diagnostic performance than single GCIPL, RNFL or ONH parameter.

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Diagnostic Consistency and Relation Between Optical Coherence Tomography and Standard Automated Perimetry in Primary Open-Angle Glaucoma

Cited by 4 publications

References 22 publications

Optical coherence tomography evaluation of retinal nerve fiber layer thickness in non-arteritic anterior ischemic optic neuropathy and primary open angle glaucoma: a systematic review and Meta-analysis

Optical coherence tomography evaluation of retinal nerve fiber layer thickness in non-arteritic anterior ischemic optic neuropathy and primary open angle glaucoma: a systematic review and Meta-analysis

Increased erythrocyte aggregation in patients with primary open angle glaucoma

Diagnostic performance of optical coherence tomography macular ganglion cell inner plexiform layer and retinal nerve fiber layer thickness in glaucoma suspect and early glaucoma patients at St. Paul’s hospital millennium medical college, Addis Ababa, Ethiopia

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