Did We Get Pasteur, Warburg, and Crabtree on a Right Note?

Vadlakonda, Lakshmipathi; Dash, Abhinandita; Pasupuleti, Mukesh; Kumar, Kotha Anil; Reddanna, Pallu

doi:10.3389/fonc.2013.00186

Cited by 10 publications

(12 citation statements)

References 55 publications

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“…[43] gen availability is known as the Pasteur effect. [44] However, in contrast to normal cells, most pyruvate in cancer cells is converted to lactate even under aerobic conditions, a phenomenon that was discovered about 100 years ago by the German physiologist Otto Warburg and is known as the Warburg effect. [45] Metabolic flux analysis of glucose and glutamine in cancer cells, performed by direct measurement in vivo, recently revealed that glycolysis serves as a major carbon-replenishing pathway for the TCA cycle in a variety of cancer types, including non-small cell lung cancer and glioblastoma ( Figure 3A).…”

Section: Glucose-derived Carbon Can Compensate For the Anaplerotic Rementioning

confidence: 99%

“…This change in the metabolic fate of pyruvate dependent on oxygen availability is known as the Pasteur effect. [ 44 ] However, in contrast to normal cells, most pyruvate in cancer cells is converted to lactate even under aerobic conditions, a phenomenon that was discovered about 100 years ago by the German physiologist Otto Warburg and is known as the Warburg effect. [ 45 ]…”

Section: Glucose‐derived Carbon Can Compensate For the Anaplerotic Rementioning

confidence: 99%

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A second Warburg‐like effect in cancer metabolism: The metabolic shift of glutamine‐derived nitrogen

Kodama

Nakayama

2020

BioEssays

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Carbon and nitrogen are essential elements for life. Glucose as a carbon source and glutamine as a nitrogen source are important nutrients for cell proliferation. About 100 years ago, it was discovered that cancer cells that have acquired unlimited proliferative capacity and undergone malignant evolution in their host manifest a cancerspecific remodeling of glucose metabolism (the Warburg effect). Only recently, however, was it shown that the metabolism of glutamine-derived nitrogen is substantially shifted from glutaminolysis to nucleotide biosynthesis during malignant progression of cancer-which might be referred to as a "second" Warburg effect. In this review, address the mechanism and relevance of this metabolic shift of glutamine-derived nitrogen in human cancer. We also examine the clinical potential of anticancer therapies that modulate the metabolic pathways of glutamine-derived nitrogen. This shift may be as important as the shift in carbon metabolism, which has long been known as the Warburg effect.

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Section: Glucose-derived Carbon Can Compensate For the Anaplerotic Rementioning

confidence: 99%

Section: Glucose‐derived Carbon Can Compensate For the Anaplerotic Rementioning

confidence: 99%

A second Warburg‐like effect in cancer metabolism: The metabolic shift of glutamine‐derived nitrogen

Kodama

Nakayama

2020

BioEssays

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“…They supply energy to the cell, producing ATP via oxidations are new targets for therapy. Perhaps the earliest proposal about the cause of cancer is the Warburg hypothesis of modified ATP production (Vadlakonda, ). Mitochondrial disfunction in breast cancer cells is involved in tumor growth, and for chemo‐prevention (Sanchez‐Alvarez et al, ).…”

Section: Bioregulation Of Amounts Of Enzymesmentioning

confidence: 99%

Bioregulation

Pardee

2015

Journal Cellular Physiology

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During the 20th century great progress was made in genetics and biochemistry, and these were combined into a molecular biological understanding of functions of macromolecules. Further great discoveries will be made about bioregulations, applicable to scientific problems such as cell development and evolution, and to illnesses including heart disease through defective control of cholesterol production, and to neurological cell-based diseases. The "War Against Cancer" is still far from won. The present generation of scientists can develop clinical applications from recent basic science discoveries.

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“…Tzenaki and Papakonstanti focus on the role of the PI3K isoform p110δ in cancer ( 4 ). The role of the PI3K/mTOR pathway in cell cycle progression and metabolism is discussed by Vadlakonda and colleagues ( 5 – 7 ). Pardo and Seckl present an overview of S6K2, the p70 ribosomal S6 kinase homolog ( 8 ).…”

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confidence: 99%