Die Cytogenese des Inselsystems beim Menschen

Ferner, Helmut; StoeckeniusJr., W.

doi:10.1007/bf00339894

Cited by 54 publications

(17 citation statements)

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“…4,5 The above mentioned cell types and the capsules were clearly distinguished by Masson's Trichrome staining. 6,7 Similar findings were reported by other scientists 8 also.…”

Section: Resultssupporting

confidence: 88%

Age Related Microscopic Changes on Islets of Langerhans in Human Pancreas

Sreedhar¹,

Oommen²,

Sarasammal³

2016

jemds

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BACKGROUNDThe islets of Langerhans is an important endocrine gland, which regulate the blood glucose level. The rise in the blood glucose level results in diabetes mellitus, an age old disease which affects all the systems of our body. Nowadays, an increase in the incidence of diabetes is noticed in younger age groups also. The increased intake of alcohol in our state also affects the gland. Scientific advancement like islet transplantation makes most of them correctable. So we found it is very important to assess the age related changes in the islets of Langerhans. MATERIALS AND METHODSSixty two autopsied specimens of pancreas in an age range from 6 months to 83 years were collected for analysis from the mortuary of Government Medical College, Thiruvananthapuram, Kerala. Histological examination of the glands was done in the Histology Laboratory of Department of Anatomy, Government Medical College, Thiruvananthapuram, Kerala. RESULTSA significant association between age and diameter of islets were observed in the present study. The number and size of beta cells showed a gradual increase up to 40 years, thereafter the cell number decreased considerably. In a chronic alcoholic patient, hyperplasia of islets and deposition of amyloids within the islets were observed. CONCLUSIONThe number of beta cells decreased after the age of 40 years. The beta cell destruction may be due to chemicals, diet, genetic factors and autoimmune diseases. The decrease in the number of beta cells result in type I diabetes mellitus.

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“…4,5 The above mentioned cell types and the capsules were clearly distinguished by Masson's Trichrome staining. 6,7 Similar findings were reported by other scientists 8 also.…”

Section: Resultssupporting

confidence: 88%

Age Related Microscopic Changes on Islets of Langerhans in Human Pancreas

Sreedhar¹,

Oommen²,

Sarasammal³

2016

jemds

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“…Besides A and B cells, other types of ceils (A 1, A 2, D etc.) have been described [3,4,8,13,14,18,35,36]. The identity of these unusual cell types and their functional significance has not been definitively settled.…”

Section: Introductionmentioning

confidence: 99%

La composition cytologique du pancréas endocrine foetal dans les conditions normales et pathologiques

Assche

Gepts

1971

Diabetologia

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Summary. The islets of Langerhans of the neonatal pancreas are composed of B cells and non-B cells. The non-B cells are a heterogeneous group and the composition appears to vary according to the staining method used. Silver impregnation methods sometimes impregnate a small number of B cells. No complete identity exists between argyrophilic cells (Hellerstr6m-Hellmaa~ modifications of the Davenport technique) and D cells. In babies from mothers with reduced carbohydrate tolerance the islets contain an increased proportion of B cells and Ag+ cells. Such an increase is not found in babies with erythroblastosis or alpha-thalassaemia. An active hypothalamohypophyseal system seems to be obligatory for complete maturation of the foetal islet tissue. In babies of diabetic mothers hyperplasia of the B cell appears only when a complete hypothalamo-hypophyseal system is present. La composition cytologique du panergas endocrine foetal dans les conditions normales et pathogogiquesRgsumg. Les riots de Langerhans du pancr4as n@onatM sont compos@s de cellules Bet de eellules non-B. Les cellules non-B torment un troupe h4t6rog@ne, dont la composition varie selon la technique de coloration. L'impr6-gnation argentique marque un petit hombre de eetIules B. tl n'y a pas d'6quivMenee entre les eellules argyrophiles (modifications de HellerstrSm et Hellman de la technique de Davenport) et les eellules D. I1 existe une augmentation du rapport eellules Bet eellnles argcntaffines dans les riots de Langerhans d'enfants dont la mgre prgsente un m6ta-bolisme glucidique perturb6. Ce ph4nom6ne n'a pas pu @tre mis en 4vidence chez les enfants pr6sentanfi de ]'6ry-throblastose ou de l'alpha thalass6mie. On pent admettre la ngcessit4 d'un syst~me hypothMamo-hypophysaire actif pour la maturation complgte des riots fo4taux. On eonstate chez les enfants de m@res diab@tiques une hyperplasie des cellules B lorsqu'un syst@me hypothalamo-hypophysaire complet est pr6sent.

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“…The proportion of alpha cells to ungranulated cells is higher in the slightly older pancreases ( fig. 4 and diagram D Ferner and Stoeckenius [1950] found them in their youngest foetus. They do not give reliable criteria for ageing their fretuses, but judging from the crown-heel length of 13 cm.…”

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confidence: 99%

“…These were unsatisfactory; they were difficult to use and could demonstrate only one type of differentiated cell. From the study of silver-stained sections, conclusions about the alpha and beta cells were drawn which later had to be revised [Ferner, 1938;Ferner and Stoeckenius, 1950]. With Gomori's methods, the alpha and beta cells could be reliably recognized, but the difficulty of obtaining fresh human material remained.…”

mentioning

confidence: 99%

“…This may be the reason why only two papers about the development of human pancreatic islets, using the modern stains, have so far appeared. Ferner and Stoeckenius [1950] based their conclusions on the study of only twelve fcetal pancreases; neither the date of the mother's last menstrual period (L.M.P.) nor the foetal weight is given, but to judge from the crown-heel length-an unreliable criterion-six of the fcetuses wsre in the 3rd-4th month of gestation and the remaining six in the 5th-7th month.…”

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confidence: 99%

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The Development of the Islets of Langerhans in the Human Fœtus

Robb

1961

Exp Physiol

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A hiistological study was made of the pancreatic islets of thirty-seven lhuman fcetuses, with weights ranging from 28 to 3600 g. (10 weeks' gestation to full term), using Gomori's methods of differential staining for the alpha and beta cells. Five stages of development of the islets were observed. These are described and illustrated by photomicrographs. The way in which these results supplement or differ from those of previous workers is discussed, and some experimental work concerning the influence of anterior pituitary hormones on the development of the pancreatic islets in other species is briefly reviewed.

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Die Cytogenese des Inselsystems beim Menschen

Cited by 54 publications

References 17 publications

Age Related Microscopic Changes on Islets of Langerhans in Human Pancreas

Age Related Microscopic Changes on Islets of Langerhans in Human Pancreas

La composition cytologique du pancréas endocrine foetal dans les conditions normales et pathologiques

The Development of the Islets of Langerhans in the Human Fœtus

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