Diagnostic performance of two-dimensional shear wave elastography for evaluating tibial nerve stiffness in patients with diabetic peripheral neuropathy

Jiang, Weixi; Huang, Sirun; Teng, Hua; Wang, Peipei; Wu, Meng; Zhou, Xia; Xu, Wei; Zhang, Qunxia; Ran, Haitao

doi:10.1007/s00330-018-5858-4

Cited by 36 publications

(46 citation statements)

References 28 publications

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“…Using SWE, patients with type 2 diabetes mellitus with clinical diabetic peripheral neuropathy (DPN), with or without electrodiagnostic evidence of peripheral neuropathy, demonstrated greater stiffness of the tibial nerve at the ankle compared with diabetic patients without DPN and normal subjects. [49][50][51][52] The increase in nerve stiffness was greater as the severity of neuropathy increased. 52 Of interest, there is increased tibial nerve stiffness in diabetic patients without DPN suggesting that elastography may be able to detect DPN before it becomes evident clinically or on nerve conduction studies.…”

Section: Peripheral Polyneuropathymentioning

confidence: 97%

“…25 In disease states, similar inter-and intra-observer agreement was also reported in studies using SWE in patients with CTS and DPN. 27,28,40,49,50 However, technical factors, such as the degree of pressure applied through the probe, the angle of insonation, and the amount of gel under the probe all affect elastography studies. As such, a careful approach in the clinic is needed to translate the excellent inter-and intra-observer agreement seen in controlled research setting into clinical practice.…”

Section: The Effect Of Ultrasound Machine Transducersmentioning

confidence: 99%

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Ultrasound elastography for the evaluation of peripheral nerves: A systematic review

Wee

Simon

2019

Muscle and Nerve

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Peripheral nerve disorders are commonly encountered in clinical practice. Electrodiagnostic studies remain the cornerstone of the evaluation of nerve disorders. More recently, ultrasound has played an increasing complementary role in the neuromuscular clinic. Ultrasound elastography is a technique that measures the elastic properties of tissues. Given the histological changes that occur in diseased peripheral nerves, nerve ultrasound elastography has been explored as a noninvasive way to evaluate changes in nerve tissue composition. Studies to date suggest that nerve stiffness tends to increase in the setting of peripheral neuropathy, regardless of etiology, consistent with loss of more compliant myelin, and replacement with connective tissue. The aim of this systematic review is to summarize the current literature on the use of ultrasound elastography in the evaluation of peripheral neuropathy. Limitations of ultrasound elastography and gaps in current literature are discussed, and prospects for future clinical and research applications are raised.

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Section: Peripheral Polyneuropathymentioning

confidence: 97%

Section: The Effect Of Ultrasound Machine Transducersmentioning

confidence: 99%

Ultrasound elastography for the evaluation of peripheral nerves: A systematic review

Wee

Simon

2019

Muscle and Nerve

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“…Shear wave ultrasound elastography has the potential to be used as an adjunct method for assessing nerve impairment noninvasively by estimation of mechanical properties such as stiffness. Despite its relatively novel application to nerve, the feasibility of SW ultrasound elastography as a clinical measure is supported by previous findings that have demonstrated greater nerve SW velocity in metabolic and entrapment neuropathies. However, our findings provide evidence that the relationship between SW velocity and mechanical properties, such as stiffness, is complicated by the influence of nerve tension in vivo.…”

Section: Discussionmentioning

confidence: 94%

“…More recently, noninvasive real‐time estimation of nerve mechanical properties, such as stiffness, has been made possible with the advent of shear wave (SW) ultrasound elastography, a technique that induces SWs and measures their velocity. Early reports of studies described finding that in vivo measurements of SW velocity in nerve tissue are greater in patients with nerve damage, including metabolic and entrapment neuropathies. This trend mirrors findings from pathological studies of other tissues including breast, liver, and passive skeletal muscle, for which greater SW velocity is largely attributed to changes in collagen content and structure.…”

Section: Introductionmentioning

confidence: 99%

Influence of limb position on assessment of nerve mechanical properties by using shear wave ultrasound elastography

2020

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Introduction: Evaluation of nerve mechanical properties has the potential to improve assessment of nerve impairment. Shear wave velocity, as measured by using shear wave (SW) ultrasound elastography, is a promising indicator of nerve mechanical properties such as stiffness. However, elucidation of external factors that influence SW velocity, particularly nerve tension, is required for accurate interpretations.Methods: Median and ulnar nerve SW velocities were measured at proximal and distal locations with limb positions that indirectly altered nerve tension.Results: Shear wave velocity was greater at proximal and distal locations for limb positions that induced greater tension in the median (mean increase proximal 89.3%, distal 64%) and ulnar (mean increase proximal 91.1%, distal 37.4%) nerves.Discussion: Due to the influence of nerve tension when SW ultrasound elastography is used, careful consideration must be given to limb positioning. K E Y W O R D S mechanical properties, nerve cross-sectional area, neuromuscular ultrasound, peripheral nerve, shear wave ultrasound elastography, tension

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“…[33][34][35] Peripheral nerve stiffness increases in patients with diabetic peripheral neuropathy. [36][37][38] Finally, patients with unilateral lumbar disk herniation have increased stiffness of the sciatic nerve compared with the noninvolved side. 39 With regard to soft tissue masses, shear-wave elastography can increase the accuracy of diagnosis in conjunction with gray-scale US.…”

mentioning

confidence: 99%

Quantitative Musculoskeletal Ultrasound

Gitto

Messina

Vitale

et al. 2020

Semin Musculoskelet Radiol

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Ultrasound (US) imaging plays a crucial role in the assessment of musculoskeletal (MSK) disorders. Several quantitative tools are offered by US systems and add information to conventional US imaging. This article reviews the quantitative US imaging tools currently available in MSK radiology, specifically focusing on the evaluation of elasticity with shear-wave elastography, perfusion with contrast-enhanced US and noncontrast superb microvascular imaging, and bone and muscle mass with quantitative US methods. Some of them are well established and already of clinical value, such as elasticity and contrast-enhanced perfusion assessment in muscles and tendons. MSK radiologists should be aware of the potential of quantitative US tools and take advantage of their use in everyday practice, both for clinical and research purposes.

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Diagnostic performance of two-dimensional shear wave elastography for evaluating tibial nerve stiffness in patients with diabetic peripheral neuropathy

Cited by 36 publications

References 28 publications

Ultrasound elastography for the evaluation of peripheral nerves: A systematic review

Ultrasound elastography for the evaluation of peripheral nerves: A systematic review

Influence of limb position on assessment of nerve mechanical properties by using shear wave ultrasound elastography

Quantitative Musculoskeletal Ultrasound

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