Diagnostic devices for osteoporosis in the general population: A systematic review

Høiberg, Mikkel; Rubin, Katrine Hass; Hermann, Anne Pernille; Brixen, Kim; Abrahamsen, Bo

doi:10.1016/j.bone.2016.08.011

Cited by 45 publications

(38 citation statements)

References 71 publications

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“…DXA and QUS measurements are performed at different skeletal sites and not directly comparable, which may explain the different findings. DXA and QUS provide complementary information on bone status and are independently linked . However, a DXA measurement is the gold standard for diagnosing osteoporosis .…”

Section: Discussionmentioning

confidence: 99%

“…However, a DXA measurement is the gold standard for diagnosing osteoporosis . Although QUS is currently not recommended to be used in the diagnosis of osteoporosis, it may be capable to replace DXA in the future . Further, it may be of additional value even after a DXA scan has been performed .…”

Section: Discussionmentioning

confidence: 99%

“…DXA and QUS provide complementary information on bone status and are independently linked. 34 However, a DXA measurement is the gold standard for diagnosing osteoporosis. 1 Although QUS is currently not recommended to be used in the diagnosis of osteoporosis, 35 it may be capable to replace DXA in the future.…”

Section: Associations Between Igf-i and Bone Health Have Been Detectementioning

confidence: 99%

See 2 more Smart Citations

Associations of insulin‐like growth factor‐I and insulin‐like growth factor binding protein‐3 with bone quality in the general adult population

Böker

Völzke

Nauck

et al. 2018

Clinical Endocrinology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Associations Between Igf-i and Bone Health Have Been Detectementioning

confidence: 99%

See 1 more Smart Citation

Associations of insulin‐like growth factor‐I and insulin‐like growth factor binding protein‐3 with bone quality in the general adult population

Böker

Völzke

Nauck

et al. 2018

Clinical Endocrinology

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show abstract

“…Several other methods are available, with most using a form of radiograph or CT scan. Recently, more evidence supports the use of ultrasound in the diagnosis of osteoporosis, which carries the benefit of no radiation exposure, is readily available, and is cost-effective for an office setting [103][104][105][106]. However, its cost-effectiveness when compared to DXA has been called into question and it may serve as a more appropriate tool for pre-screening patients prior to DXA or where DXA is not readily available [103,107].…”

Section: Diagnostic Modalitiesmentioning

confidence: 99%

Osteoporosis: a discussion on the past 5 years

Schweser

Crist

2017

Curr Rev Musculoskelet Med

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Purpose of the review The purposes of this study are to examine the literature within the past 5 years regarding osteoporosis and offer a discussion on new topics and controversies. -Ultrasound may be cost-effective for diagnosis. Summary Understanding of osteoporosis has come a long way in the medical community, but the translation to the lay community has lagged behind. Patients often take a laissezfaire attitude toward osteoporosis that can affect compliance. Information read by patients often focuses on complications, such as atypical femur fractures and myocardial infarctions. It is essential for providers to be able to discuss these issues with patients. Newer medications and more cost-effective diagnostic tests exist, but availability may be limited. FLS are effective, but the most cost-effective model for therapy still eludes us. Areas for further investigation include FLS models, the effectiveness of vitamin supplementation, and more ubiquitous and cost-effective diagnostic tools.

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“…1,2 OP is a systemic bone metabolism disorder with increased bone loss and fracture risk. 3,4 OP occurs when the equilibrium of bone resorption and bone formation is disturbed. 5 As such, there are two main strategies in OP therapy: to enhance new bone formation and inhibit bone resorption.…”

Section: Introductionmentioning

confidence: 99%

A bone-resorption surface-targeting nanoparticle to deliver anti-miR214 for osteoporosis therapy

Cai

Yang

Zhang

et al. 2017

IJN

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With increasing fracture risks due to fragility, osteoporosis is a global health problem threatening postmenopausal women. In these patients, osteoclasts play leading roles in bone loss and fracture. How to inhibit osteoclast activity is the key issue for osteoporosis treatment. In recent years, miRNA-based gene therapy through gene regulation has been considered a potential therapeutic method. However, in light of the side effects, the use of therapeutic miRNAs in osteoporosis treatment is still limited by the lack of tissue/cell-specific delivery systems. Here, we developed polyurethane (PU) nanomicelles modified by the acidic peptide Asp 8 . Our data showed that without overt toxicity or eliciting an immune response, this delivery system encapsulated and selectively deliver miRNAs to OSCAR + osteoclasts at bone-resorption surface in vivo. With the Asp 8 -PU delivery system, anti-miR214 was delivered to osteoclasts, and bone microarchitecture and bone mass were improved in ovariectomized osteoporosis mice. Therefore, Asp 8 -PU could be a useful bone-resorption surface-targeting delivery system for treatment of osteoclast-induced bone diseases and aging-related osteoporosis.

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Diagnostic devices for osteoporosis in the general population: A systematic review

Cited by 45 publications

References 71 publications

Associations of insulin‐like growth factor‐I and insulin‐like growth factor binding protein‐3 with bone quality in the general adult population

Associations of insulin‐like growth factor‐I and insulin‐like growth factor binding protein‐3 with bone quality in the general adult population

Osteoporosis: a discussion on the past 5 years

A bone-resorption surface-targeting nanoparticle to deliver anti-miR214 for osteoporosis therapy

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