Diagnostic surprise on IHC: A rare case of intramuscular DLBCL in thigh region mimicking sarcoma

Abstract

Soft tissue sarcomas are broad group of malignant tumours that arise in tissues like fat, muscle, nerves, fibrous tissue and blood vessels. A variety of non mesenchymal neoplasms like sarcomatoid carcinomas, melanomas and extranodal lymphomas may also mimic soft tissue sarcoma. Diffuse Large BCell Lymphoma is the most common type of Non HodgkinsLymphoma accounting for around 30-40% of cases.DLBCL involving skeletal muscle is extremely rare accounting approximately <1% of the cases with most of the cases reported in the lower extremity involving calf and thigh region.Here we report a case of DLBCL of the left thigh mass in 60 years old male which was initially thought to be a sarcoma based on clinical findings and imaging, but was later diagnosed to be DLBCL after surgical excision of the mass with the help of histopathology and immunohistochemistry.

Primary Skeletal Muscle Diffuse Large B Cell Lymphoma in Lumbar Region – A Rare Occurrence

“…All these were clinically suspected to be sarcomas and most cases involved the extremities. 8,9,10 Uncommon sites include back, abdominal wall, pelvis and gluteal region. 7 Our case is a primary skeletal muscle lymphoma presenting at the lumbar region of the back (which is an unusual site).…”

Implicación de la expresión condicional de HGAL en modelos murinos de linfoma de células grandes B difuso

“…Así, se evidencia que el linfoma de células grandes B difuso constituye una patología oncohematológica muy heterogénea no solo a nivel genético, sino a nivel clínico y fenotípico (Figura 4) [112][113][114][115] . Por tanto, el estudio y análisis de esta heterogeneidad es de vital importancia para una comprensión, diagnóstico y pronóstico más profusos y exhaustivos en una enfermedad que aún, en la actualidad, es responsable de un importante número de defunciones 40,79,[116][117][118] .…”