Dicyanostilbene-derived two-photon fluorescence probe for lead ions in live cells and living tissues

A Naphthalimide‐Based Fluorescence “Turn‐On” Probe for the Detection of Pb2+ in Aqueous Solution and Living Cells

“…[3,13] Chang et al reported the new fluorescent sensor LF1 based on fluorescein for probing Pb 2 + in living HEK cells, [3] and Huang and co-workers prepared the two-photon fluorescent probe DPb for detecting Pb 2 + in living cells. [13] However, DPb is a fluorescence "turn-off" probe for Pb 2 + . Moreover, the presence of Ag + also induced strong fluorescence quenching of DPb (ca.…”

“…Compounds NPA and M1-3 were readily synthesized in three steps from N-butyl-4bromo-1,8-naphthalimide in good yields as shown in Schemes S1-4 in the Supporting Information. The structures of all compounds were verified by 1 H NMR and 13 C NMR spectroscopies as well as high-resolution mass spectrometry (HRMS).…”

“…To our knowledge, fluorescent probes for imaging Pb 2 + in living cells are very rare. [3,13] To further demonstrate the potential application of NPA in biological systems, fluorescence imaging experiments of NPA in living cells were carried out. As shown in Figure 4, HeLa cells were first incubated with NPA for 30 min, which was followed by the addition of 2.0 equivalents of Pb 2 + and incubation for another 30 min.…”

A Synthetic Amino Acid Residue Containing A New Oligopeptide‐Based Photosensitive Fluorescent Organogel

“…[27] Stilbene derivatives can also be used as chemosensors [28] and fluorescence probes for lead ions in live cells and living tissues. [29] In addition, stilbene derivatives have been documented to be biologically important for their antimalarial [30] and antibacterial activities. [31] The neuroprotective effects of stilbene derivatives on ischemia or reperfusion brain injury have also been proved.…”

Dicyanostilbene-based Two-photon Thermo-solvatochromic Fluorescence Probes with Two-photon Triple Fluorescence

“…An ideal TP solvatochromic probe should have wide solvatochromic range, small molecule-size, and large δ and excellent photostability. Herein, we report two TP solvatochromic probes (P1 and P2) (Scheme 1) derived from 4-methyl-2,5-dicyano-4'-amino stilbene (DCS) with remarkably large δ, which has been successfully employed in the design of TPF probes for metal ions [6][7][8][9]. DCS is a push-pull chromophore with a donor-π-acceptor (D-π-A) architecture.…”