2014
DOI: 10.1007/s10120-013-0332-0
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Diagnostic performance and limitations of magnifying narrow-band imaging in screening endoscopy of early gastric cancer: a prospective multicenter feasibility study

Abstract: Background Curative treatment of patients with gastric cancer requires reliable detection of early gastric cancer. Magnifying endoscopy with narrow-band imaging (M-NBI) is useful for the accurate preoperative diagnosis of early gastric cancer. However, the role of M-NBI in screening endoscopy has not been established. The aims of this study were to determine the feasibility and limitations of M-NBI in screening endoscopy. Methods We conducted a multicenter prospective uncontrolled trial of patients undergoing … Show more

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Cited by 134 publications
(171 citation statements)
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References 30 publications
(37 reference statements)
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“…On the basis of this standard, published studies have reported that ME-NBI has a high diagnostic efficacy. However, there is a large difference in the sensitivity among these studies, ranging from 0.60 to 0.97 [13,14,18]. To our knowledge, our study is the first meta-analysis focusing on systematically evaluating the diagnostic efficacy of ME-NBI for early gastric cancer.…”
Section: Discussionmentioning
confidence: 98%
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“…On the basis of this standard, published studies have reported that ME-NBI has a high diagnostic efficacy. However, there is a large difference in the sensitivity among these studies, ranging from 0.60 to 0.97 [13,14,18]. To our knowledge, our study is the first meta-analysis focusing on systematically evaluating the diagnostic efficacy of ME-NBI for early gastric cancer.…”
Section: Discussionmentioning
confidence: 98%
“…Some reports have demonstrated there are certain differences between the pathologic findings for biopsy specimens and ESD specimens, with a reported incompatible rate of 27.1-44.5 % [28]. ME-NBI can assist in targeting the biopsy site, and immediate endoscopic diagnosis of gastric cancer by ME-NBI can be considered as an optical biopsy [14,27,29]. However, the performance of ME-NBI is also affected by the blood and bile in the stomach.…”
Section: Discussionmentioning
confidence: 99%
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“…However, it is often difficult to detect gastric superficial adenocarcinomas using conventional endoscopy with white-light imaging (C-WLI). Many clinical studies have reported on the diagnostic performance of EGC by imageenhanced endoscopy (IEE) techniques such as narrow-band imaging (NBI) [2][3][4][5][6][7][8][9] or flexible spectral imaging color enhancement (FICE) [10][11][12]. In particular, magnifying endoscopy with NBI (M-NBI) is a powerful optical IEE that has demonstrated accurate real-time diagnostic performance in EGC compared with C-WLI [5,7].…”
Section: Introductionmentioning
confidence: 99%