Diastolic Abnormalities in Normal Phenotype Hypertrophic Cardiomyopathy Gene Carriers: A Study Using Speckle Tracking Echocardiography

Abstract

This STE study confirms our previous TDI observations on increased peak late diastolic annular velocities in G+/LVH- subjects. Because of the complete overlap in early diastolic annular velocities this parameter cannot be used in the genotypes we studied to differentiate genotype (+) from genotype (-) individuals.

Abnormal Cardiac Formation in Hypertrophic Cardiomyopathy

“…Elevated EF 21,39,40 and hypercontractility 41 have been previously documented, but diastolic 42 and systolic dysfunction 43 have also been seen, although the latter may have been attributable to myocardial scar, 43 whereas our carriers were entirely free of scar. Elongation of the AMVL was also confirmed.…”

Diastolic Dysfunction of Hypertrophic Cardiomyopathy Genotype‐Positive Subjects Without Hypertrophy Is Detected by Tissue Doppler Imaging: A Systematic Review and Meta‐analysis

“…The 12 included studies for meta‐analysis covered years 2001 to 2015, regions including America, Europe and Asia, and mean age from 9.8 to 55.0. The G+/LVH− and control groups contained 302 and 349 subjects, respectively.…”

Left Ventricular and Atrial Functions in Hypertrophic Cardiomyopathy Patients with Very High LVOT Gradient: A Speckle Tracking Echocardiographic Study

“…Conventional echocardiographic parameters such as LVEF may not help to detect subclinical LV dysfunction. STE may provide better information about myocardial mechanics in HCM patients and is feasible for evaluating LV dysfunction in these patients …”

“…STE may provide better information about myocardial mechanics in HCM patients and is feasible for evaluating LV dysfunction in these patients. [12][13][14][15] In this study, we evaluated the LV and LA functions of HCM patients with conventional M-mode, 2D, tissue Doppler, and 2DSTE echocardiography. We found that left ventricular dimensions were lower, wall thickness, mass, and atrial dimensions and volumes were significantly higher in HCM patients.…”