Diarylmethanon, bromophenol and diarylmethane compounds: Discovery of potent aldose reductase, α-amylase and α-glycosidase inhibitors as new therapeutic approach in diabetes and functional hyperglycemia

Taslimi, Parham; Aslan, Hatice Esra; Demir, Yeliz; Öztaşkın, Necla; Maraş, Ahmet; Gülçın, İlhami; Beydemır, Şükrü; Göksu, Süleyman

doi:10.1016/j.ijbiomac.2018.08.004

Cited by 183 publications

(94 citation statements)

References 51 publications

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“…As a result, in spite of the high antioxidant efficiency and low cost of synthetic antioxidants the worldwide tendency nowadays is to reduce the use of synthetic antioxidants and replace them by natural antioxidants. Phenolic compounds are a group of natural compounds with phenolic structural features . All polyphenols that are recognized in plants usually are esterified with carbohydrates (glycosides) or are present as free aglycones.…”

Section: Discussionmentioning

confidence: 99%

Synthesis, characterization, antioxidant, antidiabetic, anticholinergic, and antiepileptic properties of novel N‐substituted tetrahydropyrimidines based on phenylthiourea

Maharramova

Taslimi

Sujayev

et al. 2018

J Biochem & Molecular Tox

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In the presence of trifluoroacetic acid, on the basis of three‐component condensation of phenylthiourea with its salicylaldehyde and methyl‐3‐oxobutanoate, an efficient method for the synthesis of 1‐(4‐(2‐hydroxyphenyl)‐6‐methyl‐1‐phenyl‐2‐thioxo‐1,2,3,4‐tetrahydropyrimidin‐5‐yl)ethanone (I) has been worked out. These novel N‐substituted tetrahydropyrimidines based on phenylthiourea showed good inhibitory action against acetylcholinesterase (AChE), α‐glycosidase, and human carbonic anhydrase (hCA) isoforms I and II. K i values of AChE enzyme were in the range of 0.48 to 7.46 nM. The hCA I and II were effectively inhibited by the compounds, with K i values in the range of 502.44 to 923.11 nM for hCA I and 400.32 to 801.57 nM for hCA II, respectively. The antioxidant activity of the novel N‐substituted tetrahydropyrimidines based on phenylthiourea was investigated by using different in vitro antioxidant assays; including 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH·) radical scavenging, Cu 2+ and Fe 3+ reducing activities.

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Section: Discussionmentioning

confidence: 99%

Synthesis, characterization, antioxidant, antidiabetic, anticholinergic, and antiepileptic properties of novel N‐substituted tetrahydropyrimidines based on phenylthiourea

Maharramova

Taslimi

Sujayev

et al. 2018

J Biochem & Molecular Tox

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“…After the enzyme purification, the purity degree of the enzyme was controlled according to Laemmli's method by using 3–8% batch sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS–PAGE). The electrophoresis process was carried out according to previous papers …”

Section: Methodsmentioning

confidence: 99%

“…The electrophoresis process was carried out according to previous papers. [28][29][30] In-vitro inhibition studies…”

Section: Paraoxonase Activity Assaymentioning

confidence: 99%

The behaviour of some antihypertension drugs on human serum paraoxonase-1: an important protector enzyme against atherosclerosis

Demir

2019

Journal of Pharmacy and Pharmacology

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Objectives Paraoxonase‐1 (PON1) enzyme is related to high‐density lipoprotein (HDL), which is calcium dependent. It has essential roles such as protecting LDL against oxidation and detoxification of highly toxic substances. It is a significant risk to reduce the levels of this enzyme in patients with diabetes mellitus, cardiovascular diseases, hyperthyroidism and chronic renal failure. Methods Here, it was reported that the purification of human serum PON1 using straightforward methods and determination of the interactions between some antihypertension drugs and the enzyme. Key finding It was found that these drugs exhibit potential inhibitor properties for human serum PON1 with IC50 values in the range of 131.40–369.40 μm and Ki values in the range of 56.24 ± 6.75–286.74 ± 28.28 μm. These drugs showed different inhibition mechanisms. It was determined that midodrine and nadolol were exhibited competitive inhibition, but atenolol and pindolol were exhibited non‐competitive inhibition. Conclusion Usage of these drugs would be hazardous in some cases.

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“…The α‐glycosidase (α‐Gly) enzyme breaks glycosidic chain bonds in complex carbohydrate and releases absorbable monosaccharide molecules. It is found in the epithelial mucosa cells …”

Section: Introductionmentioning

confidence: 99%

The effects of zingerone against vancomycin‐induced lung, liver, kidney and testis toxicity in rats: The behavior of some metabolic enzymes

Çağlayan

Taslimi

Demir

et al. 2019

J Biochem & Molecular Tox

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In this study, it was demonstrated the ameliorative effect of zingerone (ZO) (25 and 50 mg/kg body weight) against vancomycin (VCM) (200 mg/kg body weight) administered to rats on some metabolic enzymes’ activities in the lung, liver, kidney, and testis tissues of rats. Forty‐two rats were divided into six groups as follows: control, ZO‐25, ZO‐50, VCM, VCM + ZO‐25, and VCM + ZO‐50. α‐Glycosidase, butyrylcholinesterase, aldose reductase, acetylcholinesterase, paraoxonase‐1, and carbonic anhydrase enzyme activities were significantly (P < .05) decreased in VCM group when compared with the control group. ZO, supplied with VCM, significantly activated some of these enzyme in all tissues. The results of this study showed that ZO regulates abnormal increases and decreases in VCM‐induced metabolic enzyme activities in all tissues.

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Diarylmethanon, bromophenol and diarylmethane compounds: Discovery of potent aldose reductase, α-amylase and α-glycosidase inhibitors as new therapeutic approach in diabetes and functional hyperglycemia

Cited by 183 publications

References 51 publications

Synthesis, characterization, antioxidant, antidiabetic, anticholinergic, and antiepileptic properties of novel N‐substituted tetrahydropyrimidines based on phenylthiourea

Synthesis, characterization, antioxidant, antidiabetic, anticholinergic, and antiepileptic properties of novel N‐substituted tetrahydropyrimidines based on phenylthiourea

The behaviour of some antihypertension drugs on human serum paraoxonase-1: an important protector enzyme against atherosclerosis

The effects of zingerone against vancomycin‐induced lung, liver, kidney and testis toxicity in rats: The behavior of some metabolic enzymes

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