Diagnostic Value of Three Methods for Assessing Free Thyroxine in Pregnancy

Wilke, T J

doi:10.1177/000456328302000109

Cited by 11 publications

(4 citation statements)

References 5 publications

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“…These original findings also demonstrate the dependence of serum FT4 on clinical state and drug treatment in geriatric patients. The influence of the serum TBG level is less evident. The serum FT4 level is, in principle, independ ent of TBG; yet in non‐thyroidal illness, both positive and negative correlations have been found 38,39 . In chronic geriatric patients, a weak inverse correlation of the “two step”‐FT4 values to TBG was observed.…”

Section: Discussionmentioning

confidence: 98%

Factors Affecting the Serum Free Thyroxine Levels in Hospitalized Chronic Geriatric Patients

Szabolcs¹,

Ploenes

Beyer

et al. 1993

J American Geriatrics Society

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Section: Discussionmentioning

confidence: 98%

Factors Affecting the Serum Free Thyroxine Levels in Hospitalized Chronic Geriatric Patients

Szabolcs¹,

Ploenes

Beyer

et al. 1993

J American Geriatrics Society

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“…A low TSH value in our case also indicated a status of hyperthyroidism before the caesarean section. Some reports indicate that the free T4 index is a reliable tool for the assessment of thyroid function during pregnancy [ 14 , 15 ]. Further clinical trials are needed to identify a practical marker to determine the level of thyroid hormones during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Thyroid Storm Superimposed on Gestational Hypertension: A Case Report and Review of Literature

Chen

Liao

et al. 2022

Medicina

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A thyroid storm is an extreme manifestation of thyrotoxicosis, and is life threatening without an early diagnosis. Pregnancy or childbirth may worsen maternal hyperthyroidism or induce the development of a thyroid storm. Gestational hypertension, a disorder defined as new-onset hypertension, develops after 20 weeks of gestation and shares symptoms with a thyroid storm. The diagnosis of a thyroid storm may be challenging in patients with gestational hypertension. To highlight the significance of early thyrotoxicosis-related gastrointestinal symptoms, we report a case of a 38-year-old woman with a twin pregnancy, who was diagnosed with gestational hypertension, and then developed a thyroid storm during the peripartum period. She complained of nausea and abdominal pain, followed by tachycardia, hypertension, and a disturbance of consciousness with desaturation. After emergency caesarean section, fever, diarrhea, and high-output heart failure, with pulmonary edema, were noted during the postoperative period in the intensive care unit. The diagnosis of a thyroid storm was confirmed using the Burch–Wartofsky point scale, which was 75 points. In this patient, the uncommon gastrointestinal symptoms, as initial manifestations of thyrotoxicosis, indicated the development of a thyroid storm. The distinguished presentation of thyrotoxicosis-induced cardiomyopathy and peripartum cardiomyopathy also helped in the differential diagnosis between a thyroid storm and gestational hypertension. Aggressive treatment for thyrotoxicosis should not be delayed because of a missed diagnosis.

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“…In addition, the FT4 index (FT4I) is a reliable marker of free thyroxine status during pregnancy, correcting TT4 for alterations in TBG [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Graves’ hyperthyroidism in pregnancy: a clinical review

Nguyen

Sasso

Barton

et al. 2018

Clin Diabetes Endocrinol

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BackgroundGraves’ hyperthyroidism affects 0.2% of pregnant women. Establishing the correct diagnosis and effectively managing Graves’ hyperthyroidism in pregnancy remains a challenge for physicians.MainThe goal of this paper is to review the diagnosis and management of Graves’ hyperthyroidism in pregnancy. The paper will discuss preconception counseling, etiologies of hyperthyroidism, thyroid function testing, pregnancy-related complications, maternal management, including thyroid storm, anti-thyroid drugs and the complications for mother and fetus, fetal and neonatal thyroid function, neonatal management, and maternal post-partum management.ConclusionEstablishing the diagnosis of Graves’ hyperthyroidism early, maintaining euthyroidism, and achieving a serum total T4 in the upper limit of normal throughout pregnancy is key to reducing the risk of maternal, fetal, and newborn complications. The key to a successful pregnancy begins with preconception counseling.

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Diagnostic Value of Three Methods for Assessing Free Thyroxine in Pregnancy

Cited by 11 publications

References 5 publications

Factors Affecting the Serum Free Thyroxine Levels in Hospitalized Chronic Geriatric Patients

Factors Affecting the Serum Free Thyroxine Levels in Hospitalized Chronic Geriatric Patients

Thyroid Storm Superimposed on Gestational Hypertension: A Case Report and Review of Literature

Graves’ hyperthyroidism in pregnancy: a clinical review

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