Die Bedeutung von RUNX2 in der postnatalen Entwicklung des Kondylus

Abstract

We observed that RUNX2 is involved in normal condylar growth in the mouse and probably plays a significant role in osteogenesis and angiogenesis. The RUNX2 also has a biomechanical correlation in relation to cartilage compartmentalization. At the protein level, we noted no differences in the occurrence and distribution of RUNX2 in the condyle, except for a short phase during the 4th and 6th postnatal weeks, so that one allele might suffice for largely normal growth; other biological factors may have compensatory effects. However, we did observe small changes in a few cephalometric parameters concerning the mandibles of heterozygous knockout animals. We discuss potential correlations to our findings by relating them to the most current knowledge about the RUNX2 biology.

An Immunohistochemistry Study of Sox9, Runx2, and Osterix Expression in the Mandibular Cartilages of Newborn Mouse

“…Meanwhile, four secondary cartilages, especially the condylar cartilage, were not well documented in terms of their developmental characteristics, although they function mainly as a growth cartilage similar to limb bud cartilage. At present, transcription factors are attracting increasing clinical attention because of their roles in the etiology and pathogenesis of malformations and growth disorders, degenerative diseases, and in regenerative and repair processes [21, 22]. The findings that Runx2-deficient mice lack mandibular condylar cartilage and had deformed Meckel's cartilage indicate that Runx2 is essential for the formation of the mandibular cartilages [23].…”

Crecimiento del cartílago condilar. Una revisión de la literatura

“…La mecanotrasducción es entendida como un evento molecular dinámico, donde las fuerzas mecánicas provenientes del medio, como un aparato de adelantamiento o un cambio de oclusión, se convierten en señales bioquímicas intracelulares debido a que producen una respuesta de adaptación celular en la matriz celular o hasta la misma expresión génica 71,72 . A nivel condilar la evidencia experimental disponible demuestra que el estrés mecánico constante e intermitente infiere en la capacidad de proliferación celular y la síntesis de matriz en el cartílago condilar 39,73 . Para que el estrés mecánico pueda generar un cambio en los patrones de proliferación y diferenciación celular establecidos es necesario que se produzca la transformación de una señal mecánica en un estímulo bioquímico, que se transmita a las células efectoras para que realicen su función 24,74 .…”

Prosthetic rehabilitation of a patient with cleidocranial dysplasia using dental implants—a clinical report

“…In these cases, the maxilla may be characterized by reduced anterior and posterior height, and the palate may be high, narrow, and strongly arched [12]. In the mandible, parallel rami, narrow, distally rounded coronoid processes, and changes to the condyles have been described [13]. In addition, radiological assessments of the alveolar bone show a dense and compact structure [14].…”