Diarrhoeagenic E. coli pathotypes in children with and without diarrhoea in an Iranian referral paediatrics centre

Abstract

Diarrhoeagenic Escherichia coli can be considered as the most important etiologic agents of diarrhoea in the Islamic Republic of Iran, particularly in children. This study determined the frequency of diarrhoeagenic E. coli isolates collected from children with acute diarrhoea (n = 50) and a control group (n = 50) at an Iranian referral paediatric centre during a 1-year period. Using multiplex PCR, diarrhoeagenic E. coli was identified in 90% of the case group and 20% of controls. Enterotoxigenic E. coli was the most frequently identified pathotype in both groups (26% in cases; 10% in controls). Shiga toxin-producing E. coli was the second most isolated pathotype (17%), followed by enteroaggregative E. coli (12%). No enteroinvasive E. coli and enteropathogenic E. coli strains were recovered. More than 80% of isolates harboured the fimH gene. This high proportion of diarrhoeagenic E. coli and diversity of E. coli types highlights the need for enhanced surveillance of gastroenteritis agents in children in this country.

Prevalence of enteroaggregative Escherichia coli among children with gastroenteritis in the northwest of Iran

“…According to our results, the total prevalence of EAEC strains was 18.2%. It is consistent with the result of Pourakbari et al 21 study in Tehran, Iran, that has reported 20.0% for the prevalence of these strains among children with diarrhea. The finding of our study is not in agreed with some studies conducted in Iran and other countries.…”

Diarrhoeagenic Escherichia coli in mother-child Pairs in Ile-Ife, South Western Nigeria

“…Multiple DEC categories were recovered from samples from 8 (6.3 %) diarrheic children between 5 and 13 months of age (Data not shown). Mixed infections are reported to involve more dehydration when compared with episodes caused by a single diarrhoeagenic E. coli pathotype [ 26 , 27 ].…”

Characterization of diarrheagenic E. coli causing a diarrheal outbreak in the south of Iran, Summer 2015

“…Diarrheagenic E. coli has been considered as one of the most common causative agents for diarrhea among sporadic cases across the country both in children and adults [13][14][15][16]. To our knowledge this is the first report of diarrheagenic E. coli as a causative agent of gastroenteritis outbreak in Iran.…”