Diastolic function in children with Kawasaki Disease

Tierney, Elif Seda Selamet; Baker, Annette L.; Fulton, David R.; Colan, Steven D.

doi:10.1016/j.ijcard.2009.11.014

Cited by 30 publications

(12 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, we observed that global S and SR decreased from basal to apical levels in both KD and normal groups. In line with our findings, Tierney et al demonstrated that there was impaired relaxation in KD patients in the early phase of the disease and also in advanced KD patients with coronary artery disease during the disease course ( 14 ). Yu et al compared patients in the acute phase of KD with normal controls ( 10 ).…”

Section: Discussionsupporting

confidence: 92%

Noninvasive Evaluation of Myocardial Systolic Dysfunction in the Early Stage of Kawasaki Disease: A Speckle-Tracking Echocardiography Study

et al. 2015

View full text Add to dashboard Cite

Background:Evaluation of myocardial function by speckle-tracking echocardiography is a new method for the early diagnosis of systolic dysfunction.Objectives:We aimed to determine myocardial speckle-tracking echocardiography indices in Kawasaki Disease (KD) patients and compare them with the same indices in control subjects.Patients and Methods:Thirty-two patients (65.5% males) with KD and 19 control subjects with normal echocardiography participated in this study. After their demographic characteristics and clinical findings were recorded, all the participants underwent transthoracic echocardiography. Strain (S), Strain Rate (SR), Time to Peak Strain (TPS), and Strain Rate (TPSR), longitudinal velocity and view point velocity images in the two, three, and four-chamber views were semi-automatically obtained via speckle-tracking echocardiography.Results:Among the patients, Twenty-four cases (75%) were younger than 4 years. Mean global S and SR was significantly reduced in the KD patients compared to controls (17.03 ± 1.28 vs. 20.22 ± 2.14% and 1.66 ± 0.16 vs. 1.97 ± 0.25 1/second, respectively), while there were no significant differences regarding mean TPS, TPSR, longitudinal velocity and view point velocity. Using repeated measure of analysis of variances, we observed that S and SR decreased from base to apical level in both groups. The change in the pattern of age adjusted mean S and SR across levels was significantly different between the groups (P < 0.001 for both parameters).Conclusions:We showed changes in S and SR assessed in KD patients versus control subjects in the acute phase of KD. However, we suggest that further studies be undertaken to compare S and SR in the acute phase and thereafter in KD patients.

show abstract

Section: Discussionsupporting

confidence: 92%

Noninvasive Evaluation of Myocardial Systolic Dysfunction in the Early Stage of Kawasaki Disease: A Speckle-Tracking Echocardiography Study

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The BNP levels were significantly associated with velocity of circumferential fiber shortening and S' at the lateral mitral annulus in the tissue Doppler study, but not significantly associated with E′ lateral, E/E′, and E/A ratios. Selamet Tierney et al ( 19 ) demonstrated decreased E' and impaired diastolic function in patients with coronary artery aneurysms. Decreased diastolic function may result in the increased BNP level.…”

Section: Discussionmentioning

confidence: 99%

Myocardial Assessment in School-Aged Children with Past Kawasaki Disease

2017

View full text Add to dashboard Cite

Coronary artery involvement remains the most important complication with Kawasaki disease (KD). Additional myocardial injury can be caused by inflammatory response and ischemic event. However, the long-term outcome of myocardial function has not been fully known in KD. The purpose of this study is to evaluate myocardial function in school-aged children who had the past history of KD. Sixty-seven children in the second grade of elementary schools, who had the past history of KD, were included. Echocardiographic measurements of each coronary artery and myocardial function were obtained as the long-term follow-up data, and compared with the baseline data at the time of initial presentation of KD. The mean age of the subjects was 8.6 ± 2.4 years, and 4.3 ± 3.4 years have passed since the diagnosis of KD. Among the echocardiographic data, interventricular septum thickness at end-diastole (IVSd), LV internal diameters at end-systole (LVIDs), maximal velocity of late diastolic filling across mitral valve (mitral A) flow, maximal velocity of early diastolic filling across mitral valve (mitral E)/A ratio, mitral inflow E wave to peak early diastolic tissue velocity (E/E') ratio showed significant differences between the baseline and follow-up measurements. Coronary Z-score of left main artery (LMA), left anterior descending (LAD), and right coronary artery (RCA) showed no significant difference. The school-aged children with the past history of KD may have diastolic dysfunction. Therefore, appropriate assessment of myocardial function would be recommended during the follow-up period in children with KD.

show abstract

“…Chronologically, myocarditis is the first documented histopathological injury in the course of the disease, followed by CA arteritis 15 . In addition to echocardiography, 16–19 there are data indicating that electrical anomalies, such as QT dispersion and atrioventricular conduction disturbances, may be present in KD patients without significant CA complications 20 …”

Section: Discussionmentioning

confidence: 99%

“…From an echocardiographic standpoint, myocardial edema and abnormal myocardial contractility have been demonstrated in the majority of patients with acute KD 16,17,21,22 . An attempt to correlate myocardial systolic and diastolic parameters with the natriuretic peptides was also reported 18,19,23 .…”

Section: Discussionmentioning

confidence: 99%