Diagnostic Yield and Clinical Impact of Video Capsule Endoscopy in Patients with Chronic Diarrhea: A Korean Multicenter CAPENTRY Study

Song, Hyun Joo; Moon, Jeong Seop; Jeon, Seong Ran; Kim, Jin–Oh; Kim, Jinsu; Cheung, Dae Young; Choi, Myung‐Gyu; Lim, Yun Jeong; Shim, Ki–Nam; Ye, Byong Duk; Cheon, Jae Hee; Park, Cheol Hee; Kim, Hyunsoo; Kim, Ji Hyun; Chang, Dong Kyung; Hyuk, Jae; Kim, Kyeong Ok; Jang, Byung Ik; Shin, Sungjae

doi:10.5009/gnl16231

Cited by 22 publications

(15 citation statements)

References 15 publications

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“…Current data suggest that CE should not be the first-line diagnostic test [19,20]. Song et al, demonstrated the positive diagnostic yield of CE (42.9%) in patients with chronic diarrhea, in whom the final diagnosis changed in 31.4% of patients, with Crohn’s disease being the most common finding [21]. In a systematic review of CE and unexplained chronic abdominal pain, a limited diagnostic yield of 20.9% was described.…”

Section: Discussionmentioning

confidence: 99%

Capsule Endoscopy in Refractory Diarrhea-Predominant Irritable Bowel Syndrome and Functional Abdominal Pain

et al. 2018

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Background/AimsCapsule endoscopy is a diagnostic method for evaluating the small bowel lumen and can detect undiagnosed lesions. The aim of this study was to evaluate the diagnostic yield and clinical impact of capsule endoscopy in patients with refractory diarrhea-predominant irritable bowel syndrome and functional abdominal pain. MethodsThis study involved a retrospective analysis of prospectively collected data, maintained in a database. Patients with refractory diarrhea-predominant irritable bowel syndrome and functional abdominal pain within the period of March 2012 to March 2014 were included. Capsule endoscopy was used to detect small bowel pathologies in both groups. ResultsSixty-five patients (53.8% female) fulfilled the inclusion criteria and had a mean (±standard deviation) age of 50.9±15.9 years. Clinically significant lesions were detected via capsule endoscopy in 32.5% of the patients in the abdominal pain group and 54.5% of the patients in the diarrhea group. Overall, 48% of patients had small bowel pathologies detected during the capsule endoscopy study. Inflammatory lesions and villous atrophy were the most frequent lesions identified in 16.9% and 15.3% of patients in the abdominal pain and the diarrhea groups, respectively. ConclusionsRoutine use of capsule endoscopy in patients with irritable bowel syndrome should not be recommended. However, in patients with refractory conditions, capsule endoscopy may identify abnormalities.

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Section: Discussionmentioning

confidence: 99%

Capsule Endoscopy in Refractory Diarrhea-Predominant Irritable Bowel Syndrome and Functional Abdominal Pain

et al. 2018

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“…The primary objective of this study was to evaluate the PCC system functionality in established and suspected IBD subjects. Secondary objectives included reader assessments of PCC coverage of the SB and colon, overall study reading time, capsule video quality, and safety of the system, all of which were conducted by answering a subjective questionnaire 17 .…”

Section: Methodsmentioning

confidence: 99%

Evaluation of a new pan-enteric video capsule endoscopy system in patients with suspected or established inflammatory bowel disease – feasibility study

et al. 2018

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Background and study aims Inflammatory bowel disease (IBD) affects the small bowel and colon. Endoscopic evaluation of these organs is essential. The new pan-enteric Crohn’s capsule (PCC) system is customized for complete coverage of IBD lesions in the entire bowel, allowing assessment and follow-up of disease severity and extent. The aim of this study was to evaluate the functionality of the PCC system in patients with suspected or established IBD. Patients and methods This was a prospective five-center feasibility study assessing the performance of PCC. Subjects ingested PCC after patency assurance with standard bowel preparation plus boosts. The primary endpoint was successful procedure, that is, video creation and report generation in accordance with methodology. Secondary endpoints were subjective coverage of the entire bowel, duration of reading time, video quality and occurrence of adverse events. Results Forty-one patients were included in the study with a mean age of 40.8 years ± 15.5, 46 % of whom were males. Seventy-one percent of patients had established Crohn’s disease (CD) and 53 % had active disease. Cleansing was graded good/excellent in 95 %. All 41 videos met the primary endpoint. There was no retention, 83 % reached the toilet while still recording. Thirty-one percent of patients with CD had proximal disease. Bowel coverage was graded 6.7 ± 0.6 and 6.1 ± 1.3 (1 – 7, unconfident – confident), image quality 6.1 ± 0.8 (1 – 7, poor – excellent), and reading time 3.7 ± 1.4 (1 – 7, very short to very long). Conclusions The PCC system is a minimally invasive system allowing extensive evaluation of the entire bowel in patients with IBD.

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“…Although CE is not recommended as a first-line examination for diarrhea, it facilitates making the diagnosis in 9% of patients with negative conventional endoscopy and imaging examination results [ 35 ]. The most common cause is IBD, and hematochezia and hypoalbuminemia on CE are positive predictors for it [ 36 ]. There is a lack of clinical studies on CE for patients with dyspepsia, constipation, high level CA 19-9, and abdominal distention, especially in the pediatric population.…”

Section: Discussionmentioning

confidence: 99%

Magnetic-Guided Capsule Endoscopy in the Diagnosis of Gastrointestinal Diseases in Minors

Qian

Bai

et al. 2018

Gastroenterology Research and Practice

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Objective This study aimed at investigating the clinical value of magnetic-guided capsule endoscopy (MGCE) in the diagnosis of gastrointestinal diseases in minors. Methods Eighty-four minor patients hospitalized in the pediatric department at Ruijin Hospital between June 2015 and January 2018 were enrolled for this study. Following bowel preparation, all patients underwent MGCE. The feasibility, safety, diagnostic yield, and sensitivity of MGCE were analyzed. Patients were followed up for more than 2 weeks. Results The main indications for MGCE in minors were Crohn's disease, gastrointestinal bleeding, and abdominal pain. The main causes of gastric disease were gastric inflammatory hyperplasia, exudative gastritis, and polyps. The most common small bowel diseases in minors were Crohn's disease, Henoch-Schonlein purpura, and polyps. The diagnostic yield in the stomach and small intestine was 13.1% and 28.6%, respectively, and the sensitivity was 100% and 96.0%, respectively. No adverse events occurred. Conclusion MGCE is a safe, effective, and well-tolerated procedure with good sensitivity and has a potential clinic value for the diagnosis of gastrointestinal diseases in minors.

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Diagnostic Yield and Clinical Impact of Video Capsule Endoscopy in Patients with Chronic Diarrhea: A Korean Multicenter CAPENTRY Study

Cited by 22 publications

References 15 publications

Capsule Endoscopy in Refractory Diarrhea-Predominant Irritable Bowel Syndrome and Functional Abdominal Pain

Capsule Endoscopy in Refractory Diarrhea-Predominant Irritable Bowel Syndrome and Functional Abdominal Pain

Evaluation of a new pan-enteric video capsule endoscopy system in patients with suspected or established inflammatory bowel disease – feasibility study

Magnetic-Guided Capsule Endoscopy in the Diagnosis of Gastrointestinal Diseases in Minors

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