Diagnostic value of CEA, CA 15-3, CA 19-9, CYFRA 21-1, NSE and TSA assay in pleural effusions

Alataş, Füsun; Alataş, Özkaņ; Metintaş, Muzaffer; Çolak, Ömer; Harmancı, Emel; Demir, Şükrü Saygın

doi:10.1016/s0169-5002(00)00153-7

Cited by 107 publications

(105 citation statements)

References 20 publications

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“…[27][28][29] In our study, CEA alone had a sensitivity of 76.5% and accuracy of 80.4%, in agreement with earlier results. 27 CEA synthesis is known to be increased by malignant cells. It has been suggested that decreased lymphatic drainage due to the obstruction of the lymphatic drainage by malignant cells and invasions may increase effusion CEA levels.…”

Section: Discussionsupporting

confidence: 93%

Detection of cell‐free BIRC5 mRNA in effusions and its potential diagnostic value for differentiating malignant and benign effusions

Wang

Qian

Wang

et al. 2009

Intl Journal of Cancer

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The detection of circulating nucleic acids has long been explored for the diagnosis of a variety of clinical conditions. The aim of this study was to detect the cell-free mRNA expression of BIRC5 in patients with effusions and assess its potential diagnostic value. Pleural fluids and ascites samples were collected prospectively from 112 patients. The cell-free RNA was extracted from effusions and the mRNA expression of BIRC5 was detected using real-time RT-PCR. The expression of carcinoembryonic antigen (CEA) and biochemical markers in effusions was also assayed. Effusions were classified as benign or malignant on the basis of their definitive pathologic or cytologic diagnoses. The expression of cell-free BIRC5 mRNA was statistically significantly higher in the malignant group than in the benign group. BIRC5 mRNA was also significantly different between patients with Stage III and Stage IV non-small cell lung cancers. The sensitivity and diagnostic accuracy of BIRC5 were 79.0 and 81.3%, whereas a combination of CEA and BIRC5 reached 86.4% sensitivity and 88.4% accuracy. These results indicate that effusions with higher levels of cell-free BIRC5 mRNA are more likely to be malignant. Determination of BIRC5 and CEA in effusions could enhance diagnostic value in the diagnosis of malignant effusions. ' 2009 UICC

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Section: Discussionsupporting

confidence: 93%

Detection of cell‐free BIRC5 mRNA in effusions and its potential diagnostic value for differentiating malignant and benign effusions

Wang

Qian

Wang

et al. 2009

Intl Journal of Cancer

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“…CA15-3 has previously been found in several small scale studies to be elevated in the serum (Alatas et al, 2001) and in effusions of patients with mesothelioma (Miedouge et al, 1999;Alatas et al, 2001) (Villena et al, 2003). In the current study, CA15-3 levels were significantly higher in the serum of mesothelioma patients than healthy controls; however, the finding that levels were elevated in patients with benign lung and pleural disease suggests that serum CA15-3 will not be useful as a diagnostic aid for mesothelioma.…”

Section: Discussionmentioning

confidence: 91%

Overexpression and altered glycosylation of MUC1 in malignant mesothelioma

et al. 2008

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Current interest in the MUC1/EMA mucin relates to its role in malignancy, and its potential as a therapeutic target. MUC1/EMA expression has been observed in the majority of epithelioid mesotheliomas. However, little is known of the characteristics of MUC1/ EMA in mesothelioma. Herein, we studied the cell surface and soluble expression of the MUC1/EMA glycoprotein, and determined the mRNA and genomic expression profiles in mesothelioma. We found that the anti-MUC1 antibody, E29, was the most diagnostically useful of seven antibody clones examined with a sensitivity of 84% (16 out of 19 cases) and no false positive results. MUC1 mRNA expression was significantly higher in mesothelioma samples than in benign mesothelial cells. No amplification of the MUC1 gene was observed by FISH. Seven of 9 mesothelioma samples expressed MUC1-secreted mRNA isoform in addition to the archetypal MUC1/transmembrane form. CA15.3 (soluble MUC1) levels were significantly higher in the serum of mesothelioma patients than in healthy controls but were not significantly different to levels in patients with benign asbestos-related disease. CA15-3 in effusions could differentiate malignant from benign effusions but were not specific for mesothelioma. Thus, as in other cancers, alterations in MUC1 biology occur in mesothelioma and these results suggest that specific MUC1 characteristics may be useful for mesothelioma diagnosis and should also be investigated as a potential therapeutic target.

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“…CA 19-9 increases in pleural fluids as a result of an antigenic reaction despite an invasion of serous membranes by a few tumor cells (21). While previous studies found low sensitivity but high specificity for Ca 19-9 level in malignant pleural fluids (1,9,14,15), only Kuralay et al determined both of them at high levels (19). In the present study, we found low sensitivity and high specificity of CA 19-9 level as well.…”

Section: Discussionmentioning

confidence: 93%

Diagnostic Value Of CEA, CA-19-9, CA 125 And CA 15-3 Levels In Malignant Pleural Fluids

et al. 2007

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Diagnostic value of CEA, CA 15-3, CA 19-9, CYFRA 21-1, NSE and TSA assay in pleural effusions

Cited by 107 publications

References 20 publications

Detection of cell‐free BIRC5 mRNA in effusions and its potential diagnostic value for differentiating malignant and benign effusions

Detection of cell‐free BIRC5 mRNA in effusions and its potential diagnostic value for differentiating malignant and benign effusions

Overexpression and altered glycosylation of MUC1 in malignant mesothelioma

Diagnostic Value Of CEA, CA-19-9, CA 125 And CA 15-3 Levels In Malignant Pleural Fluids

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