Diagnostic Value of Two-Dimensional plus Four-Dimensional Ultrasonography in Fetal Craniocerebral Anomalies

Wang, Yingjin; Chen, Xiaoyuan; Zhong, Shujuan; Rong, Zhang; Pan, Yanyan; An, Peili; Xin-ru, Gao

doi:10.18502/ijph.v48i2.831

Cited by 3 publications

(1 citation statement)

References 20 publications

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“…Wang et al [25] used 2D and 4D to estimate the diagnostic value in fetal craniocerebral malformations. They reported that, the accuracy of 4D alone was significantly higher than 2D and combined approaches [2D plus 4D] accuracy was better than each modality alone.…”

Section: Discussionmentioning

confidence: 99%

Ultrasonographic Evaluation of Fetal Brain Midline Structures in The Second Trimester: The role of 2D versus 4D, with Post-Natal Correlation

Salam

Mustafa

Sayed

et al. 2021

International Journal of Medical Arts

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Background: Midline cerebral structures are essential for the normal morphogenesis and function of the fetal brain. However, the diagnosis of congenital anomalies of midline cerebral structures. The Aim of The Work:This study aimed to evaluate the role of 2D versus 4D ultrasound in the diagnosis of midline structures of the fetal brain at the second trimester of pregnancy.Patients and Methods: 200 pregnant women at the second trimester [18-22 weeks] were selected. They were clinically evaluated to check the female and fetal wellbeing. Then a screening of fetal brain midline strictures had been performed by two-and four-dimensional ultrasound, aiming to discover any anomalies of the fetal brain midline structure. Both scans were compared with the postnatal transcranial ultrasound. Results:The 2D ultrasound detected no abnormality in 194 out of 200 fetuses [97.0%], and 4 cases [2.0%] had mega-cisterna magna, and 2 cases [1.0%] had encephalomylocele, which were detected by the 4 D and confirmed by postnatal transcranial ultrasound. The 4 D US discovered 2 cases [1.0%] of Dandywalker malformation, which was confirmed by postnatal transcranial US. There was a complete agreement between prenatal 4D ultrasound and postnatal transcranial ultrasound. The prenatal 2D ultrasound had a sensitivity of 75.0%, specificity of 100.0%, PPV of 100.0%, NPV of 98.7% and overall accuracy of 99.0%. Otherwise, the prenatal 4D ultrasound was 100.0% sensitive and specific. Conclusion:4D ultrasound showed superiority in the diagnosis and confirmation of the fetal brain midline structure's abnormalities. Also, the prenatal 4D ultrasound was 100.0% sensitive as postnatal transcranial US.

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Section: Discussionmentioning

confidence: 99%

Ultrasonographic Evaluation of Fetal Brain Midline Structures in The Second Trimester: The role of 2D versus 4D, with Post-Natal Correlation

Salam

Mustafa

Sayed

et al. 2021

International Journal of Medical Arts

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Diagnostic Value and High-Risk Factors of Two-Dimensional Ultrasonography Combined with Four-Dimensional Ultrasonography in Prenatal Ultrasound Screening of Fetal Congenital Malformations

Liu

Gao

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. This study mainly analyzes the diagnostic value of two-dimensional ultrasonography (2D-US) combined with four-dimensional ultrasonography (4D-US) in prenatal ultrasound screening of fetal congenital malformations (CMs) and explores the high-risk factors affecting fetal malformations. Methods. The clinical and imaging data of 2247 pregnant women who underwent prenatal fetal malformation screening in the General Hospital of Ningxia Medical University between February 2020 and October 2021 were collected and analyzed, retrospectively. All pregnant women underwent 2D-US, and those with suspected fetal malformations were further inspected by 4D-US. The accuracy of ultrasound examination results relative to actual pregnancy outcomes was analyzed, taking the neonatal malformation after induced labor or actual delivery as the gold standard, and the risk factors influencing the occurrence of fetal malformations were discussed. Results. A total of 87 cases (3.87%) of fetal malformations were detected out of the 2247 parturients examined. The accuracy, sensitivity, and specificity of 2D-US diagnosis were 81.40%, 43.68%, and 82.92%, respectively, while the data were 83.67%, 51.72%, and 84.95% for 4D-US, respectively, and 93.59%, 90.80%, and 93.70%, respectively, for 2D-US +4D-US. The combined diagnosis of 2D-US +4D-US achieved statistically higher accuracy, sensitivity, and specificity than either of them alone. One-way analysis of variance and multivariate logistic regression analysis identified that the independent risk factors affecting fetal malformation were age ≥ 35 , history of adverse pregnancy and childbirth, medication during pregnancy, toxic exposure during pregnancy, and history of seropositive for TORCH-IgM. Folic acid supplementation was a protective factor. Conclusions. Prenatal US is an effective approach for screening fetal malformations. 2D-US +4D-US can effectively improve the diagnostic rate of fetal malformations. For pregnant women with high-risk factors, prevention should be given priority, and prenatal screening and prenatal diagnosis should be standardized to reduce the occurrence of fetal malformations.

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Are Fetus and Neonate the Same Individual in Terms of Behavior?

Kurjak¹,

Stanojević²

2022

Donald School Journal of Ultrasound in Obstetrics and Gynecology

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Diagnostic Value of Two-Dimensional plus Four-Dimensional Ultrasonography in Fetal Craniocerebral Anomalies

Cited by 3 publications

References 20 publications

Ultrasonographic Evaluation of Fetal Brain Midline Structures in The Second Trimester: The role of 2D versus 4D, with Post-Natal Correlation

Ultrasonographic Evaluation of Fetal Brain Midline Structures in The Second Trimester: The role of 2D versus 4D, with Post-Natal Correlation

Diagnostic Value and High-Risk Factors of Two-Dimensional Ultrasonography Combined with Four-Dimensional Ultrasonography in Prenatal Ultrasound Screening of Fetal Congenital Malformations

Are Fetus and Neonate the Same Individual in Terms of Behavior?

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