Diallyl trisulfide (DATS) protects cardiac cells against advanced glycation end-product-induced apoptosis by enhancing FoxO3A-dependent upregulation of miRNA-210

Lin, Kuan-Ho; Ng, Shang-Chuan; Lu, Shang-Yeh; Lin, Yueh-Min; Lin, Shu-Hui; Su, Tzu-Cheng; Huang, Chih-Yang; Kuo, Wei-Wen

doi:10.1016/j.jnutbio.2024.109567

Cited by 3 publications

(2 citation statements)

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“…It phosphorylated c-Jun amino-terminal kinase (p-JNK) promoted cell proliferation and reduced apoptosis of cardiomyocytes treated with high glucose through targeting the CTRP3/JNK signaling pathway [ 76 ]. Moreover, Lin et al demonstrated that miR-210 [ 77 ] repression facilitates advanced glycation end-product (AGE)-induced cardiac mitochondrial dysfunction and apoptosis through JNK activation. On the other hand, low expression of miR-200b-3p in DCM was associated with increased cardiocyte apoptosis, and its overexpression could reduce apoptosis by targeting the CD36/PPAR-γ signaling pathway [ 78 ].…”

Section: Micrornasmentioning

confidence: 99%

“…Diallyl trisulfide (DATS) is an anti-oxidant in garlic oil, can inhibit stress-induced cardiac apoptosis and can be used as a cardioprotective agent. Lin et al found that the DATS could mediate AGE-induced cardiac cell apoptosis attenuation by promoting FoxO3a nuclear transactivation to enhance miR-210 expression and regulate JNK activation [ 77 ]. Pomegranate peel extract (PPE) exhibits a cardioprotective effect due to its anti-oxidant and anti-inflammatory properties, which could significantly ameliorate cardiac hypertrophy in diabetic rats and increase the survival rate.…”

Section: Clinical Applicationmentioning

confidence: 99%

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Roles of non-coding RNA in diabetic cardiomyopathy

Yao,

Huang,

Chen

et al. 2024

Cardiovasc Diabetol

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In recent years, the incidence of diabetes has been increasing rapidly, posing a serious threat to human health. Diabetic cardiomyopathy (DCM) is characterized by cardiomyocyte hypertrophy, myocardial fibrosis, apoptosis, ventricular remodeling, and cardiac dysfunction in individuals with diabetes, ultimately leading to heart failure and mortality. However, the underlying mechanisms contributing to DCM remain incompletely understood. With advancements in molecular biology technology, accumulating evidence has shown that numerous non-coding RNAs (ncRNAs) crucial roles in the development and progression of DCM. This review aims to summarize recent studies on the involvement of three types of ncRNAs (micro RNA, long ncRNA and circular RNA) in the pathophysiology of DCM, with the goal of providing innovative strategies for the prevention and treatment of DCM.

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Section: Micrornasmentioning

confidence: 99%

Section: Clinical Applicationmentioning

confidence: 99%

Roles of non-coding RNA in diabetic cardiomyopathy

Yao,

Huang,

Chen

et al. 2024

Cardiovasc Diabetol

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Jing‐Si Herbal Tea Suppresses H₂O₂‐Instigated Inflammation and Apoptosis by Inhibiting Bax and Mitochondrial Cytochrome C Release in HIG‐82 Synoviocytes

Kao,

Chang,

Lin

et al. 2024

Environmental Toxicology

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Inflammation is an intrinsic protective mechanism against various forms of cellular injuries in humans; however, its undesired activation results in tissue damage and cell death. The onset of chronic inflammation and oxidative stress are the key characteristics of autoimmune inflammatory diseases such as rheumatoid arthritis (RA), for which an effective treatment is yet to be developed. Therefore, in this study, we investigated the protective effects and molecular mechanisms of a novel herbal preparation, Jing‐Si herbal tea (JS), against H2O2‐induced inflammation and cellular damage in HIG‐82 synoviocytes. We found that JS did not show any significant alterations in cell viability at <188 μg/mL; however, a cytotoxic effect was observed at 188–1883 μg/mL concentrations tested. We found that expressions of inflammation associated extracellular matrix (ECM)‐degrading proteases MMP‐13, ADAMTS‐2, ‐8, and ‐17 were abnormally enhanced under H2O2‐induced pathological oxidative stress (ROS) in HIG‐82 cells. Interestingly, JS treatment not only reduced the ROS levels but also significantly repressed the protein expressions of collagen degrading proteases in a dose‐dependent manner. Treatment with JS showed enhanced cell viability against H2O2‐induced toxic ROS levels. The expressions of cell protective aggrecan, Collagen II, and Bcl‐2 were increased, whereas MMP‐13, ADAMTS‐2, Cytochrome C, and cleaved Caspase 3 were decreased by JS under inflammatory agents H2O2, MIA, LPS, and TNF‐α treatment, respectively, in HIG‐82 cells. Interestingly, the cytoprotective effect of JS treatment was attributed to a decreased mitochondrial localization of Bax and a reduction of Cytochrome C release into the cytoplasm of H2O2‐treated HIG‐82 cells. Collectively, our results suggest a novel protective mechanism of JS for RA treatment, which could be potentially applied as a complementary treatment or as an alternative therapeutic approach to mitigate inflammatory diseases.

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Safety assessment and exploration of the mechanism of toxic effects of diallyl trisulfide: Based on acute and subacute toxicity and proteomics experiments

Wu,

Tu,

et al. 2025

Journal of Ethnopharmacology

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Diallyl trisulfide (DATS) protects cardiac cells against advanced glycation end-product-induced apoptosis by enhancing FoxO3A-dependent upregulation of miRNA-210

Cited by 3 publications

References 46 publications

Roles of non-coding RNA in diabetic cardiomyopathy

Roles of non-coding RNA in diabetic cardiomyopathy

Jing‐Si Herbal Tea Suppresses H₂O₂‐Instigated Inflammation and Apoptosis by Inhibiting Bax and Mitochondrial Cytochrome C Release in HIG‐82 Synoviocytes

Safety assessment and exploration of the mechanism of toxic effects of diallyl trisulfide: Based on acute and subacute toxicity and proteomics experiments

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Diallyl trisulfide (DATS) protects cardiac cells against advanced glycation end-product-induced apoptosis by enhancing FoxO3A-dependent upregulation of miRNA-210

Cited by 3 publications

References 46 publications

Roles of non-coding RNA in diabetic cardiomyopathy

Roles of non-coding RNA in diabetic cardiomyopathy

Jing‐Si Herbal Tea Suppresses H2O2‐Instigated Inflammation and Apoptosis by Inhibiting Bax and Mitochondrial Cytochrome C Release in HIG‐82 Synoviocytes

Safety assessment and exploration of the mechanism of toxic effects of diallyl trisulfide: Based on acute and subacute toxicity and proteomics experiments

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Product

Resources

About

Jing‐Si Herbal Tea Suppresses H₂O₂‐Instigated Inflammation and Apoptosis by Inhibiting Bax and Mitochondrial Cytochrome C Release in HIG‐82 Synoviocytes