Diagnostic value of using 18F-FDG PET and PET/CT in immunocompetent patients with primary central nervous system lymphoma: A systematic review and meta-analysis

Zou, Yaru; Tong, Jinlu; Leng, Haiyan; Jiang, Jingwei; Pan, Meng; Chen, Zi

doi:10.18632/oncotarget.17456

Cited by 43 publications

(53 citation statements)

References 35 publications

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“…findings all together can mimic high-grade gliomas, metastatic tumors, tumefactive demyelinating lesions, or infectious and granulomatous diseases (54,55). Some studies suggest a role of advanced MRI and metabolic imaging such as FDG-PET in distinguishing primary central nervous system lymphoma from these entities (56). However, the histological analysis of biopsy material is still considered as the gold standard for diagnosis.…”

Section: Resultsmentioning

confidence: 99%

Primary Pituitary Lymphoma As Rare Cause Of A Pituitary Mass And Hypopituitarism In Adulthood

et al. 2020

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Section: Resultsmentioning

confidence: 99%

Primary Pituitary Lymphoma As Rare Cause Of A Pituitary Mass And Hypopituitarism In Adulthood

et al. 2020

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“…Zou et al [32] showed that PET-CT was sensitive for PCNSL. In addition, PET-CT could determine the sensitivity of PCNSL to chemotherapy faster than MRI [33].…”

Section: Discussionmentioning

confidence: 99%

Imaging features (CT, MRI, MRS, and PET/CT) of primary central nervous system lymphoma in immunocompetent patients

Cheng

Zhang

2018

Neurol Sci

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BackgroundBecause of the low incidence of primary central nervous system lymphoma (PCNSL) in non-HIV individuals and because of the lack of specific clinical manifestations and auxiliary examinations, the disease is easily missed or misdiagnosed.ObjectiveTo analyze the imaging features of PCNSL in non-HIV patients.MethodsThis was a retrospective study of patients with PCNSL treated between January 2001 and December 2011 at the Naval General Hospital (Beijing, China). All included patients were pathologically diagnosed with PCNSL. Specimens were obtained by stereotactic biopsy and diagnosed by pathological examination. Serological panel had to be negative for HIV.ResultsOut of the 118 patients, 73 (61.9%) were male and 45 (38.1%) were female. Median age was 54 (range 11–83) years. All patients had B cell lymphoma. The lesions showed slightly hyperintense shadows on computed tomography (CT) images, and mostly hyperintense T1 and iso- or hyperintense T2 signals on magnetic resonance imaging (MRI). Most lesions showed patchy enhancement after enhanced scanning, and some had the characteristic “butterfly sign” on enhanced MRI. The magnetic resonance spectroscopy of PCNSL manifested as increased Cho peak, moderately decreased NAA peak, and slightly decreased Cr peak. Positron emission computed tomography indicated high metabolism of 18F-FDG in PCNSL lesions.ConclusionMRI is important in the diagnosis of PCNSL. Understanding the imaging features of PCNSL will help improve its diagnosis in clinics.

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“…FDG uptake could be influenced by cumulative doses of corticosteroid before a PET scan, a point that should always be considered. A recent meta-analysis [ 73 ] on 18 F-FDG PET and PET/CT in PCNSL, based on 8 retrospectives studies (129 patients), revealed pooled sensitivity and specificity of 18 F-FDG-PET and PET/CT in the diagnosis of PCNSL of 0.88 and 0.86, respectively.…”

Section: Pcnsl Diagnosis: Role Of Petmentioning

confidence: 99%

Primary CNS Lymphomas: Challenges in Diagnosis and Monitoring

Chiavazza¹,

Pellerino²,

Ferrio³

et al. 2018

BioMed Research International

103

122

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Primary Central Nervous System Lymphoma (PCNSL) is a rare neoplasm that can involve brain, eye, leptomeninges, and rarely spinal cord. PCNSL lesions most typically enhance homogeneously on T1-weighted magnetic resonance imaging (MRI) and appear T2-hypointense, but high variability in MRI features is commonly encountered. Neurological symptoms and MRI findings may mimic high grade gliomas (HGGs), tumefactive demyelinating lesions (TDLs), or infectious and granulomatous diseases. Advanced MRI techniques (MR diffusion, spectroscopy, and perfusion) and metabolic imaging, such as Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) or amino acid PET (usually employing methionine), may be useful in distinguishing these different entities and monitoring the disease course. Moreover, emerging data suggest a role for cerebrospinal fluid (CSF) markers in predicting prognosis and response to treatments. In this review, we will address the challenges in PCNSL diagnosis, assessment of response to treatments, and evaluation of potential neurotoxicity related to chemotherapy and radiotherapy.

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Diagnostic value of using 18F-FDG PET and PET/CT in immunocompetent patients with primary central nervous system lymphoma: A systematic review and meta-analysis

Cited by 43 publications

References 35 publications

Primary Pituitary Lymphoma As Rare Cause Of A Pituitary Mass And Hypopituitarism In Adulthood

Primary Pituitary Lymphoma As Rare Cause Of A Pituitary Mass And Hypopituitarism In Adulthood

Imaging features (CT, MRI, MRS, and PET/CT) of primary central nervous system lymphoma in immunocompetent patients

Primary CNS Lymphomas: Challenges in Diagnosis and Monitoring

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