Dicalcium phosphate cements: Brushite and monetite

Tamimi, Faleh; Sheikh, Zeeshan; Barralet, Jake E.

doi:10.1016/j.actbio.2011.08.005

Cited by 369 publications

(323 citation statements)

References 123 publications

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“…Calcium hydrogen phosphate dihydrate (DCPD: CaHPO 4 Á2H 2 O), known as brushite, can be used alone or combined with other materials in the regeneration of bone and various surgical sites in animal models, because it has the ability to be resorbed under physiological conditions (Tamimi et al 2012;Hench 1998). Therefore, this study is important for bio-mineralization phenomena (Singh et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Effect of preparation conditions on the nanostructure of hydroxyapatite and brushite phases

et al. 2015

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Hydroxyapatite (HAP) and dicalcium phosphate dihydrate (brushite) nanoparticles were prepared by co-precipitation method. The obtained products were characterized by X-ray powder diffraction (XRD), Fourier transformation infra-red spectroscopy (FTIR) and thermogravimetric analysis (TGA). Scanning electron microscopy (SEM) and transmission electron microscope (TEM) were used to investigate the morphology of the powdered samples as well as their microstructure, respectively. Brushite samples were obtained in a spherical shape, while hydroxyapatite was formed in a needle and rice shape depending on the pH value.

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Section: Introductionmentioning

confidence: 99%

Effect of preparation conditions on the nanostructure of hydroxyapatite and brushite phases

et al. 2015

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“…To circumvent this problem, HA has been combined with more soluble phases such as β-tricalcium phosphate (β-TCP) [13][14][15][16]. Alternatively, more inherently soluble phases such as brushite/monetite have also demonstrated higher resorbability [17,18]. In addition, doping the crystal structure of HA with e.g.…”

Section: Introductionmentioning

confidence: 99%

In vitro degradation of calcium phosphates: Effect of multiscale porosity, textural properties and composition

et al. 2017

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Please cite this article as: Díez-Escudero, A., Espanol, M., Beats, S., Ginebra, M.P., In vitro degradation of calcium phosphates: effect of multiscale porosity, textural properties and composition, Acta Biomaterialia (2017), doi: http:// dx.doi.org/10. 1016/j.actbio.2017.07.033 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…2H 2 O) that only differs in the water of crystallization of the brushite lattice. However, despite their chemical similarity, the in vivo degradation rate has been reported to be different [7,9]. Monetite bioceramics, once implanted in the body, degrade over time encouraging new bone formation, whereas brushite tends to dissolve and reprecipitate into a less soluble CaP phase, which limits its rsif.royalsocietypublishing.org J. R. Soc.…”

Section: Discussionmentioning

confidence: 99%

“…In the last decade, many studies have focused on comparing the chemical, physical and biological properties of monetite with those of its precursor brushite in order to identify which of these materials is more suitable for bone regeneration [7,9,21]. Monetite and brushite are acidic CaP phases characterized by the same calcium to phosphorus ratio (Ca/P ¼ 1) and a chemical formula (monetite: CaHPO 4 and brushite: CaHPO 4 .…”

Section: Discussionmentioning

confidence: 99%

“…2H 2 O) and monetite (dicalcium phosphate anhydrous, DCPA: CaHPO 4 ) are of special interest as they can partake in enhancing bone formation owing to their thermodynamic metastability under physiological conditions [6]. However, brushite once in contact with biological fluids tends to dissolve and re-precipitate into a less soluble calcium phosphate (CaP) which limits its clinical application [7]. By contrast, DCPA bioceramics implanted in vivo have been found to conserve their chemical composition and degradability, allowing replacement by the newly formed bone tissue [8,9].…”

Section: Introductionmentioning

confidence: 99%

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Structural changes and biological responsiveness of an injectable and mouldable monetite bone graft generated by a facile synthetic method

Cama

Gharibi

Knowles

et al. 2014

J. R. Soc. Interface.

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Brushite (dicalcium phosphate dihydrate) and monetite (dicalcium phosphate anhydrous) are of considerable interest in bone augmentation owing to their metastable nature in physiological fluids. The anhydrous form of brushite, namely monetite, has a finer microstructure with higher surface area, strength and bioresorbability, which does not transform to the poorly resorbable hydroxyapatite, thus making it a viable alternative for use as a scaffold for engineering of bone tissue. We recently reported the formation of monetite cements by a simple processing route without the need of hydrothermal treatment by using a high concentration of sodium chloride in the reaction mix of b-tricalcium phosphate and monocalcium phosphate monohydrate. In this paper, we report the biological responsiveness of monetite formed by this method. The in vitro behaviour of monetite after interaction and ageing both in an acellular and cellular environment showed that the crystalline phase of monetite was retained over three weeks as evidenced from X-ray diffraction measurements. The crystal size and morphology also remained unaltered after ageing in different media. Human osteoblast cells seeded on monetite showed the ability of the cells to proliferate and express genes associated with osteoblast maturation and mineralization. Furthermore, the results showed that monetite could stimulate osteoblasts to undergo osteogenesis and accelerate osteoblast maturation earlier than cells cultured on hydroxyapatite scaffolds of similar porosity. Osteoblasts cultured on monetite cement also showed higher expression of osteocalcin, which is an indicator of the maturation stages of osteoblastogenesis and is associated with matrix mineralization and bone forming activity of osteoblasts. Thus, this new method of fabricating porous monetite can be safely used for generating three-dimensional bone graft constructs.

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Dicalcium phosphate cements: Brushite and monetite

Cited by 369 publications

References 123 publications

Effect of preparation conditions on the nanostructure of hydroxyapatite and brushite phases

Effect of preparation conditions on the nanostructure of hydroxyapatite and brushite phases

In vitro degradation of calcium phosphates: Effect of multiscale porosity, textural properties and composition

Structural changes and biological responsiveness of an injectable and mouldable monetite bone graft generated by a facile synthetic method

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