Diagnostic test pepsinogen I and combination with tumor marker CEA in gastric cancer

Sembiring, Juwita; Sarumpaet, K.; Ganie, Ratna Akbari

doi:10.1088/1755-1315/125/1/012138

Cited by 6 publications

(6 citation statements)

References 11 publications

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“…Actually, the combination of serum PG and other indicators is successfully used for the prediction of GC [29]. Sembiring J et al have shown that PGI combined with CEA can be used for the diagnosis of GC from non-GC individuals with a sensitivity of 94.1% and a specificity of 80% [30]. Niu WW et al have indicated that the sensitivity and specificity of miR-92a combined with PG on GC is 86.49 and 89.32%, respectively [31].…”

Section: Discussionmentioning

confidence: 99%

Serum miR-101-3p combined with pepsinogen contributes to the early diagnosis of gastric cancer

et al. 2020

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Background: This study aimed to explore the diagnostic value of serum miR-101-3p combined with pepsinogen (PG) on early diagnosis of gastric cancer (GC). Methods: A total of 61 atrophic gastritis (AG) and 86 GC patients, and 50 healthy volunteers were enrolled. The serum expression of miR-101-3p was measured by qRT-PCR. The serum content of carcinoembryonic antigen (CEA) was measured by Electrochemiluminescence immunoassay. The serum contents of PGI and PGII were measured by Enzyme linked immunosorbent assay. The diagnostic value of serum markers on AG and GC was analyzed by receiver operating characteristic (ROC) analysis.Results: The expression of miR-101-3p, the content of PGI and the ratio of PGI/II were significantly decreased, and the content of PGII was significantly increased in AG patients compared with those in normal controls. The changes of the above serum indicators were more obvious in GC patients than those in AG patients. The content of CEA was significantly higher in GC patients than that in AG patients. In addition, the expression of miR-101-3p was negatively associated with the submucosal infiltration in GC patients. MiR-101-3p exhibited high diagnostic value on AG (AUC 0.8493, sensitivity 80.33%, specificity 80%) and GC (AUC 0.8749, sensitivity 72.09%, specificity 86.49%). MiR-101-3p + PGI + PGI/II (AUC 0.856, sensitivity 80.23%, specificity 77.05%) exhibited a high diagnostic value in distinguishing between AG and GC.Conclusions: MiR-101-3p was a potential diagnostic marker for AG and GC. MiR-101-3p + PGI + PGI/II was effective in distinguishing between AG and GC.

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Section: Discussionmentioning

confidence: 99%

Serum miR-101-3p combined with pepsinogen contributes to the early diagnosis of gastric cancer

et al. 2020

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“…Sembiring J et al have shown that PGI combined with CEA can be used for the diagnosis of GC from non-GC individuals with a sensitivity of 94.1% and a specificity of 80% 30 . Niu WW et al have indicated that the sensitivity and specificity of miR-92a combined with PG on GC is 86.49% and 89.32%, respectively 31 .…”

Section: Discussionmentioning

confidence: 99%

Serum miR-101-3p combined with pepsinogen contributes to the early diagnosis of gastric cancer

Zeng

Zhang

Yang

et al. 2020

Preprint

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Background: This study aimed to explore the diagnostic value of serum miR-101-3p combined with pepsinogen (PG) on early diagnosis of gastric cancer (GC).Methods: A total of 61 atrophic gastritis (AG) and 86 GC patients, and 50 healthy volunteers were enrolled. The serum expression of miR-101-3p was measured by qRT-PCR. The serum content of carcinoembryonic antigen (CEA) was measured by Electrochemiluminescence immunoassay. The serum contents of PGI and PGII were measured by Enzyme linked immunosorbent assay. The diagnostic value of serum markers on AG and GC was analyzed by receiver operating characteristic (ROC) analysis.Results: The expression of miR-101-3p, the content of PGI and the ratio of PGI/II were significantly decreased, and the content of PGII was significantly increased in AG patients compared with those in normal controls. The changes of the above serum indicators were more obvious in GC patients than those in AG patients. The content of CEA was significantly higher in GC patients than that in AG patients. In addition, the expression of miR-101-3p was negatively associated with the submucosal infiltration in GC patients. MiR-101-3p exhibited high diagnostic value on AG (AUC 0.8493, sensitivity 80.33%, specificity 80%) and GC (AUC 0.8749, sensitivity 72.09%, specificity 86.49%). MiR-101-3p + PGI + PGI/II (AUC 0.856, sensitivity 80.23%, specificity 77.05%) exhibited a high diagnostic value in distinguishing between AG and GC.Conclusions: MiR-101-3p was a potential diagnostic marker for AG and GC. MiR-101-3p + PGI + PGI/II was effective in distinguishing between AG and GC.

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“…Actually, the combining of serum PG and other indicators is successfully used for the prediction of GC development 32 . A recent diagnostic test PGI and combination with tumor marker CEA in 32 patients suspected with GC shows that PGI + CEA can be used for diagnosis of GC from non-GC individual with sensitivity of 94.1% and specificity of 80% 33 . Niu et al indicates that there was a high diagnostic value of miR-92a combined with PG in GC development 34 .…”

Section: Discussionmentioning

confidence: 99%

Serum miR-101-3p combined with pepsinogen contribute to the early diagnosis of gastric cancer

Zeng

Zhang

Yang

et al. 2019

Preprint

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Background This study aimed to explore the effect of serum miR-101-3p combined with pepsinogen (PG) on early diagnosis of gastric cancer (GC).Methods The peripheral blood was isolated from patients with atrophic gastritis (AG), GC and healthy individuals respectively. RT-qPCR was used to detect the expression of miR-101-3p. Electrochemiluminescence (ECL) was used to reveal the carcinoembryonic antigen (CEA) expression level. Moreover, the expression of PGI and PGII was detected by ELISA. Furthermore, the area under the receiver operating characteristic (ROC) curve (AUC) was used to analyze the diagnostic efficacy of miR-101-3p and PG in early GC patients, AG patients and healthy individuals.Results There were significant differences in the expression levels of miR-101-3p, PGI and PGI/II ratio among groups (all P < 0.05). Serum miR-101-3p expression was correlated with process of invasion (P = 0.03). The miR-101-3p + PGI/II and miR-101-3p + PGI + PGI/PGII have higher diagnostic value (AUC) in AG (all P < 0.05). Meanwhile, miR-101-3p + PGI, miR-101-3p + PGI/II and miR-101-3p + PGI + PGI/II have higher AUC in GC (all P < 0.05). Moreover, miR-101-3p + PGI + PGI/II significantly (P < 0.05) improved the value of each indicator in individual diagnosis (sensitivity: 80.23, specificity: 77.05)Conclusions The miR-101-3p might take part in the progression of GC via influencing cell invasion. Furthermore, miR-101-3p + PG might be used as a novel marker for clinical diagnosis of GC.

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Diagnostic test pepsinogen I and combination with tumor marker CEA in gastric cancer

Cited by 6 publications

References 11 publications

Serum miR-101-3p combined with pepsinogen contributes to the early diagnosis of gastric cancer

Serum miR-101-3p combined with pepsinogen contributes to the early diagnosis of gastric cancer

Serum miR-101-3p combined with pepsinogen contributes to the early diagnosis of gastric cancer

Serum miR-101-3p combined with pepsinogen contribute to the early diagnosis of gastric cancer

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