Diagnostic tests for immunomediated hearing loss: a systematic review

Lobo, David; López, Fernando García; Garcia-Berrocal, J. J. R.; Ramírez‐Camacho, Rafael

doi:10.1017/s002221510700059x

Cited by 22 publications

(4 citation statements)

References 63 publications

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“…The analysis of immunological parameters using specific laboratory tests was performed without obtaining conclusive results [ 5 , 11 , 23 , 38 , 39 ]. A statistically significant relationship ( p = 0.029) between SNHL diagnosed using HFA and anti-cardiolipin (aCL) positivity (OR < 1) was observed.…”

Section: Resultsmentioning

confidence: 99%

Examination of Hearing in a Rheumatoid Arthritis Population: Role of Extended-High-Frequency Audiometry in the Diagnosis of Subclinical Involvement

et al. 2016

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Objective. The aim of this study is to analyze the high-frequency hearing levels in patients with rheumatoid arthritis and to determine the relationship between hearing loss, disease duration, and immunological parameters. Materials and Methods. A descriptive cross-sectional study including fifty-three patients with rheumatoid arthritis was performed. The control group consisted of 71 age- and sex-matched patients from the study population (consecutively recruited in Madrid “Area 9,” from January 2010 to February 2011). Both a pure tone audiometry and an extended-high-frequency audiometry were performed. Results. Extended-high-frequency audiometry diagnosed sensorineural hearing loss in 69.8% of the patients which exceeded the results obtained with pure tone audiometry (43% of the patients). This study found significant correlations in patients with sensorineural hearing loss related to age, sex, and serum anti-cardiolipin (aCL) antibody levels. Conclusion. Sensorineural hearing loss must be considered within the clinical context of rheumatoid arthritis. Our results demonstrated that an extended-high-frequency audiometry is a useful audiological test that must be performed within the diagnostic and follow-up testing of patients with rheumatoid arthritis, providing further insight into a disease-modifying treatment or a hearing loss preventive treatment.

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Section: Resultsmentioning

confidence: 99%

Examination of Hearing in a Rheumatoid Arthritis Population: Role of Extended-High-Frequency Audiometry in the Diagnosis of Subclinical Involvement

et al. 2016

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“…A recent systematic review of the diagnostic tests used for autoimmune hearing loss revealed significant heterogeneity and a lack of standardization across the literature. 35 The relevant studies in this review were able to identify significant elevations in nonspecific inflammatory markers and identify significant changes in autoantibodies and cellular changes in SSNHL patients. 2,16,18 None of the studies were able to identify an inflammatory marker specific for autoimmune inner ear disease, as all of the reviewed studies' findings have been previously associated with other systemic inflammatory diseases.…”

Section: Autoimmune Diseasementioning

confidence: 95%

Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss

et al. 2010

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The suspected etiologies for patients suffering sudden sensorineural hearing loss included idiopathic (71.0%), infectious disease (12.8%), otologic disease (4.7%), trauma (4.2%), vascular or hematologic (2.8%), neoplastic (2.3%), and other causes (2.2%). Establishment of a direct causal link between SSNHL and these etiologies remains elusive. Diagnostic imaging is a useful method for identification of temporal bone or intracranial pathology that can present with SSNHL as a primary symptom.

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“…In certain cases, serological studies can detect some specific autoantibodies, but there are no immunological or serological tests that are specific or sensitive enough to establish a definitive diagnosis [18] . A summary of the main specific and non-specific autoantibodies found in AIED patients and experimental models is given in Table 1.…”

Section: Diagnosismentioning

confidence: 99%

New prospects in the diagnosis and treatment of immune-mediated inner ear disease

Lobo

García-Berrocal

Ramírez‐Camacho

2014

WJM

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Autoimmune inner ear disease (AIED) represents a very fertile research field and the advancements in the understanding of this disease have a direct application not only in patients affected with this condition but also in other inner ear disorders that share the same injury mechanism, damage to the inner ear hair cells. AIED also presents many challenges that have still to be overcome. Firstly, access to the inner ear is limited, as many interventions such as biopsies can result in great irreversible damage. Secondly, there are no completely specific markers for AIED. Lack of a definitive diagnosis can result in the treatment of patients not affected with the disease and, therefore, no response. Finally, some patients become refractory to glucocorticoids and new therapies are needed. This review offers an overview of the animal models that have contributed to the understanding of AIED pathophysiology, the value of currently available diagnostic tests, and therapeutic options, with a special focus on new therapies for non responders or patients refractory to glucocorticoids. Among these new options for therapy, biological agents have been tested recently, whereas gene and stem cell therapy may have a role in the future. The intratympanic route of administration avoids the systemic side effects associated with currently used drugs, and may become a more frequent approach in the future.© 2014 Baishideng Publishing Group Inc. All rights reserved. Key words: Autoimmune inner ear disease; Diagnostic tests; Biologic therapy agents; Gene therapy; Stem cellsCore tip: Readers interested in inner ear pathology will find in this review a brief summary of autoimmune inner ear disease, with special focus on the major advances achieved in the knowledge of its etiology and pathophysiology, and the diagnostic and therapeutic challenges that remain and may guide research in the next few years and beyond.Lobo DR, García-Berrocal JR, Ramirez-Camacho R. New prospects in the diagnosis and treatment of immune-mediated inner ear disease. World J Methodol 2014; 4(2): 91-98 Available from:

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Diagnostic tests for immunomediated hearing loss: a systematic review

Cited by 22 publications

References 63 publications

Examination of Hearing in a Rheumatoid Arthritis Population: Role of Extended-High-Frequency Audiometry in the Diagnosis of Subclinical Involvement

Examination of Hearing in a Rheumatoid Arthritis Population: Role of Extended-High-Frequency Audiometry in the Diagnosis of Subclinical Involvement

Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss

New prospects in the diagnosis and treatment of immune-mediated inner ear disease

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