Diastolic Dysfunction After Coronary Artery Bypass Grafting?The Effect of Glucose-Insulin-Potassium Infusion

Tsang, Michael W.; Davidoff, Ravin; Korach, Amit; Apstein, Carl S.; Hesselvik, J. F.; Nguyen, Hao G.; Shemin, Richard J.; Shapira, Oz M.

doi:10.1111/j.1540-8191.2007.00382.x

Cited by 9 publications

(4 citation statements)

References 23 publications

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“…1,2,4, 10 The hyperglycemia can have 2 main causes. 3,4 It has been demonstrated that hyperglycemia accompanies ACSs, 10 and that this is a negative predictive factor for cardiovascular risk. Hyperglycemias found in patients with low (Ͻ5 UI/mL) insulin levels should have another explanation such as pancreatic incapacity to secrete insulin due to hypoperfusion, thus compromising basal state.…”

Section: Discussionmentioning

confidence: 99%

Influence of Bedside Blood Insulin Measurement on Acute Coronary Syndrome Pathways

Panza-Nduli¹,

Coulic²,

Willems³

et al. 2011

Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine

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Section: Discussionmentioning

confidence: 99%

Influence of Bedside Blood Insulin Measurement on Acute Coronary Syndrome Pathways

Panza-Nduli¹,

Coulic²,

Willems³

et al. 2011

Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine

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“…На данный момент не выделено специфической фармакотерапии, влияющей на исход. Существуют общие подходы в интраоперационный период, например, ограничение волемической нагрузки при повышении давления наполнения или сохранение нормального ритма/ограничения тахикардии при нарушенной релаксации [28][29][30].…”

Section: ведение пациентов с дд интраоперационноunclassified

Diastolic Dysfunction of the Left Ventricle as a «time Bomb» in the Perioperative Period

Верещагин¹,

Пешкова²,

Vereshchagina³

et al. 2021

SMV

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Despite of the growing number of patients, the understanding of diastolic dysfunction (DD) and heart failure with preserved ejection fraction (HFpEF) is still not sufficient. The pathophysiological mechanisms of HFpEF are not fully investigated. The mortality rate among patients suffering from heart failure with preserved ejection fraction is the same as among patients with heart failure and reduced ejection fraction. At the moment, the diagnosis and treatment of patients with HFpEF has not been optimized despite these alarming trends. Echocardiography is the main diagnostic tool. The identification of clinically significant echocardiographic changes, even without an evident clinical picture, can contribute to a change in the patient's treatment plan or a revision of surgical tactics and anesthetic management.

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“…© 2020 Forum Multimedia Publishing, LLC Barcellos 2007;Ellenberger 2018;Foroughi 2012;Howell 2011;Koskenkari 2005;Koskenkari 2006;Lazar 2004;Licker 2019;Ranasinghe 2006;Roh 2015;Rujirojindakul 2014;Seied-Hosseini 2010;Smith 2002;Straus 2013;Tsang 2007;Visser 2005]. Figure 1 shows the details of the study selection process in the meta-analysis (Figure 1).…”

Section: E65mentioning

confidence: 99%

Effect of Perioperative Glucose-Insulin-Potassium Therapy in Patients Undergoing On-Pump Cardiac Surgery: A Meta-Analysis

Yang

Zhang

et al. 2020

HSF

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Objective: The role of glucose-insulin-potassium (GIK) infusion during cardiac surgery has held interest for so many years without a clear answer. The aim of this meta-analysis was to evaluate the effect of GIK therapy on outcomes in patients undergoing on-pump cardiac surgery. Methods: A comprehensive online review was performed in The Web of Science, Embase, Medline, PubMed, and The Cochrane Library databases from 2000 to 2019. Eligible studies included randomized controlled trials (RCTs) that compared GIK treatment with placebo or standard care during on-pump cardiac surgery. Risk ratios (RR) were used for binary outcomes and mean difference (MD) was used for continuous variables; both with their 95% confidence intervals (CI). Results: A total of 18 RCTs involving 2,131 patients met the inclusion criteria. Compared with the control group, the GIK treatment significantly reduced in-hospital mortality (RR = 0.56, 95% CI: 0.32–0.97; P = .04), postoperative myocardial infarctions (MI) (RR = 0.71, 95% CI: 0.56–0.91; P = .006), the use of inotropic support (RR = 0.53, 95% CI: 0.45–0.63; P < .00001), and length of stay in the intensive care unit (ICU) (MD = -0.33, 95% CI: -0.52–-0.14; P = .0007). Moreover, GIK treatment seemed to be associated with fewer postoperative atrial fibrillation (AF) (RR = 0.81, 95% CI: 0.64–1.03; P = .09). Conclusions: In patients undergoing on-pump cardiac surgery, GIK infusion has a beneficial role in mortality during hospital stay and demonstrates superior efficacy versus standard care for reduction in postoperative MI, AF, ICU length of stay as well as inotropic agent requirements.

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Diastolic Dysfunction After Coronary Artery Bypass Grafting?The Effect of Glucose-Insulin-Potassium Infusion

Abstract: The study was partially supported by Agilent Technologies/Philips Imaging.

Cited by 9 publications

References 23 publications

Influence of Bedside Blood Insulin Measurement on Acute Coronary Syndrome Pathways

Influence of Bedside Blood Insulin Measurement on Acute Coronary Syndrome Pathways

Diastolic Dysfunction of the Left Ventricle as a «time Bomb» in the Perioperative Period

Effect of Perioperative Glucose-Insulin-Potassium Therapy in Patients Undergoing On-Pump Cardiac Surgery: A Meta-Analysis

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