Diamond based adsorbents and their application in chromatography

Peristyy, Anton; Fedyanina, Olga N.; Paull, Brett; Nesterenko, Pavel N.

doi:10.1016/j.chroma.2014.06.044

Cited by 50 publications

(19 citation statements)

References 73 publications

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“…ii) SEM images of micro-dispersed sintered DNDs. Grid unit represents 5 nm [39]. B) SEM images of ND films deposited by hot filament CVD with CH 4 and H 2 gas.…”

Section: Figurementioning

confidence: 99%

Multifunctional nanodiamonds in regenerative medicine: Recent advances and future directions

Whitlow

Pacelli

Paul

2017

Journal of Controlled Release

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With recent advances in the field of nanomedicine, many new strategies have emerged for diagnosing and treating diseases. At the forefront of this multidisciplinary research, carbon nanomaterials have demonstrated unprecedented potential for a variety of regenerative medicine applications including novel drug delivery platforms that facilitate the localized and sustained release of therapeutics. Nanodiamonds (NDs) are a unique class of carbon nanoparticles that are gaining increasing attention for their biocompatibility, highly functional surfaces, optical properties, and robust physical properties. Their remarkable properties have established NDs as an invaluable regenerative medicine platform, with a broad range of clinically relevant applications ranging from targeted delivery systems for insoluble drugs, bioactive substrates for stem cells, and fluorescent probes for long-term tracking of cells and biomolecules in vitro and in vivo. This review introduces the synthesis techniques and the various routes of surface functionalization that allow for precise control over the properties of NDs. It also provides an in-depth overview of the current progress made towards the use of NDs in the fields of drug delivery, tissue engineering, and bioimaging. Their future outlook in regenerative medicine including the current clinical significance of NDs, as well as the challenges that must be overcome to successfully translate the reviewed technologies from research platforms to clinical therapies will also be discussed.

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“…ii) SEM images of micro-dispersed sintered DNDs. Grid unit represents 5 nm [39]. B) SEM images of ND films deposited by hot filament CVD with CH 4 and H 2 gas.…”

Section: Figurementioning

confidence: 99%

Multifunctional nanodiamonds in regenerative medicine: Recent advances and future directions

Whitlow

Pacelli

Paul

2017

Journal of Controlled Release

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“…It is considered a favourable type of polymer filler due to the improved heat dissipation during polymerisation. To-date DND has been the focus of research in areas such as biomedicine (drug delivery, biomedical implants, bio-imaging), mechanical applications (polishing and lubrication), catalytic and electrochemical applications [34], and in adsorption and separation processes [35]. DND is also attracting significant interest in the area of composite materials, including polymer-based composites [36][37][38] and carbon-carbon composites [39], and improvements in material properties have been reported as a result of DND addition [40].…”

Section: Introductionmentioning

confidence: 99%

Hierarchical porous graphitic carbon monoliths with detonation nanodiamonds: synthesis, characterisation and adsorptive properties

Duffy

Nesterenko

et al. 2015

J Mater Sci

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The addition of nano-carbons to composite materials is an area of significant research interest, when their addition results in improved properties. This work reports on the use of detonation nanodiamond (DND) in the preparation of porous carbon monoliths and an investigation of the properties of the final carbon-nanocarbon composite material. Porous carbon-nanodiamond (CND) monoliths, with macro-, meso-and micropores were prepared by carbonisation of a resorcinol-formaldehyde (RF) polymeric rod with an Fe(III) catalyst and spherical silica template. Pore characteristics and BET surface areas were determined from N 2 isotherms, with surface areas in the range of 214-461 m 2 g -1 , depending on DND content. SEM imaging further confirmed the hierarchical pore structure present, where there was a trimodal structure for monoliths containing nanodiamond following pyrolysis up to 900°C. Thermogravimetric analysis, TEM imaging, energy dispersive X-ray electron spectroscopy and Raman spectroscopy were employed to evaluate the properties of this new composite material. The adsorptions of methylene blue (MB) and neutral red (NR) dyes from water onto the composite monoliths were investigated and compared with activated carbon in order to further evaluate their physical and adsorptive properties. CND materials adsorb these two cationic dyes more effectively than activated carbon, due to a more accessible pore network, and DND content had a direct effect on adsorption capacities for the dyes. The adsorption isotherms coincided with Langmuir and Freundlich adsorption models. Maximum adsorption capacities of 599 and 284 mg g -1 were achieved for NR and MB, respectively, on the CND composites.

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“…Additionally, the surface can be readily modified to yield hydrophilic or hydrophobic properties 25 . Owing to the non-porous particle nature, columns packed with high pressure diamond stationary phases may exhibit excellent mass transfer and produce separations with maximum column efficiency of 128,200 theoretical plates per meter 26 .…”

Section: Diamond Based Stationary Phasesmentioning

confidence: 99%

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2017

IJPSR

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Impurities will be present in all drug substances and drug products, i.e. nothing is 100% pure if one looks in enough depth. The current regulatory guidance on impurities accepts this, and for drug products with a dose of less than 2 g/day identification of impurities is set at 0.1% levels and above (ICH Q3B (R2), 2006). For some impurities, this is a simple undertaking as generally available analytical techniques can address the prevailing analytical challenges; whereas, for others this may be much more challenging requiring more sophisticated analytical approaches. The present review provides an insight into current development of analytical techniques to investigate and quantify impurities in drug substances and drug products providing discussion of progress particular within the field of chromatography to ensure separation of and quantification of those related impurities. Further, a section is devoted to the identification of classical impurities, but in addition, inorganic (metal residues) and solid state impurities are also discussed. Risk control strategies for pharmaceutical impurities aligned with several of the ICH guidelines, are also discussed.

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Diamond based adsorbents and their application in chromatography

Cited by 50 publications

References 73 publications

Multifunctional nanodiamonds in regenerative medicine: Recent advances and future directions

Multifunctional nanodiamonds in regenerative medicine: Recent advances and future directions

Hierarchical porous graphitic carbon monoliths with detonation nanodiamonds: synthesis, characterisation and adsorptive properties

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