Diastolic dysfunction in aortic stenosis: Old pathophysiologic observations made a new tool

Abstract

Currently, diastolic dysfunction does not play a clear role in the management of patients with aortic stenosis. However, diastolic dysfunction, as per the 2016 ASE/EACVI guidelines, 1 in patients with moderate aortic stenosis can lead to a significantly higher mortality rate within 1, 3, and 5 years (13%, 30%, and 41%, respectively) compared to patients with normal LV diastolic function (6%, 17%, and 29%, respectively). 2 Moreover, diastolic dysfunction was independently associated with all-cause mortality and the composite endpoint of all-cause mortality and aortic valve replacement. The issue of indeterminate diastolic dysfunction, which can be as high as 25% in large populations, remains. 2 How to cite this article: Barletta G, Del Bene MR. Diastolic dysfunction in aortic stenosis: Old pathophysiologic observations made a new tool. Echocardiography.