Diagnostic de rejet de greffe cardiaque : intérêt potentiel des marqueurs cardiaques et de la réponse inflammatoire

Cauliez, Bruno; Redonnet, M; Ménard, J. F.; Guignery, J; Marinier, S; Lavoinne, Alain

doi:10.1016/s0923-2532(00)80043-5

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…Eleven studies ( 34 , 37 , 42 , 45 , 47 , 49 , 50 , 52 – 55 ) with 641 participants reported troponin mean differences between those with and without acute cellular rejection. We found that the standardised troponin measurements were not significantly different in those with and without acute cellular rejection (SMD 0.49, 95% CI −0.33–1.31) ( Figure 3 ).…”

Section: Resultsmentioning

confidence: 99%

Elevated Cardiac Troponin to Detect Acute Cellular Rejection After Cardiac Transplantation: A Systematic Review and Meta-Analysis

Liu¹,

Perry²,

Penny-Dimri³

et al. 2022

Transpl Int

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Cardiac troponin is well known as a highly specific marker of cardiomyocyte damage, and has significant diagnostic accuracy in many cardiac conditions. However, the value of elevated recipient troponin in diagnosing adverse outcomes in heart transplant recipients is uncertain. We searched MEDLINE (Ovid), Embase (Ovid), and the Cochrane Library from inception until December 2020. We generated summary sensitivity, specificity, and Bayesian areas under the curve (BAUC) using bivariate Bayesian modelling, and standardised mean differences (SMDs) to quantify the diagnostic relationship of recipient troponin and adverse outcomes following cardiac transplant. We included 27 studies with 1,684 cardiac transplant recipients. Patients with acute rejection had a statistically significant late elevation in standardised troponin measurements taken at least 1 month postoperatively (SMD 0.98, 95% CI 0.33–1.64). However, pooled diagnostic accuracy was poor (sensitivity 0.414, 95% CrI 0.174–0.696; specificity 0.785, 95% CrI 0.567–0.912; BAUC 0.607, 95% CrI 0.469–0.723). In summary, late troponin elevation in heart transplant recipients is associated with acute cellular rejection in adults, but its stand-alone diagnostic accuracy is poor. Further research is needed to assess its performance in predictive modelling of adverse outcomes following cardiac transplant.Systematic Review Registration: identifier CRD42021227861

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Section: Resultsmentioning

confidence: 99%

Elevated Cardiac Troponin to Detect Acute Cellular Rejection After Cardiac Transplantation: A Systematic Review and Meta-Analysis

Liu¹,

Perry²,

Penny-Dimri³

et al. 2022

Transpl Int

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show abstract

“…Continuous Measure of Diagnostic Accuracy. Eleven studies (34,37,42,45,47,49,50,(52)(53)(54)(55) with 641 participants reported troponin mean differences between those with and without acute cellular rejection. We found that the standardised troponin measurements were not significantly different in those with and without acute cellular rejection (SMD 0.49, 95% CI −0.33-1.31) (Figure 3).…”

Section: Methodological Qualitymentioning

confidence: 99%

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Diagnostic de rejet de greffe cardiaque : intérêt potentiel des marqueurs cardiaques et de la réponse inflammatoire

Cited by 2 publications

References 8 publications

Elevated Cardiac Troponin to Detect Acute Cellular Rejection After Cardiac Transplantation: A Systematic Review and Meta-Analysis

Elevated Cardiac Troponin to Detect Acute Cellular Rejection After Cardiac Transplantation: A Systematic Review and Meta-Analysis

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